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Valencia, Valencia, Spain","award":["RLA5049"],"award-info":[{"award-number":["RLA5049"]}]},{"name":"VII Convocatoria de Proyectos de Cooperaci\u00f3n al Desarrollo de la Universidad de Valencia, Valencia, Spain","award":["2017\/01"],"award-info":[{"award-number":["2017\/01"]}]},{"name":"VII Convocatoria de Proyectos de Cooperaci\u00f3n al Desarrollo de la Universidad de Valencia, Valencia, Spain","award":["2024\/12"],"award-info":[{"award-number":["2024\/12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Research is required to determine whether the coinfections by Fasciola spp. and other parasite species result from poor rural hygiene or reflect underlying epidemiological patterns and causes. Therefore, the role of fascioliasis is analyzed concerning coinfection complexity, risk of multiparasitism, parasite associations, pathogenic implications and their multifactorial causes. Helminth and protozoan coinfections are studied in 2575 previously untreated individuals from four rural hyperendemic areas (Northern Bolivian Altiplano, Peruvian Altiplano and Cajamarca valley, and the Egyptian Nile Delta). This cross-sectional study was conducted from January 2011 to December 2023. Coinfections were coprologically assessed by the merthiolate\u2013iodine\u2013formalin and formol\u2013ether concentration techniques. Infection intensity was measured as eggs\/gram of feces (epg) with the Kato\u2013Katz technique. Parasite and coinfection prevalences were stratified by age, sex and geographical location. High mixed infections, fascioliasis prevalences and very low non-coinfected Fasciola-infected subjects were associated with the following regions: Bolivian Altiplano, 96.5%, 16.8% and 3.5%; Peruvian Altiplano, 100%, 24.6% and 0%; Cajamarca valley, 98.7%, 21.4% and 1.8%; Nile Delta, 84.1%, 13.0% and 15.9%. Transmission routes and human infection sources underlie fascioliasis associations with protozoan and other helminth infections. Prevalence pattern of protozoan\u2013helminth coinfections differed between Fasciola-infected individuals and individuals not infected with Fasciola, presenting higher prevalences in individuals with fascioliasis. Multiparasitism diagnosed in Fasciola-infected subjects included coinfections by up to nine parasite species, eight protozoan species, and five helminth species. The most prevalent pathogenic protozoan was Giardia intestinalis. The most prevalent helminth species differ according to environmental conditions. Several parasites indicate fecal environmental contamination. When the fascioliasis burden increases, the total number of parasite species also increases. The fascioliasis risk increases when the total helminth species number\/host increases. Fasciola-infected subjects may present a modification in the clinical phenotypes of coinfecting parasitic diseases. Fascioliasis coinfection factors include transmission ways and immunological, environmental and social aspects. Coinfections must be considered when assessing the health impact of fascioliasis, including the analysis of the fascioliasis effects on malnutrition and physical\/intellectual child development. Fascioliasis-control schemes should, therefore, integrate control measures mainly against other helminthiases.<\/jats:p>","DOI":"10.3390\/tropicalmed10080224","type":"journal-article","created":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T11:02:09Z","timestamp":1754910129000},"page":"224","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Helminth\/Protozoan Coinfections in Chronic Fascioliasis Cases in Human Hyperendemic Areas: High Risk of Multiparasitism Linked to Transmission Aspects and Immunological, Environmental and Social Factors"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1584-8330","authenticated-orcid":false,"given":"M. Adela","family":"Valero","sequence":"first","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad de Valencia, Av. 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Manuela","family":"Morales-Suarez-Varela","sequence":"additional","affiliation":[{"name":"Departamento de Medicina Preventiva y Salud P\u00fablica, Centro Superior de Investigaci\u00f3n en Salud P\u00fablica (CSISP), Facultad de Farmacia, Universidad de Val\u00e8ncia, 46010 Valencia, Spain"},{"name":"CIBER Epidemiology and Public Health, Instituto de Salud Carlos III, C\/ Monforte de Lemos 3\u20135, Pabell\u00f3n 11, Planta 0, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7540-834X","authenticated-orcid":false,"given":"Davis J.","family":"Marquez-Guzman","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad de Valencia, Av. Vicent Andr\u00e9s Estell\u00e9s s\/n, Burjassot, 46100 Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene","family":"Angles","sequence":"additional","affiliation":[{"name":"C\u00e1tedra de Parasitolog\u00eda, Facultad de Medicina, Universidad Mayor de San Andr\u00e9s (UMSA), Av. Saavedra, Miraflores, La Paz 1010, Bolivia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2055-7554","authenticated-orcid":false,"given":"Jose R.","family":"Espinoza","sequence":"additional","affiliation":[{"name":"Department of Engineering, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martin de Porres, Lima 15102, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8846-777X","authenticated-orcid":false,"given":"Pedro","family":"Ortiz","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Veterinarias, Universidad Nacional de Cajamarca, Av. Atahualpa 1050, Cajamarca 06003, Peru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0114-8731","authenticated-orcid":false,"given":"Filippo","family":"Curtale","sequence":"additional","affiliation":[{"name":"U.O.C. Rapporti Internazionali, con le Regioni e Gestione del Ciclo di Progetto, Istituto Nazionale per la Promozione della Salute delle Popolazioni Migranti e il Contrasto delle Malattie della Povert\u00e0, 00153 Roma, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2347-7269","authenticated-orcid":false,"given":"M. Dolores","family":"Bargues","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad de Valencia, Av. Vicent Andr\u00e9s Estell\u00e9s s\/n, Burjassot, 46100 Valencia, Spain"},{"name":"CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, C\/ Monforte de Lemos 3\u20135, Pabell\u00f3n 11, Planta 0, 28029 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1685-7004","authenticated-orcid":false,"given":"Santiago","family":"Mas-Coma","sequence":"additional","affiliation":[{"name":"Departamento de Parasitolog\u00eda, Facultad de Farmacia, Universidad de Valencia, Av. 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