{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:10:58Z","timestamp":1793747458537,"version":"4.6.1"},"reference-count":53,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Union-CDC Cooperative agreement","award":["NU2GGH002222"],"award-info":[{"award-number":["NU2GGH002222"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Systematic screening of household contacts (HHCs) of people with tuberculosis (TB) and starting them on either TB treatment or tuberculosis preventive treatment (TPT) reduces TB incidence. This project supported HHC management in six health facilities in Zimbabwe through the provision of CXR services, reimbursement of transport costs for HHCs, and provision of fuel and refreshments for healthcare workers involved in contact tracing. We describe TB and TPT cascades among the HHCs of index patients with all forms of TB. We enrolled 251 index patients who listed 794 HHCs: 551 (69%) HHCs of 158 index patients were traced and 520 (94%) screened for TB. Of the 502 who were referred to clinics, 362 (72%) reached the clinic. Among 520 HHCs, 324 (62%) underwent CXR screening and 18 (5%) had CXRs suggestive of TB. The yield of TB was 2.3% (12\/520), with CXR detecting eight people who had not reported TB symptoms. Of the 311 who were assessed for TPT eligibility, 126 (41%) started TPT and 119 were assessed for TPT outcomes. Of these, 111 (93%) had successful TPT outcomes. The median times to starting TB treatment and TPT were 7 days and 11 days, respectively. The intervention facilitated timely access to healthcare services and a high yield of TB detection.<\/jats:p>","DOI":"10.3390\/tropicalmed10120347","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T16:11:18Z","timestamp":1765383078000},"page":"347","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Optimization of Case Finding and Preventive Treatment Among Household Contacts of People with Tuberculosis in Zimbabwe"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7785-4576","authenticated-orcid":false,"given":"Tawanda","family":"Mapuranga","sequence":"first","affiliation":[{"name":"The Union Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0997-9799","authenticated-orcid":false,"given":"Collins","family":"Timire","sequence":"additional","affiliation":[{"name":"AIDS and TB Department, Ministry of Health and Child Care, Causeway, Harare P.O. Box CY 1122, Zimbabwe"},{"name":"The International Union Against Tuberculosis and Lung Disease (The Union), 75001 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4668-0868","authenticated-orcid":false,"given":"Ronald T.","family":"Ncube","sequence":"additional","affiliation":[{"name":"The Union Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sithabiso","family":"Dube","sequence":"additional","affiliation":[{"name":"The Union Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nqobile","family":"Mlilo","sequence":"additional","affiliation":[{"name":"The Union Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Chiteve","sequence":"additional","affiliation":[{"name":"The Union Zimbabwe Trust, 261 Diamond Road, Westgate, Harare P.O. Box CY 550, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Owen","family":"Mugurungi","sequence":"additional","affiliation":[{"name":"AIDS and TB Department, Ministry of Health and Child Care, Causeway, Harare P.O. Box CY 1122, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fungai","family":"Kavenga","sequence":"additional","affiliation":[{"name":"AIDS and TB Department, Ministry of Health and Child Care, Causeway, Harare P.O. Box CY 1122, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manners","family":"Ncube","sequence":"additional","affiliation":[{"name":"AIDS and TB Department, Ministry of Health and Child Care, Causeway, Harare P.O. Box CY 1122, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2156-3966","authenticated-orcid":false,"given":"Nicholas","family":"Siziba","sequence":"additional","affiliation":[{"name":"AIDS and TB Department, Ministry of Health and Child Care, Causeway, Harare P.O. Box CY 1122, Zimbabwe"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma Dar","family":"Berger","sequence":"additional","affiliation":[{"name":"The International Union Against Tuberculosis and Lung Disease (The Union), 75001 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9075-9616","authenticated-orcid":false,"given":"Talent","family":"Maphosa","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention, Harare 00263, Zimbabwe"},{"name":"US Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3822-5737","authenticated-orcid":false,"given":"Macarthur","family":"Charles","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Ershova","sequence":"additional","affiliation":[{"name":"US Centers for Disease Control and Prevention, 1600 Clifton Road, Atlanta, GA 30329, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3415-672X","authenticated-orcid":false,"given":"Riitta A.","family":"Dlodlo","sequence":"additional","affiliation":[{"name":"The International Union Against Tuberculosis and Lung Disease (The Union), 75001 Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"ref_1","unstructured":"World Health Organisation (2018). 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