{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T16:30:37Z","timestamp":1789749037723,"version":"4.0.1"},"reference-count":30,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Salud Carlos III-Spanish Ministry of Health and Fondos Feder of the EU","award":["JR24\/00015"],"award-info":[{"award-number":["JR24\/00015"]}]},{"name":"Instituto de Salud Carlos III-Spanish Ministry of Health and Fondos Feder of the EU","award":["INT24\/00011"],"award-info":[{"award-number":["INT24\/00011"]}]},{"name":"Instituto de Salud Carlos III-Spanish Ministry of Health and Fondos Feder of the EU","award":["ICI22\/00065"],"award-info":[{"award-number":["ICI22\/00065"]}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III-Spanish Ministry of Health and Fondos Resiliencia of the EU","doi-asserted-by":"publisher","award":["JR24\/00015"],"award-info":[{"award-number":["JR24\/00015"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III-Spanish Ministry of Health and Fondos Resiliencia of the EU","doi-asserted-by":"publisher","award":["INT24\/00011"],"award-info":[{"award-number":["INT24\/00011"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III-Spanish Ministry of Health and Fondos Resiliencia of the EU","doi-asserted-by":"publisher","award":["ICI22\/00065"],"award-info":[{"award-number":["ICI22\/00065"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Dengue fever has significantly increased globally, extending into non-endemic regions. This study aims to describe the epidemiological and clinical characteristics of pediatric dengue cases diagnosed in Madrid, Spain, over ten years. We conducted a retrospective observational study across four tertiary hospitals, including all confirmed dengue cases in children under 16 between 2015 and 2024. Epidemiological data, clinical presentation, laboratory findings, and outcomes were collected, with severity assessed according to the 2009 WHO criteria. Forty-six cases were identified, with 72% diagnosed in the last three years and a peak incidence in 2024. Children visiting friends and relatives (VFR) constituted the majority of cases (56%). The most frequent clinical features were fever (100%) and gastrointestinal symptoms (78%), while laboratory findings included leukopenia (72%), thrombocytopenia (70%), and hypertransaminasemia (74%). Five cases (10%) met the criteria for severe dengue, one being fatal in a patient with pre-existing oncological disease. We identified no autochthonous cases. These results highlight the growing impact of imported pediatric dengue in non-endemic regions, the particular vulnerability of VFR travelers, and the need for clinical awareness, improved diagnostic availability and prevention strategies, especially in climate-influenced vector expansion.<\/jats:p>","DOI":"10.3390\/tropicalmed10090243","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T10:29:18Z","timestamp":1756376958000},"page":"243","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Increase of Dengue in Pediatric Travelers in Madrid: A Multicentric Retrospective Experience"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7042-8561","authenticated-orcid":false,"given":"Isabel","family":"Mellado-Sola","sequence":"first","affiliation":[{"name":"Pediatrics, Infectious Diseases and Tropical Medicine, University Hospital La Paz, 28046 Madrid, Spain"},{"name":"Pediatrics Department, University Hospital El Escorial, El Escorial, 28200 Madrid, Spain"},{"name":"La Paz Research Institute (IdiPAZ), 28046 Madrid, Spain"},{"name":"Faculty of Medicine, Autonomous University of Madrid (UAM), 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6281-2501","authenticated-orcid":false,"given":"Sonia","family":"Milkova Ivanova","sequence":"additional","affiliation":[{"name":"Pediatrics, Infectious Diseases and Tropical Medicine, University Hospital La Paz, 28046 Madrid, Spain"},{"name":"La Paz Research Institute (IdiPAZ), 28046 Madrid, Spain"},{"name":"Faculty of Medicine, Autonomous University of Madrid (UAM), 28049 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros","family":"Garc\u00eda L\u00f3pez Hortelano","sequence":"additional","affiliation":[{"name":"Pediatrics, Infectious Diseases and Tropical Medicine, University Hospital La Paz, 28046 Madrid, Spain"},{"name":"La Paz Research Institute (IdiPAZ), 28046 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Infecciosas (CIBERINFEC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2259-0393","authenticated-orcid":false,"given":"Paula","family":"Rodr\u00edguez-Molino","sequence":"additional","affiliation":[{"name":"Pediatrics, Infectious Diseases and Tropical Medicine, University Hospital La Paz, 28046 Madrid, Spain"},{"name":"La Paz Research Institute (IdiPAZ), 28046 Madrid, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Infecciosas (CIBERINFEC), 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8335-903X","authenticated-orcid":false,"given":"Cinta","family":"Moraleda","sequence":"additional","affiliation":[{"name":"Pediatrics Infectious Diseases, University Hospital 12 de Octubre, 28041 Madrid, Spain"},{"name":"Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), Fundaci\u00f3n Biom\u00e9dica del Hospital, Universitario 12 de Octubre (FIB-H12O), 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Otero Alambillaga","sequence":"additional","affiliation":[{"name":"Pediatrics Infectious Diseases, University Hospital 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rut","family":"Fern\u00e1ndez Mart\u00edn","sequence":"additional","affiliation":[{"name":"Pediatrics Infectious Diseases, University Hospital 12 de Octubre, 28041 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Jos\u00e9","family":"Collado D\u00edaz","sequence":"additional","affiliation":[{"name":"Clinical Analysis Department, University Hospital Ni\u00f1o Jes\u00fas, 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aida","family":"S\u00e1nchez Garc\u00eda","sequence":"additional","affiliation":[{"name":"Microbiology Department, University Hospital Ni\u00f1o Jes\u00fas, 28009 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-3369","authenticated-orcid":false,"given":"In\u00e9s","family":"Ojeda Vel\u00e1zquez","sequence":"additional","affiliation":[{"name":"Pediatrics and Infectious Diseases, University Hospital Gregorio Mara\u00f1\u00f3n, 28007 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4125-0423","authenticated-orcid":false,"given":"Bego\u00f1a","family":"Santiago-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Infecciosas (CIBERINFEC), 28029 Madrid, Spain"},{"name":"Pediatrics and Infectious Diseases, University 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