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Dengue incidence has surged in recent decades, becoming a major public health concern in many regions, particularly in Brazil, which has experienced recurrent outbreaks and reported over 6.6 million probable cases in the year of 2024. While the link between the mosquito vector and dengue transmission is well understood, the effects of different DENV types and their interactions with the vector capacity of natural mosquito populations are crucial for understanding disease dynamics. Here we report findings from experiments designed to analyze and compare the infectivity and dissemination of the DENV-1 strain among five Ae. aegypti populations collected from different regions of Brazil. When exposed to DENV-infected AG129 mice for blood feeding, these populations exhibited variations in infection rates and dissemination efficiency. Eight days post-infection, all populations demonstrated high infection rates, underscoring the substantial capacity of Brazilian Ae. aegypti populations to support the locally circulating DENV-1 strain. Our results demonstrate variation in Ae. aegypti vector competence across Brazil, revealing distinct patterns of DENV transmission efficiency. These findings highlight the necessity for geographically tailored control strategies, particularly in high-risk urban areas where outbreak potential is greatest.<\/jats:p>","DOI":"10.3390\/tropicalmed10040112","type":"journal-article","created":{"date-parts":[[2025,4,20]],"date-time":"2025-04-20T20:15:06Z","timestamp":1745180106000},"page":"112","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Infectivity and Dissemination of Dengue Virus-1 in Different Aedes aegypti Populations Throughout Brazil"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8600-4077","authenticated-orcid":false,"given":"Amanda Cupertino","family":"de Freitas","sequence":"first","affiliation":[{"name":"Mosquitos Vetores: Endossimbiontes e Intera\u00e7\u00e3o Pat\u00f3geno-Vetor, Instituto Ren\u00e9 Rachou-Fiocruz, Belo Horizonte 30190-002, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5096-1254","authenticated-orcid":false,"given":"Ellen","family":"Santos","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, 6627-Pampulha, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1953-7775","authenticated-orcid":false,"given":"L\u00edvia","family":"Baldon","sequence":"additional","affiliation":[{"name":"Mosquitos Vetores: Endossimbiontes e Intera\u00e7\u00e3o Pat\u00f3geno-Vetor, Instituto Ren\u00e9 Rachou-Fiocruz, Belo Horizonte 30190-002, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1687-7806","authenticated-orcid":false,"given":"Silvana","family":"de 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Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, 6627-Pampulha, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7532-8420","authenticated-orcid":false,"given":"Jo\u00e3o Paulo Pereira","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas Gerais, 6627-Pampulha, Belo Horizonte 31270-901, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siad","family":"Amadou","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica e Imunologia, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Minas 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Soc. Bras. Med. Trop."},{"key":"ref_2","unstructured":"World Health Organization (2024). Dengue and Severe Dengue, World Health Organization. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue."},{"key":"ref_3","unstructured":"World Health Organization (2024). Dengue\u2014Global Situation, World Health Organization. Available online: https:\/\/www.who.int\/emergencies\/disease-outbreak-news\/item\/2024-DON512."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"e08347","DOI":"10.7554\/eLife.08347","article-title":"The Global Distribution of the Arbovirus Vectors Aedes aegypti and Ae. 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USA"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.mib.2008.06.004","article-title":"Structural Proteomics of Dengue Virus","volume":"11","author":"Perera","year":"2008","journal-title":"Curr. Opin. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Lambrechts, L., Scott, T.W., and Gubler, D.J. (2010). Consequences of the Expanding Global Distribution of Aedes Albopictus for Dengue Virus Transmission. PLoS Negl. Trop. 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Rev."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.virol.2017.04.009","article-title":"Dengue Virus Replicates and Accumulates in Aedes aegypti Salivary Glands","volume":"507","author":"Raquin","year":"2017","journal-title":"Virology"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"7460","DOI":"10.1073\/pnas.1101377108","article-title":"Impact of Daily Temperature Fluctuations on Dengue Virus Transmission by Aedes aegypti","volume":"108","author":"Lambrechts","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/s42003-023-05516-4","article-title":"Nutritional Stress Compromises Mosquito Fitness and Antiviral Immunity, While Enhancing Dengue Virus Infection Susceptibility","volume":"6","author":"Yan","year":"2023","journal-title":"Commun. 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