{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:45:18Z","timestamp":1791852318825,"version":"4.3.4"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Foundation for the Promotion of Health and Biomedical","award":["UGP-19-031"],"award-info":[{"award-number":["UGP-19-031"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Strongyloidiasis, caused by the soil-transmitted helminth Strongyloides stercoralis, is estimated to infect around 600 million people worldwide. Ivermectin is the current first-line treatment. This prospective study evaluated long-term treatment response in patients with chronic strongyloidiasis. Conducted from 2019 to 2022 at Vega Baja Hospital in Alicante, Spain, this study enrolled 28 patients diagnosed with S. stercoralis infection. Patients received ivermectin at a dosage of 200 mcg\/kg for one or two days and were followed for at least 12 months, with evaluations at 3, 6, 12, and 18 months post-treatment. Assessments included hemogram, IgE, Strongyloides serology, larvae culture and direct visualization and Strongyloides PCR in stool. Twenty-three patients completed at least 12 months of follow-up. Twenty-one patients (91.3%) achieved treatment response. Two patients (8.6%) experienced parasitological treatment failure, with detectable Strongyloides stercoralis DNA during follow-up. Ivermectin is highly effective in treating strongyloidiasis, with serology aiding in monitoring treatment efficacy. However, PCR detected an additional case of persistent infection, underscoring its complementary role.<\/jats:p>","DOI":"10.3390\/tropicalmed10040091","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T16:26:31Z","timestamp":1743611191000},"page":"91","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Strongyloidiasis Treatment Outcomes: A Prospective Study Using Serological and Molecular Methods"],"prefix":"10.3390","volume":"10","author":[{"given":"Ana","family":"Lucas Dato","sequence":"first","affiliation":[{"name":"Internal Medicine\/Infectious Diseases Department, Vega Baja Hospital-Orihuela, 03314 Alicante, Spain"},{"name":"Foundation for the Promotion of Health and Biomedical Research of the Valencia Region (FISABIO), 46020 Valencia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6329-0311","authenticated-orcid":false,"given":"Philip","family":"Wikman-Jorgensen","sequence":"additional","affiliation":[{"name":"Foundation for the Promotion of Health and Biomedical Research of the Valencia Region (FISABIO), 46020 Valencia, Spain"},{"name":"Internal Medicine\/Infectious Diseases Department, Elda General University Hospital, 03600 Alicante, Spain"},{"name":"Department of Clinical Medicine, Miguel Hernandez University of Elche, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8950-5766","authenticated-orcid":false,"given":"Jos\u00e9 Mar\u00eda","family":"Saugar Cruz","sequence":"additional","affiliation":[{"name":"Laboratory of Reference and Research in Parasitology, Centro Nacional de Microbiolog\u00eda, Instituto de Salud Carlos III, 28222 Majadahonda, Spain"},{"name":"Biomedical Research Networking Center of Infectious Diseases (CIBERINFEC), Carlos III Institute, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-7734","authenticated-orcid":false,"given":"Elisa","family":"Garc\u00eda-V\u00e1zquez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Hospital Virgen de la Arrixaca, 30120 Murcia, Spain"},{"name":"Medicine Department, University of Murcia, 30003 Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9125-7706","authenticated-orcid":false,"given":"Jara","family":"Llenas-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Internal Medicine\/Infectious Diseases Department, Vega Baja Hospital-Orihuela, 03314 Alicante, Spain"},{"name":"Foundation for the Promotion of Health and Biomedical Research of the Valencia Region (FISABIO), 46020 Valencia, Spain"},{"name":"Department of Clinical Medicine, Miguel Hernandez University of Elche, 03202 Elche, Spain"},{"name":"Biomedical Research Networking Center of Infectious Diseases (CIBERINFEC), Carlos III Institute, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e2021009","DOI":"10.4178\/epih.e2021009","article-title":"Strongyloides stercoralis and other intestinal parasites in patients receiving immunosuppressive drugs in northern Iran: A closer look at risk factors","volume":"43","author":"Mirzaei","year":"2021","journal-title":"Epidemiol. 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