{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T05:16:40Z","timestamp":1764393400177,"version":"3.46.0"},"reference-count":55,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["019535"],"award-info":[{"award-number":["019535"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Antiretroviral therapy (ART) adherence behavior is heterogeneous among adolescents and young adults (AYAs) with HIV and influenced by individual and interpersonal psychosocial factors. The primary objective of this study is to characterize ART adherence phenotypes and psychosocial symptom clusters, as related to ART adherence and HIV viral load suppression. This analysis included 60 AYAs with HIV enrolled in an ART adherence support clinical trial. Self-reported ART adherence at baseline, 12-weeks, and 24-weeks was used to define four ART adherence phenotypes: consistently high adherence (YY), early-only adherence (YN), late-only adherence (NY), and consistently low adherence (NN). Symptom clusters were empirically derived from baseline psychosocial measures, including adherence self-efficacy, ART knowledge, HIV stigma, psychological distress (depression, anxiety, trauma), and social support. Linear mixed-effects models were used to examine psychosocial symptom outcomes at three timepoints (baseline, 12-weeks, and 24-weeks) and across groups with different adherence or viral load phenotypes. Using hierarchical clustering, four distinct clusters were identified, underscoring heterogeneity of psychosocial symptoms and patterns of ART and viral suppression. Findings from this analysis are among the first known characterizations of ART adherence phenotypes and psychosocial symptom clusters among AYAs with HIV. Heterogeneity in clusters underscores the need to examine other factors, such as resilience, not captured in the present study. Overall, these study findings contribute to improved understanding of the multi-level psychosocial influences of ART adherence and viral load suppression.<\/jats:p>","DOI":"10.3390\/tropicalmed10120332","type":"journal-article","created":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T16:31:54Z","timestamp":1764088314000},"page":"332","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Characterization of Antiretroviral Therapy (ART) Adherence Phenotypes and Psychosocial Symptom Clusters Among Black\/African American (AA) and Hispanic\/Latine Adolescents and Young Adults (AYAs) with HIV in the Adherence Connection for Counseling, Education, and Support (ACCESS-II) Trial"],"prefix":"10.3390","volume":"10","author":[{"given":"Ann-Margaret","family":"Navarra","sequence":"first","affiliation":[{"name":"School of Nursing, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4533-1140","authenticated-orcid":false,"given":"Taehoon","family":"Ha","sequence":"additional","affiliation":[{"name":"Biostatistical Consulting Core, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-3115","authenticated-orcid":false,"given":"Eva","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Nursing, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurade","family":"Gormley","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Connecticut, Storrs, CT 06268, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Garcia","sequence":"additional","affiliation":[{"name":"School of Nursing, University of Texas Rio Grande Valley, Rio Grande, TX 78582, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4760-7200","authenticated-orcid":false,"given":"Jason","family":"Fletcher","sequence":"additional","affiliation":[{"name":"Rory Meyers College of Nursing, New York University, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lloyd A.","family":"Goldsamt","sequence":"additional","affiliation":[{"name":"Rory Meyers College of Nursing, New York University, New York, NY 10016, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael G.","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Pediatrics, Jacobi Medical Center, Bronx, NY 10461, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-8999-0635","authenticated-orcid":false,"given":"Karin","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Applied Mathematics and Statistics, School of Engineering, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Family, Population and Preventive Medicine, School of Medicine, Stony Brook University, Stony Brook, NY 11794, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,25]]},"reference":[{"key":"ref_1","unstructured":"Centers for Disease Control and Prevention (2025, February 26). Fast Facts: HIV in the United States, Available online: https:\/\/www.cdc.gov\/hiv\/data-research\/facts-stats\/index.html."},{"key":"ref_2","unstructured":"Centers for Disease Control and Prevention (2025, July 30). Monitoring Selected National HIV Prevention and Care Objectives by Using HIV Surveillance Data United States and 6 Territories and Freely Associated States, 2022, HIV Surveillance Supplemental Report, Available online: http:\/\/stacks.cdc.gov\/view\/cdc\/156511."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/QAI.0000000000002142","article-title":"Antiretroviral adherence level necessary for HIV viral suppression using real-world data","volume":"82","author":"Byrd","year":"2019","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_4","unstructured":"Centers for Disease Control and Prevention (2025, February 26). Behavioral and Clinical Characteristics of Persons with Diagnosed HIV Infection\u2014Medical Monitoring Project, United States, 2019 Cycle (June 2019\u2013May 2020), HIV Surveillance Supplemental Report 28, Available online: https:\/\/stacks.cdc.gov\/view\/cdc\/110355."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.15585\/mmwr.mm6848e1","article-title":"Vital Signs: Status of Human Immunodeficiency Virus Testing, Viral Suppression, and HIV Preexposure Prophylaxis-United States, 2013\u20132018","volume":"68","author":"Harris","year":"2019","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.2105\/AJPH.2019.305108","article-title":"Pediatric HIV\/AIDS Cohort Study. Disparities in HIV viral suppression among adolescents and young adults by perinatal infection","volume":"109","author":"Patel","year":"2019","journal-title":"Am. J. Public Health"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1002\/oby.21924","article-title":"Behavioral and psychological phenotyping of physical activity and sedentary behavior: Implications for weight management","volume":"25","author":"Bryan","year":"2017","journal-title":"Obes. Res."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/hiv.12690","article-title":"High-risk behaviours, and their associations with mental health, adherence to antiretroviral therapy and HIV parameters, in HIV-positive men who have sex with men","volume":"20","author":"Pool","year":"2019","journal-title":"HIV Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s10461-017-2001-5","article-title":"Positive psychological factors are linked to successful cognitive aging among older persons living with HIV\/AIDS","volume":"22","author":"Moore","year":"2018","journal-title":"AIDS Behav."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"djw253","DOI":"10.1093\/jnci\/djw253","article-title":"Advancing symptom science through symptom cluster research: Expert panel proceedings and recommendations","volume":"109","author":"Miaskowski","year":"2017","journal-title":"JNCI"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e531","DOI":"10.1016\/S2352-3018(19)30148-1","article-title":"Combined estimation of disease progression and retention on antiretroviral therapy among treated individuals with HIV in the USA: A modelling study","volume":"6","author":"Wang","year":"2019","journal-title":"Lancet HIV"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/NNR.0000000000000422","article-title":"Adherence self-management and the influence of contextual factors among emerging adults with human immunodeficiency virus","volume":"69","author":"Navarra","year":"2020","journal-title":"Nurs. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1700391","DOI":"10.1183\/13993003.00391-2017","article-title":"What is precision medicine?","volume":"50","author":"Fuchs","year":"2017","journal-title":"Eur. Respir. J."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"De Francesco, D., Underwood, J., Post, F.A., Vera, J.H., Williams, I., Boffito, M., Sachikonye, M., Anderson, J., Mallon, P.W., and Winston, A. (2016). Defining cognitive impairment in people-living-with-HIV: The POPPY study. BMC Infect. Dis., 16.","DOI":"10.1186\/s12879-016-1970-8"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1080\/15381501.2013.859111","article-title":"Characterizing HIV medication adherence for virologic success among individuals living with HIV\/AIDS: Experience with the CNS HIV Antiretroviral Therapy Effects Research (CHARTER) cohort","volume":"13","author":"Biswas","year":"2014","journal-title":"J. HIV AIDS Soc. Serv."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"fcae224","DOI":"10.1093\/braincomms\/fcae224","article-title":"Biopsychosocial phenotypes in people with HIV in the CHARTER cohort","volume":"6","author":"Tang","year":"2024","journal-title":"Brain Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1007\/s10461-025-04623-z","article-title":"Predicting Trajectories of Everyday Functioning in Adults Aging with HIV Using Latent Growth Mixture Modeling","volume":"29","author":"Ham","year":"2025","journal-title":"AIDS Behav."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Dom\u00ednguez-Rodr\u00edguez, S., Tagarro, A., Foster, C., Palma, P., Cotugno, N., Zicari, S., Ruggiero, A., de Rossi, A., Dalzini, A., and Pahwa, S. (2022). Clinical, virological and immunological subphenotypes in a cohort of early treated HIV-infected children. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.875692"},{"key":"ref_19","unstructured":"Bronfenbrenner, U. (2005). Making Human Beings Human: Bioecological Perspectives on Human Development, Sage."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100263","DOI":"10.1016\/j.pecinn.2024.100263","article-title":"Developing and testing a web-based platform for antiretroviral therapy (ART) adherence support among adolescents and young adults (AYA) living with HIV","volume":"4","author":"Navarra","year":"2024","journal-title":"PEC Innov."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e12543","DOI":"10.2196\/12543","article-title":"Adherence connection for counseling, education, and support: Research protocol for a proof-of-concept study","volume":"8","author":"Navarra","year":"2019","journal-title":"JMIR Res. Protoc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"S250","DOI":"10.1097\/QAI.0000000000000236","article-title":"Health behavior change models for HIV prevention and AIDS care: Practical recommendations for a multi-level approach","volume":"66","author":"Kaufman","year":"2014","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1097\/01.mlr.0000258615.42478.55","article-title":"The Patient-Reported Outcomes Measurement Information System (PROMIS): Progress of an NIH Roadmap cooperative group during its first two years","volume":"45","author":"Cella","year":"2007","journal-title":"Med. Care"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.jadohealth.2010.03.013","article-title":"Medication adherence in adolescents with behaviorally-acquired HIV: Evidence for using a multimethod assessment protocol","volume":"47","author":"Garvie","year":"2010","journal-title":"J. Adolesc. Health"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1097\/QAI.0b013e318158a44f","article-title":"Optimizing measurement of self-reported adherence with the ACTG Adherence Questionnaire: A cross-protocol analysis","volume":"46","author":"Reynolds","year":"2007","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1007\/s10461-019-02448-1","article-title":"Measuring antiretroviral adherence among young people living with HIV: Observations from a real-time monitoring device versus self-report","volume":"23","author":"Craker","year":"2019","journal-title":"AIDS Behav."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1080\/09540120701352241","article-title":"Development and psychometric validation of the HIV Treatment Knowledge Scale","volume":"19","author":"Balfour","year":"2007","journal-title":"AIDS Care"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1111\/j.1365-2648.2010.05400.x","article-title":"The HIV Medication Taking Self-efficacy Scale: Psychometric evaluation","volume":"66","author":"Erlen","year":"2010","journal-title":"J. Adv. Nurs."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/nur.10011","article-title":"Measuring stigma in people with HIV: Psychometric assessment of the HIV stigma scale","volume":"24","author":"Berger","year":"2001","journal-title":"Res. Nurs. Health"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"e11207","DOI":"10.2196\/11207","article-title":"Adolescent medicine trials network for HIV\/AIDS interventions data harmonization: Rationale and development of guidelines","volume":"7","author":"McCumber","year":"2018","journal-title":"JMIR Res. Protoc."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1037\/hea0000055","article-title":"New English and Spanish social health measures will facilitate evaluating health determinants","volume":"33","author":"Hahn","year":"2014","journal-title":"Health Psychol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: The GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"Validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J. Gen. Intern. Med."},{"key":"ref_34","first-page":"9","article-title":"The Primary Care PTSD Screen (PC-PTSD): Development and operating characteristics. International Journal of Psychiatry in Clinical Practice","volume":"9","author":"Prins","year":"2004","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1080\/1067828X.2015.1049395","article-title":"ASSIST-Y v1. 0: First-stage Development of the WHO Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) and Linked Brief Intervention for Young People","volume":"25","author":"Humeniuk","year":"2016","journal-title":"J. Child Adolesc. Subst. Abuse"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Zhang, W., Shi, J., Wang, Y., Li, E., Yan, D., Zhang, Z., Zhu, M., Yu, J., and Wang, Y. (2024). Risk factors and clinical prediction models for low-level viremia in people living with HIV receiving antiretroviral therapy: An 11-year retrospective study. Front. Microbiol., 15.","DOI":"10.3389\/fmicb.2024.1451201"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1093\/cid\/ciz129","article-title":"Persistent low-level viremia while on antiretroviral therapy is an independent risk factor for virologic failure","volume":"69","author":"Joya","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Elvstam, O., Medstrand, P., Yilmaz, A., Isberg, P.-E., Gisslen, M., and Bj\u00f6rkman, P. (2017). Virological failure and all-cause mortality in HIV-positive adults with low-level viremia during antiretroviral treatment. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0180761"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/cid\/ciad219","article-title":"Plasma human immunodeficiency virus 1 RNA and CD4+ T-cell counts are determinants of virological nonsuppression outcomes with initial integrase inhibitor-based regimens: A prospective RESPOND cohort study","volume":"77","author":"Mocroft","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1097\/QAD.0000000000003990","article-title":"Consequences of low-level viremia among women with HIV in the United States from 2003\u20132020","volume":"38","author":"Aldredge","year":"2022","journal-title":"AIDS"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/cid\/ciae077","article-title":"HIV, HIV-Specific Factors, and Myocardial Disease in Women","volume":"79","author":"Kato","year":"2024","journal-title":"Clin. Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.addbeh.2017.01.015","article-title":"Patterns of drug use and HIV infection among adults in a nationally representative sample","volume":"68","author":"Shiau","year":"2017","journal-title":"Addict. Behav."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11904-019-00422-z","article-title":"The association between marijuana use and HIV continuum of care outcomes: A systematic review","volume":"16","author":"Montgomery","year":"2019","journal-title":"Curr. HIV\/AIDS Rep."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1007\/s10461-025-04669-z","article-title":"Patterns of Cannabis Use among Women With HIV in the United States","volume":"29","author":"Haley","year":"2025","journal-title":"AIDS Behav."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"964","DOI":"10.15585\/mmwr.mm7130a3","article-title":"Chronic conditions among adults aged 18\u201334 years\u2014United States, 2019","volume":"71","author":"Watson","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s13365-017-0556-6","article-title":"Changing clinical phenotypes of HIV-associated neurocognitive disorders","volume":"24","author":"Sacktor","year":"2018","journal-title":"J. Neurovirol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.2105\/AJPH.2018.304864","article-title":"From the outside in: Biological mechanisms linking social and environmental exposures to chronic disease and to health disparities","volume":"109","author":"Bagby","year":"2019","journal-title":"Am. J. Public Health"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.sleh.2024.09.006","article-title":"Phenotypes of sleep health among adults with chronic heart failure in a randomized controlled trial of cognitive behavioral therapy for insomnia","volume":"10","author":"Jeon","year":"2024","journal-title":"Sleep Health"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.outlook.2019.01.003","article-title":"Precision health: Advancing symptom and self-management science","volume":"67","author":"Hickey","year":"2019","journal-title":"Nurs. Outlook"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"101996","DOI":"10.1016\/j.outlook.2023.101996","article-title":"Nurse-led approaches to address social determinants of health and advance health equity: A new framework and its implications","volume":"71","author":"Johnson","year":"2023","journal-title":"Nurs. Outlook"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"102396","DOI":"10.1016\/j.outlook.2025.102396","article-title":"Breaking the code: Using the Precision Health Model to guide research and clinical care","volume":"73","author":"Hammer","year":"2025","journal-title":"Nurs. Outlook"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"22","DOI":"10.2105\/AJPH.2019.305380","article-title":"The time is now to end the HIV epidemic","volume":"110","author":"Giroir","year":"2020","journal-title":"Am. J. Public Health"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1111\/jnu.12456","article-title":"Strengthening Inter-and Intraprofessional Collaborations to Advance Biobehavioral Symptom Science","volume":"51","author":"Starkweather","year":"2019","journal-title":"J. Nurs. Scholarsh."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/NNR.0000000000000339","article-title":"Working together to advance symptom science in the precision era","volume":"68","author":"Dorsey","year":"2019","journal-title":"Nurs. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"e491","DOI":"10.1016\/S2352-3018(20)30033-3","article-title":"Ending the HIV epidemic in the USA: An economic modelling study in six cities","volume":"7","author":"Nosyk","year":"2020","journal-title":"Lancet HIV"}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/10\/12\/332\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T05:11:45Z","timestamp":1764393105000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/10\/12\/332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,25]]},"references-count":55,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["tropicalmed10120332"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed10120332","relation":{},"ISSN":["2414-6366"],"issn-type":[{"type":"electronic","value":"2414-6366"}],"subject":[],"published":{"date-parts":[[2025,11,25]]}}}