{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:15:43Z","timestamp":1787030143740,"version":"build-2736575974"},"reference-count":66,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Tuberculosis (TB) continues to be the world\u2019s deadliest infectious disease, with an estimated 10.8 million new cases reported in 2023, of which India alone accounted for 28% of the global burden. This study aims to evaluate the impact of tuberculosis on pulmonary function and exercise tolerance, and to examine how these impairments affect health-related quality of life (HRQoL). In a cross-sectional design, 96 bacteriologically confirmed TB patients and 96 age- and sex-matched community controls underwent spirometry, six-minute-walk test (6 MWT), and HRQoL evaluation. DR-TB was detected in 27 patients (28.1%): Isoniazid monoresistance 59.3%, rifampicin monoresistance 11.1%, and XDR-TB 29.6%. Dyspnoea (70.8%) and cough (37.5%) were the most commonly reported symptoms among TB patients. Mean values of FEV1, FVC, and FEV1\/FVC were significantly lower in TB patients compared to controls (62.8%, 65.97%, and 70.08% vs. 82.55%, 80.09%, and 78.08%, respectively; p &lt; 0.001). Recurrent or DR-TB was associated with reduced spirometric indices and 6 MWT distances (241 m vs. 358 m in drug-sensitive TB). St. George\u2019s respiratory questionnaire (SGRQ) scores indicated significantly poorer health-related quality of life (HRQoL) in patients compared to controls across all domains\u2014symptoms (23.7 vs. 10.7), activity (33.3 vs. 14.2), and impact (20.6 vs. 9.4; p &lt; 0.05). SGRQ scores were inversely correlated with lung function parameters (r = \u22120.42 to \u22120.56). These findings underscore the persistent health burden TB poses post-therapy, highlighting the need for routine post-TB functional screening and robust DR-TB control to achieve End-TB goals.<\/jats:p>","DOI":"10.3390\/tropicalmed10090247","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T16:18:15Z","timestamp":1756484295000},"page":"247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impaired Lung Function and Quality of Life Outcomes in Patients with Tuberculosis: A Cross-Sectional Study"],"prefix":"10.3390","volume":"10","author":[{"given":"Varshini","family":"Jagadeesh","sequence":"first","affiliation":[{"name":"Department of Pulmonary Medicine, Mysore Medical College and Research Institute, Mysuru 570001, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth","family":"Chikkahonnaiah","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine, Mysore Medical College and Research Institute, Mysuru 570001, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muskan","family":"Dubey","sequence":"additional","affiliation":[{"name":"Xavier University School of Medicine, Xavier University School of Veterinary Medicine, Santa Helenastraat #23, Oranjestad, Aruba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shashidhar H.","family":"Byrappa","sequence":"additional","affiliation":[{"name":"Department of Pathology, Mysore Medical College and Research Institute, Mysuru 570001, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hari Balaji","family":"Sridhar","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9689-1124","authenticated-orcid":false,"given":"Raghavendra G.","family":"Amachawadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4228-1843","authenticated-orcid":false,"given":"Ravindra P.","family":"Veeranna","sequence":"additional","affiliation":[{"name":"Xavier University School of Medicine, Xavier University School of Veterinary Medicine, Santa Helenastraat #23, Oranjestad, Aruba"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2025, June 20). Tuberculosis. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/tuberculosis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.4103\/jfmpc.jfmpc_347_18","article-title":"Effect of DOTS on Quality of Life among Tuberculosis Patients: A Follow-up Study in a Health District of Kolkata","volume":"8","author":"Banerjee","year":"2019","journal-title":"J. Fam. Med. Prim. Care"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12955-015-0250-4","article-title":"Health-Related Quality of Life and Tuberculosis: A Longitudinal Cohort Study","volume":"13","author":"Bauer","year":"2015","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_4","unstructured":"(2025, June 20). The End TB Strategy. Available online: https:\/\/www.who.int\/teams\/global-programme-on-tuberculosis-and-lung-health\/the-end-tb-strategy."},{"key":"ref_5","unstructured":"(2025, June 20). India TB Report 2022\u2014Central Tuberculosis Division, Available online: https:\/\/tbcindia.mohfw.gov.in\/2023\/06\/06\/india-tb-report-2022\/."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1016\/j.ijtb.2020.09.028","article-title":"Latent TB (LTBI) Treatment: Challenges in India with an Eye on 2025","volume":"67","author":"Rajpal","year":"2020","journal-title":"Indian J. Tuberc."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ijtb.2018.10.006","article-title":"Achieving TB Elimination in India: The Role of Latent TB Management","volume":"66","author":"Sharma","year":"2019","journal-title":"Indian J. Tuberc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"135","DOI":"10.4103\/ijmr.ijmr_382_23","article-title":"The Prevalence of Tuberculosis Infection in India: A Systematic Review and Meta-Analysis","volume":"157","author":"Chauhan","year":"2023","journal-title":"Indian J. Med. Res."},{"key":"ref_9","first-page":"49","article-title":"Guidelines for Using the QuantiFERON-TB Gold Test for Detecting Mycobacterium Tuberculosis Infection, United States","volume":"54","author":"Mazurek","year":"2005","journal-title":"Morb. Mortal. Wkly. Rep. Recomm. Rep."},{"key":"ref_10","unstructured":"World Health Organization (WHO) (2025, June 20). Drug-resistant TB. Available online: https:\/\/www.who.int\/teams\/global-programme-on-tuberculosis-and-lung-health\/tb-reports\/global-tuberculosis-report-2022\/tb-disease-burden\/2-3-drug-resistant-tb."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"a017863","DOI":"10.1101\/cshperspect.a017863","article-title":"Multidrug-Resistant Tuberculosis and Extensively Drug-Resistant Tuberculosis","volume":"5","author":"Seung","year":"2015","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1590\/s1806-37562016000000053","article-title":"Impaired Pulmonary Function after Treatment for Tuberculosis: The End of the Disease?","volume":"43","author":"Chushkin","year":"2017","journal-title":"J. Bras. Pneumol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e20180198","DOI":"10.36416\/1806-3756\/e20180198","article-title":"Spirometry Results after Treatment for Pulmonary Tuberculosis: Comparison between Patients with and without Previous Lung Disease: A Multicenter Study","volume":"46","author":"Sulmonett","year":"2020","journal-title":"J. Bras. Pneumol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"283","DOI":"10.4314\/mmj.v30i4.12","article-title":"Health-Related Quality of Life (HRQoL) Scores Vary with Treatment and May Identify Potential Defaulters during Treatment of Tuberculosis","volume":"30","author":"Olufemi","year":"2018","journal-title":"Malawi Med. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3390\/idr14040055","article-title":"Health-Related Quality of Life (HRQoL) of Patients with Tuberculosis: A Review","volume":"14","author":"Yasobant","year":"2022","journal-title":"Infect. Dis. Rep."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Duong, M., Usman, A., Ma, J., Xie, Y., Huang, J., Zaman, M., Dragoman, A., Jiatong Chen, S., Farooqi, M., and Raina, P. (2022). Associations between Lung Function and Physical and Cognitive Health in the Canadian Longitudinal Study on Aging (CLSA): A Cross-Sectional Study from a Multicenter National Cohort. PLoS Med., 19.","DOI":"10.1371\/journal.pmed.1003909"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00408-023-00658-y","article-title":"Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis","volume":"201","author":"Smirnova","year":"2023","journal-title":"Lung"},{"key":"ref_18","first-page":"198","article-title":"Pulmonary Function, Functional Capacity and Quality of Life in Adults with Cystic Fibrosis","volume":"21","author":"Lopes","year":"2015","journal-title":"Rev. Port. Pneumol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/1479972315587517","article-title":"A Longitudinal Assessment of Sleep Variables during Exacerbations of Chronic Obstructive Pulmonary Disease","volume":"12","author":"Vanaparthy","year":"2015","journal-title":"Chron. Respir. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.rmed.2008.09.022","article-title":"Determinants and Impact of Fatigue in Patients with Chronic Obstructive Pulmonary Disease","volume":"103","author":"Quint","year":"2009","journal-title":"Respir. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4187\/respcare.04597","article-title":"Physical and Functional Impairment During and After Hospitalization in Subjects with Severe COPD Exacerbation","volume":"62","author":"Valenza","year":"2017","journal-title":"Respir. Care"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1080\/15412555.2017.1342232","article-title":"Balance and Falls in Acute Exacerbation of Chronic Obstructive Pulmonary Disease: A Prospective Study","volume":"14","author":"Oliveira","year":"2017","journal-title":"COPD J. Chronic Obstr. Pulm. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.2147\/COPD.S154716","article-title":"Distribution and Characteristics of COPD Phenotypes & ndash; Results from the Polish Sub-Cohort of the POPE Study","volume":"13","author":"Kania","year":"2018","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"90","DOI":"10.3109\/15412555.2014.922063","article-title":"Do Post-Traumatic Stress Symptoms and Exacerbations in COPD Patients","volume":"12","author":"Teixeira","year":"2015","journal-title":"COPD J. Chronic Obstr. Pulm. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1023\/B:QURE.0000021317.12945.f0","article-title":"Quality of Life in Tuberculosis: Patient and Provider Perspectives","volume":"13","author":"Hansel","year":"2004","journal-title":"Qual. Life Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1207\/S15327655JCHN1604_3","article-title":"Isolation and Stigma: The Experience of Patients with Active Tuberculosis","volume":"16","author":"Kelly","year":"1999","journal-title":"J. Community Health Nurs."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100121","DOI":"10.1016\/j.jctube.2019.100121","article-title":"Quality of Life with Tuberculosis","volume":"17","author":"Aggarwal","year":"2019","journal-title":"J. Clin. Tuberc. Other Mycobact. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Cremers, A.L., de Laat, M.M., Kapata, N., Gerrets, R., Klipstein-Grobusch, K., and Grobusch, M.P. (2015). Assessing the Consequences of Stigma for Tuberculosis Patients in Urban Zambia. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119861"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ijid.2016.10.011","article-title":"Tuberculosis Stigma as a Social Determinant of Health: A Systematic Mapping Review of Research in Low Incidence Countries","volume":"56","author":"Craig","year":"2017","journal-title":"Int. J. Infect. Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0163-8343(01)00116-5","article-title":"Depression, Anxiety Comorbidity, and Disability in Tuberculosis and Chronic Obstructive Pulmonary Disease Patients: Applicability of GHQ-12","volume":"23","year":"2001","journal-title":"Gen. Hosp. Psychiatry"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s11136-012-0329-x","article-title":"Systematic Review and Meta-Analysis of the Impact of Tuberculosis on Health-Related Quality of Life","volume":"22","author":"Bauer","year":"2013","journal-title":"Qual. Life Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.socscimed.2004.08.024","article-title":"Perceptions of Tuberculosis Patients about Their Physical, Mental and Social Well-Being: A Field Report from South India","volume":"60","author":"Rajeswari","year":"2005","journal-title":"Soc. Sci. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.ijtb.2018.07.002","article-title":"A Prospective Study on Quality of Life in Patients with Pulmonary Tuberculosis at a Tertiary Care Hospital in Kashmir, Northern India","volume":"66","author":"Dar","year":"2019","journal-title":"Indian J. Tuberc."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kisaka, S.M.B., Rutebemberwa, E., Kasasa, S., Ocen, F., and Nankya-Mutyoba, J. (2016). Does Health-Related Quality of Life among Adults with Pulmonary Tuberculosis Improve across the Treatment Period? A Hospital-Based Cross Sectional Study in Mbale Region, Eastern Uganda. BMC Res. Notes, 9.","DOI":"10.1186\/s13104-016-2277-y"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/S2213-2600(24)00429-6","article-title":"Post-Tuberculosis Lung Disease: Towards Prevention, Diagnosis, and Care","volume":"13","author":"Meghji","year":"2025","journal-title":"Lancet Respir. Med."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1183\/09031936.02.00213202","article-title":"Interpretation of Quality of Life Scores from the St George\u2019s Respiratory Questionnaire","volume":"19","author":"Ferrer","year":"2002","journal-title":"Eur. Respir. J."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1081\/COPD-200050513","article-title":"St. George\u2019s Respiratory Questionnaire: MCID","volume":"2","author":"Jones","year":"2005","journal-title":"COPD J. Chronic Obstr. Pulm. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.4102\/sajp.v75i1.1319","article-title":"Post-Tuberculosis Health-Related Quality of Life, Lung Function and Exercise Capacity in a Cured Pulmonary Tuberculosis Population in the Breede Valley District, South Africa","volume":"75","author":"Daniels","year":"2019","journal-title":"S. Afr. J. Physiother."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Peddireddy, V. (2016). Quality of Life, Psychological Interventions and Treatment Outcome in Tuberculosis Patients: The Indian Scenario. Front. Psychol., 7.","DOI":"10.3389\/fpsyg.2016.01664"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1093\/annonc\/12.suppl_3.S3","article-title":"Quality of Life as a Primary End Point in Oncology","volume":"12","author":"Roila","year":"2001","journal-title":"Ann. Oncol."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Carreto-Binaghi, L.E., Sartillo-Mendoza, L.G., Mu\u00f1oz-Torrico, M., Guzm\u00e1n-Beltr\u00e1n, S., Carranza, C., Torres, M., Gonz\u00e1lez, Y., and Ju\u00e1rez, E. (2023). Serum Pro-Inflammatory Biomarkers Associated with Improvement in Quality of Life in Pulmonary Tuberculosis. Front. Immunol., 14.","DOI":"10.3389\/fimmu.2023.1241121"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1378\/chest.07-0755","article-title":"Using the St. George Respiratory Questionnaire to Ascertain Health Quality in Persons with Treated Pulmonary Tuberculosis","volume":"132","author":"Pasipanodya","year":"2007","journal-title":"Chest"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1164\/ajrccm.155.4.9105068","article-title":"Quality of Life Changes in COPD Patients Treated with Salmeterol","volume":"155","author":"Jones","year":"1997","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Kastien-Hilka, T., Rosenkranz, B., Sinanovic, E., Bennett, B., and Schwenkglenks, M. (2017). Health-Related Quality of Life in South African Patients with Pulmonary Tuberculosis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0174605"},{"key":"ref_45","first-page":"1500","article-title":"Pulmonary Tuberculosis, Impaired Lung Function, Disability and Quality of Life in a High-Burden Setting","volume":"13","author":"Maguire","year":"2009","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ijid.2019.02.039","article-title":"Pulmonary Function and Respiratory Health after Successful Treatment of Drug-Resistant Tuberculosis","volume":"82","author":"Vashakidze","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1378\/chest.06-0702","article-title":"Development and Validation of an Improved, COPD-Specific Version of the St. George Respiratory Questionnaire","volume":"132","author":"Meguro","year":"2007","journal-title":"Chest"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1183\/09031936.05.00035205","article-title":"Interpretative Strategies for Lung Function Tests","volume":"26","author":"Pellegrino","year":"2005","journal-title":"Eur. Respir. J."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"36s","DOI":"10.1183\/09031936.03.00078102","article-title":"The Assessment of Health Status among Patients with COPD","volume":"21","author":"Curtis","year":"2003","journal-title":"Eur. Respir. J."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Munro, S.A., Lewin, S.A., Smith, H.J., Engel, M.E., Fretheim, A., and Volmink, J. (2007). Patient Adherence to Tuberculosis Treatment: A Systematic Review of Qualitative Research. PLoS Med., 4.","DOI":"10.1371\/journal.pmed.0040238"},{"key":"ref_51","unstructured":"(2025, June 20). Clinical Overview of Drug-Resistant Tuberculosis Disease, Available online: https:\/\/www.cdc.gov\/tb\/hcp\/clinical-overview\/drug-resistant-tuberculosis-disease.html."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Dookie, N., Ngema, S.L., Perumal, R., Naicker, N., Padayatchi, N., and Naidoo, K. (2022). The Changing Paradigm of Drug-Resistant Tuberculosis Treatment: Successes, Pitfalls, and Future Perspectives. Clin. Microbiol. Rev., 35.","DOI":"10.1128\/cmr.00180-19"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/thx.2005.045963","article-title":"Risk Factors for Multidrug Resistant Tuberculosis in Europe: A Systematic Review","volume":"61","author":"Faustini","year":"2006","journal-title":"Thorax"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.5588\/ijtld.11.0030","article-title":"Tuberculosis in Household Contacts of Multidrug-Resistant Tuberculosis Patients","volume":"15","author":"Grandjean","year":"2011","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chung-Delgado, K., Guillen-Bravo, S., Revilla-Montag, A., and Bernabe-Ortiz, A. (2015). Mortality among MDR-TB Cases: Comparison with Drug-Susceptible Tuberculosis and Associated Factors. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0119332"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Bonilla, C.A., Crossa, A., Jave, H.O., Mitnick, C.D., Jamanca, R.B., Herrera, C., Asencios, L., Mendoza, A., Bayona, J., and Zignol, M. (2008). Management of Extensively Drug-Resistant Tuberculosis in Peru: Cure Is Possible. PLoS ONE, 3.","DOI":"10.1371\/journal.pone.0002957"},{"key":"ref_57","first-page":"780","article-title":"Risk Factors Associated with Default, Failure and Death among Tuberculosis Patients Treated in a DOTS Programme in Tiruvallur District, South India, 2000","volume":"6","author":"Santha","year":"2002","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/S0140-6736(02)08830-X","article-title":"Feasibility and Cost-Effectiveness of Standardised Second-Line Drug Treatment for Chronic Tuberculosis Patients: A National Cohort Study in Peru","volume":"359","author":"Floyd","year":"2002","journal-title":"Lancet"},{"key":"ref_59","first-page":"448","article-title":"Quality of Life of Multi Drug Resistant Tuberculosis Patients: A Study of North India","volume":"52","author":"Sharma","year":"2014","journal-title":"Acta Med. Iran."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1186\/s12955-019-1211-0","article-title":"Health-Related Quality of Life of Patients with Multidrug-Resistant Tuberculosis in Yemen: Prospective Study","volume":"17","author":"Jaber","year":"2019","journal-title":"Health Qual. Life Outcomes"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.ijtb.2021.06.002","article-title":"Health-Related Quality of Life of Multidrug-Resistant Tuberculosis Patients: A Study of Eastern Uttar Pradesh, India","volume":"69","author":"Venkatesh","year":"2022","journal-title":"Indian J. Tuberc."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Gare, K.P., Sebakeng, M., and Molefi, M. (2024). The Health-Related Quality of Life of Drug-Resistant Tuberculosis Patients Receiving Treatment in Botswana. BMC Infect. Dis., 24.","DOI":"10.1186\/s12879-024-10258-7"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S2213-2600(17)30079-6","article-title":"The Epidemiology, Pathogenesis, Transmission, Diagnosis, and Management of Multidrug-Resistant, Extensively Drug-Resistant, and Incurable Tuberculosis","volume":"5","author":"Dheda","year":"2017","journal-title":"Lancet Respir. Med."},{"key":"ref_64","first-page":"767","article-title":"Residual Lung Damage after Completion of Treatment for Multidrug-Resistant Tuberculosis","volume":"8","author":"Barker","year":"2004","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"00026-2017","DOI":"10.1183\/23120541.00026-2017","article-title":"Chronic Airflow Obstruction after Successful Treatment of Multidrug-Resistant Tuberculosis","volume":"3","author":"Byrne","year":"2017","journal-title":"ERJ Open Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tube.2012.06.003","article-title":"Predictors of Poor Outcomes among Patients Treated for Multidrug-Resistant Tuberculosis at DOTS-plus Projects","volume":"92","author":"Kurbatova","year":"2012","journal-title":"Tuberculosis"}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/10\/9\/247\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T18:35:28Z","timestamp":1760034928000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/10\/9\/247"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":66,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2025,9]]}},"alternative-id":["tropicalmed10090247"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed10090247","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]}}}