{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:22:05Z","timestamp":1760955725847,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2017,5,20]],"date-time":"2017-05-20T00:00:00Z","timestamp":1495238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>Patulin is a water-soluble mycotoxin produced by several species of fungi. Governmental bodies have placed it under scrutiny for its potential negative health effects, and maximum residue limits are fixed in specific food matrices to protect consumers\u2019 health. Confirmatory analysis of patulin in complex food matrices can be a difficult task, and sample clean-up treatments are frequently necessary before instrumental analyses. With the aim of simplifying the clean-up step, we prepared a 256-member combinatorial polymeric library based on 16 functional monomers, four cross-linkers and four different porogenic solvents. The library was screened for the binding towards patulin in different media (acetonitrile and citrate buffer at pH 3.2), with the goal of identifying polymer formulations with good binding properties towards the target compound. As a proof of concept, a methacrylic acid-co-pentaerithrytole tetraacrylate polymer prepared in chloroform was successfully used as a solid-phase extraction material for the clean-up and extraction of patulin from apple juice. Clean chromatographic patterns and acceptable recoveries were obtained for juice spiked with patulin at concentration levels of 25 (64 \u00b1 12%), 50 (83 \u00b1 5.6%) and 100 \u03bcg L\u22121 (76 \u00b1 4.5%). The within-day and between-day reproducibility evaluated at a concentration level of 25 \u03bcg L\u22121 were 5.6 and 7.6%, respectively.<\/jats:p>","DOI":"10.3390\/toxins9050174","type":"journal-article","created":{"date-parts":[[2017,5,23]],"date-time":"2017-05-23T01:47:33Z","timestamp":1495504053000},"page":"174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Screening of a Combinatorial Library of Organic Polymers for the Solid-Phase Extraction of Patulin from Apple Juice"],"prefix":"10.3390","volume":"9","author":[{"given":"Cristina","family":"Giovannoli","sequence":"first","affiliation":[{"name":"Laboratory of Bioanalytical Chemistry, Department of Chemistry, University of Torino, Via Giuria 5, Torino 10125, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Spano","sequence":"additional","affiliation":[{"name":"Laboratory of Bioanalytical Chemistry, Department of Chemistry, University of Torino, Via Giuria 5, Torino 10125, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Di Nardo","sequence":"additional","affiliation":[{"name":"Laboratory of Bioanalytical Chemistry, Department of Chemistry, University of Torino, Via Giuria 5, Torino 10125, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2920-0140","authenticated-orcid":false,"given":"Laura","family":"Anfossi","sequence":"additional","affiliation":[{"name":"Laboratory of Bioanalytical Chemistry, Department of Chemistry, University of Torino, Via Giuria 5, Torino 10125, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1024-2532","authenticated-orcid":false,"given":"Claudio","family":"Baggiani","sequence":"additional","affiliation":[{"name":"Laboratory of Bioanalytical Chemistry, Department of Chemistry, University of Torino, Via Giuria 5, Torino 10125, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,5,20]]},"reference":[{"key":"ref_1","first-page":"202","article-title":"An antibacterial substance produced by Penicillium claviforme","volume":"23","author":"Chain","year":"1942","journal-title":"Brit. 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Union, L147, 29\u201343."}],"container-title":["Toxins"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2072-6651\/9\/5\/174\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:36:29Z","timestamp":1760207789000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2072-6651\/9\/5\/174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,20]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5]]}},"alternative-id":["toxins9050174"],"URL":"https:\/\/doi.org\/10.3390\/toxins9050174","relation":{},"ISSN":["2072-6651"],"issn-type":[{"type":"electronic","value":"2072-6651"}],"subject":[],"published":{"date-parts":[[2017,5,20]]}}}