{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T09:38:56Z","timestamp":1793785136862,"version":"4.6.1"},"reference-count":48,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T00:00:00Z","timestamp":1747267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III","award":["PI21\/0148"],"award-info":[{"award-number":["PI21\/0148"]}]},{"name":"European Union","award":["PI21\/0148"],"award-info":[{"award-number":["PI21\/0148"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Altered lipid profiles have been observed in acute malaria, though mechanisms remain unclear. The impact of asymptomatic submicroscopic malaria infection (AMI) on lipids is unexploredAn observational, comparative, retrospective study was conducted of 1278 asymptomatic Sub-Saharan African migrants (ASSAMs) screened for malaria and lipid profiles during health exams (2010\u20132022). A systematic screening protocol for infectious disease was performed, including screening for Plasmodium spp. infection by polymerase chain reaction (PCR).Among 800 ASSAMs screened for malaria, 104 (13%) were PCR-positive: P. falciparum (68.72%), P. malariae (18.27%), P. ovale (9.62%), and mixed infections (3.8%). Participants with AMIs exhibited lower baseline lipid levels: total cholesterol (146 vs. 163 mg\/dL; p &lt; 0.001), HDL (43 vs. 47 mg\/dL; p &lt; 0.001), and LDL (87.5 vs. 98 mg\/dL; p &lt; 0.001), with no differences in triglycerides. After treatment, lipid levels partially equalized: total cholesterol (156 vs. 166; p = 0.01), HDL (44 vs. 47.5; p = 0.05), LDL (102 vs. 108.5; p = 0.31), with no changes in triglycerides. Patients with AMI showed higher rates of co-infections (Strongyloides 20.61% vs. 14.35%; p &lt; 0.001; filariae 7.69% vs. 1.91%; p = 0.02) and lower mean corpuscular volume (87.2 vs. 85; p &lt; 0.001). Conclusions: These findings suggest that cholesterol reductions in AMI are not solely due to acute inflammation but may reflect chronic inflammatory processes triggered by asymptomatic malaria. This supports a potential link between AMI and lipid profile changes, underscoring its role in subclinical chronic inflammation.<\/jats:p>","DOI":"10.3390\/tropicalmed10050134","type":"journal-article","created":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T06:59:16Z","timestamp":1747292356000},"page":"134","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in Lipid Profile Secondary to Asymptomatic Malaria in Migrants from Sub-Saharan Africa: A Retrospective Analysis of a 2010\u20132022 Cohort"],"prefix":"10.3390","volume":"10","author":[{"given":"Diego","family":"Gayoso-Cantero","sequence":"first","affiliation":[{"name":"National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ram\u00f3n y Cajal University Hospital, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"Health Sciences, University of Alcal\u00e1, 28871 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Corbacho-Loarte","sequence":"additional","affiliation":[{"name":"National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ram\u00f3n y Cajal University Hospital, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Crespillo-And\u00fajar","sequence":"additional","affiliation":[{"name":"National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ram\u00f3n y Cajal University Hospital, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Chamorro-Tojeiro","sequence":"additional","affiliation":[{"name":"National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ram\u00f3n y Cajal University Hospital, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Norman","sequence":"additional","affiliation":[{"name":"National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ram\u00f3n y Cajal University Hospital, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8735-4124","authenticated-orcid":false,"given":"Jose A.","family":"Perez-Molina","sequence":"additional","affiliation":[{"name":"National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ram\u00f3n y Cajal University Hospital, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3252-9748","authenticated-orcid":false,"given":"Marta","family":"Gonz\u00e1lez-Sanz","sequence":"additional","affiliation":[{"name":"National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ram\u00f3n y Cajal University Hospital, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria (IRYCIS), 28034 Madrid, Spain"},{"name":"Health Sciences, University of Alcal\u00e1, 28871 Alcal\u00e1 de Henares, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oihane","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, 28029 Madrid, Spain"},{"name":"Microbiology Department, Ram\u00f3n y Cajal University Hospital, IRYCIS, 28034 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1903-6711","authenticated-orcid":false,"given":"Jos\u00e9 Miguel","family":"Rubio","sequence":"additional","affiliation":[{"name":"National Centre for Microbiology, Instituto de Salud Carlos III, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Gull\u00f3n-Pe\u00f1a","sequence":"additional","affiliation":[{"name":"National Referral Unit for Tropical Diseases, Infectious Diseases Department, Ram\u00f3n y Cajal University Hospital, 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