{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:29:56Z","timestamp":1789763396569,"version":"4.0.1"},"reference-count":87,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2017,10,20]],"date-time":"2017-10-20T00:00:00Z","timestamp":1508457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Toxins"],"abstract":"<jats:p>This study investigates the long-term effects of deoxynivalenol (DON) consumption on avian growth performance, on the proliferation, apoptosis, and DNA damage of spleen cells, and on intestinal integrity. Two hundred and eight 5-day-old black-feathered Taiwan country chickens were fed diets containing 0, 2, 5, and 10 mg\/kg of DON for 16 weeks. Body weight gain of male birds in the 2 mg\/kg group was significantly lower than that in the 5 mg\/kg group. At the end of trial, feeding DON-contaminated diets of 5 mg\/kg resulted in heavier spleens. Moreover, the increase in DON induced cellular proliferation, apoptosis, and DNA damage signals in the spleen, the exception being female birds fed 10 mg\/kg of DON showing reduced proliferation. Expression of claudin-5 was increased in jejunum of female birds fed 2 and 5 mg\/kg of DON, whereas decreased expression levels were found in male birds. In conclusion, our results verified that DON may cause a disturbance to the immune system and alter the intestinal barrier in Taiwan country chickens, and may also lead to discrepancies in growth performances in a dose- and sex-dependent manner.<\/jats:p>","DOI":"10.3390\/toxins9100334","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T04:32:19Z","timestamp":1508733139000},"page":"334","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Chronic Exposure to the Fusarium Mycotoxin Deoxynivalenol: Impact on Performance, Immune Organ, and Intestinal Integrity of Slow-Growing Chickens"],"prefix":"10.3390","volume":"9","author":[{"given":"Stephanie","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Animal Science and Technology, National Taiwan University, Taipei 10673, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Hung","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology, National Taiwan University, Taipei 10673, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mei-Fong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Animal Science and Technology, National Taiwan University, Taipei 10673, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,10,20]]},"reference":[{"key":"ref_1","unstructured":"Canady, R., Coker, R., Egan, S., Krska, R., Kuiper-Goodman, T., Olsen, M., Pestka, J., Resnik, S., and Schlatter, J. 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