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The effectiveness of SVMPs is greatly due to their functional diversity, targeting important physiological proteins or receptors in different tissues and in the coagulation system. Functional diversity is often related to the genetic diversification of the snake venom. In this review, we discuss some published evidence that posit that processing and post-translational modifications are great contributors for the generation of functional diversity and for maintaining latency or inactivation of enzymes belonging to this relevant family of venom toxins.<\/jats:p>","DOI":"10.3390\/toxins8060183","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T12:38:18Z","timestamp":1465475898000},"page":"183","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":54,"title":["Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1787-6634","authenticated-orcid":false,"given":"Ana","family":"Moura-da-Silva","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto Butantan, S\u00e3o Paulo CEP 05503-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Almeida","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto Butantan, S\u00e3o Paulo CEP 05503-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Portes-Junior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunopatologia, Instituto Butantan, S\u00e3o Paulo CEP 05503-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Nicolau","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Toxinologia, Instituto Oswaldo Cruz, Rio de Janeiro CEP 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Gomes-Neto","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Toxinologia, Instituto Oswaldo Cruz, Rio de Janeiro CEP 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6562-7571","authenticated-orcid":false,"given":"Richard","family":"Valente","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Toxinologia, Instituto Oswaldo Cruz, Rio de Janeiro CEP 21040-360, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2016,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Elhanati, Y., Sethna, Z., Marcou, Q., Callan, C.G., Mora, T., and Walczak, A.M. 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