{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:08:04Z","timestamp":1793747284593,"version":"4.6.1"},"reference-count":34,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T00:00:00Z","timestamp":1755475200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Thailand Science Research and Innovation Fundamental","award":["TUFF 56\/2565"],"award-info":[{"award-number":["TUFF 56\/2565"]}]},{"name":"Thailand Science Research and Innovation Fundamental","award":["TUFT-FF 43\/2565"],"award-info":[{"award-number":["TUFT-FF 43\/2565"]}]},{"name":"Thammasat University Research Fund","award":["TUFF 56\/2565"],"award-info":[{"award-number":["TUFF 56\/2565"]}]},{"name":"Thammasat University Research Fund","award":["TUFT-FF 43\/2565"],"award-info":[{"award-number":["TUFT-FF 43\/2565"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Background: Dengue infection is a spreading vector borne disease with most severe infection-related fatalities occurring in adults. This study was conducted to explore prognostic indicators of dengue infection severity. Methods: This study included patients aged over 15 years who were diagnosed with dengue viral infection. Data were collected from nine hospitals across all regions of Thailand between January 2019 and December 2022. Diagnosis of dengue infection was confirmed by a positive result for the NS-1 antigen via RT\u2013PCR, IgM antibody, or IgG antibody tests. Data including gender, age, BMI, underlying disease, clinical characteristics and laboratory findings were collected. Multivariable logistic regression with backward elimination was used to identify a set of prognostic factors. Results: The prognostic indicators of severe dengue were age &lt; 55 years (OR = 6.13, p = 0.054), severe bleeding (bleeding from the gastrointestinal tract, hematemesis, melena, menorrhagia, or hematuria) (OR = 20.75, p &lt; 0.001), pleural effusion (OR = 10.23, p &lt; 0.001), and platelet \u2264 100,000 (\/\u00b5L) (OR = 3.62, p = 0.035). These predictors were able to accurately estimate the severity of dengue infection with an area under the receiver operating curve (AuROC) of 0.836. Conclusions: The proposed four prognostic factors can be applied to predict severe dengue infections. These findings may inform the development of a risk scoring system to forecast severe dengue infection, early detection, and appropriate treatment during sickness.<\/jats:p>","DOI":"10.3390\/tropicalmed10080233","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T15:34:53Z","timestamp":1755531293000},"page":"233","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic Indicators of Severe Dengue Infection in Adult Patients in Thailand"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7017-3041","authenticated-orcid":false,"given":"Patcharin","family":"Khamnuan","sequence":"first","affiliation":[{"name":"Faculty of Public Health, Thammasat University, Lampang 52190, Thailand"},{"name":"Thammasat University Research Unit in Environment, Health and Epidemiology, Lampang 52190, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7164-2412","authenticated-orcid":false,"given":"Surangrat","family":"Pongpan","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Thammasat University, Lampang 52190, Thailand"},{"name":"Thammasat University Research Unit in Environment, Health and Epidemiology, Lampang 52190, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5498-1698","authenticated-orcid":false,"given":"Pantitcha","family":"Thanatrakolsri","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Thammasat University, Lampang 52190, Thailand"},{"name":"Thammasat University Research Unit in Environment, Health and Epidemiology, Lampang 52190, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2477-4409","authenticated-orcid":false,"given":"Supa","family":"Vittaporn","sequence":"additional","affiliation":[{"name":"Faculty of Public Health, Thammasat University, Lampang 52190, Thailand"},{"name":"Thammasat University Research Unit in Environment, Health and Epidemiology, Lampang 52190, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8197-3530","authenticated-orcid":false,"given":"Punnaphat","family":"Daraswang","sequence":"additional","affiliation":[{"name":"Buriram Hospital, Muang, Buriram 31000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sirawan","family":"Samsee","sequence":"additional","affiliation":[{"name":"Sisaket Hospital, Muang, Sisaket 33000, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"ref_1","unstructured":"WHO SEARO (2025, July 26). 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