{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:40:29Z","timestamp":1789684829520,"version":"4.0.1"},"reference-count":50,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T00:00:00Z","timestamp":1760486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Genetic Research Center"},{"name":"CIG-UNAH"},{"name":"the Armed Forces Health Surveillance Division"},{"name":"Global Emerging Infections Surveillance (GEIS) Branch","award":["PROMIS ID P0091_24_N6"],"award-info":[{"award-number":["PROMIS ID P0091_24_N6"]}]},{"name":"DICIHT-UNAH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>As Honduras approaches malaria elimination, imported infections pose a growing challenge to disease surveillance and control. In this study, we analyzed 14 molecular markers\u2014six from Plasmodium falciparum and eight from P. vivax\u2014in samples from local and migrant subjects to assess their utility in differentiating local versus imported infections. All P. falciparum isolates carried the wild-type pfcrt haplotype associated with chloroquine susceptibility. However, polymorphisms in pfmdr1, pfama1, pfglurp, and pfs47 revealed distinct genotypes in migrant versus local samples, suggesting external origins. For P. vivax, three novel pvcsp VK210 haplotypes and the first detection of a VK247 variant in Honduras were identified in migrants. Additional novel haplotypes were found in pvmsp1, pvmsp3\u03b1, pvmsp3\u03b2, pvs47, and pvs48\/45. Several of these markers\u2014particularly pfmdr1, pfs47, pvs47, and pvs48\/45\u2014proved informative for inferring geographic origin. This study demonstrates the value of molecular surveillance in low-transmission settings, supporting public health efforts by identifying potentially imported cases.<\/jats:p>","DOI":"10.3390\/tropicalmed10100292","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T10:12:29Z","timestamp":1760523149000},"page":"292","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Molecular Characterization of Plasmodium Species to Strengthen Malaria Surveillance in Migrant Populations in Honduras"],"prefix":"10.3390","volume":"10","author":[{"given":"Ashley","family":"Godoy","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Microbiolog\u00eda, Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de Honduras, Tegucigalpa 11101, Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Euceda","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Microbiolog\u00eda, Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de Honduras, Tegucigalpa 11101, Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3890-0218","authenticated-orcid":false,"given":"Alejandra","family":"Pinto","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Microbiolog\u00eda, Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de Honduras, Tegucigalpa 11101, Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2159-5667","authenticated-orcid":false,"given":"Hugo O.","family":"Valdivia","sequence":"additional","affiliation":[{"name":"U.S. Naval Medical Research Unit SOUTH (NAMRU SOUTH), Department of Parasitology, Lima 07006, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesly","family":"Chaver","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional de Vigilancia de Malaria, Secretar\u00eda de Salud de Honduras, Tegucigalpa 11101, Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Ardon","sequence":"additional","affiliation":[{"name":"Laboratorio Nacional de Vigilancia de Malaria, Secretar\u00eda de Salud de Honduras, Tegucigalpa 11101, Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9756-4520","authenticated-orcid":false,"given":"Gustavo","family":"Fontecha","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Microbiolog\u00eda, Facultad de Ciencias, Universidad Nacional Aut\u00f3noma de Honduras, Tegucigalpa 11101, Honduras"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,15]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2024). 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