{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:16:33Z","timestamp":1788329793153,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T00:00:00Z","timestamp":1767052800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100014588","name":"Sanofi Pasteur","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014588","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Integrated Agreement Management System","award":["23075.168655\/2017-62"],"award-info":[{"award-number":["23075.168655\/2017-62"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>In southern Brazil, dengue transmission in the state of Paran\u00e1 has shown a significant increase in the number of cases since the first recorded occurrence in 1995, with more frequent outbreaks in the west, northwest, and north of the state. We evaluated the impact of a campaign of dengue vaccination administered to a fraction of the population in 30 municipalities in the state by conducting a 15-year interrupted time-series ecological study using data obtained from an official Brazilian data register. We modeled dengue incidence using Poisson regression adjusted by covariates (demographic, climate, and epidemiological factors), allowing for specific temporal variation for each site. A reduction of 18.7% in dengue incidence rate was estimated for a vaccination coverage of 100%. Although there was an increase in the crude dengue incidence rate, considering the three-dose coverage achieved in the municipalities, we estimated an 8.2% relative reduction in the incidence rate. This reduction would increase to 17% with a hypothetical coverage of 90%. The campaign was more effective in small municipalities since they had higher vaccination coverage. These findings underscore the significant impact of the vaccination campaign on reducing dengue incidence trends across the targeted municipalities.<\/jats:p>","DOI":"10.3390\/tropicalmed11010011","type":"journal-article","created":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T13:30:52Z","timestamp":1767187852000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dengue Incidence Following Mass Vaccination: An Interrupted Time Series Study in Paran\u00e1, Brazil"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0215-2596","authenticated-orcid":false,"given":"Magda Clara Vieira da","family":"Costa-Ribeiro","sequence":"first","affiliation":[{"name":"Postgraduate Program in Microbiology, Parasitology and Pathology, Department of Basic Pathology, Federal University of Paran\u00e1, Curitiba 80060-000, Brazil"},{"name":"Postgraduate Program in Public Health, Federal University of Paran\u00e1, Curitiba 80060-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7063-2615","authenticated-orcid":false,"given":"Elias Teixeira","family":"Krainski","sequence":"additional","affiliation":[{"name":"Statistics Program, Computer, Electrical and Mathematical Sciences and Engineering Division, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela Maron de","family":"Mello","sequence":"additional","affiliation":[{"name":"Health Ministry, Bras\u00edlia 70058-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7495-5884","authenticated-orcid":false,"given":"Denise Siqueira de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Public Health, Federal University of Paran\u00e1, Curitiba 80060-240, Brazil"},{"name":"Department of Public Health, Federal University of Paran\u00e1, Curitiba 80060-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4555-4595","authenticated-orcid":false,"given":"Karin Regina","family":"Luhm","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Public Health, Federal University of Paran\u00e1, Curitiba 80060-240, Brazil"},{"name":"Department of Public Health, Federal University of Paran\u00e1, Curitiba 80060-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1134-1930","authenticated-orcid":false,"given":"Fredi Alexander","family":"Diaz-Quijano","sequence":"additional","affiliation":[{"name":"Laboratory of Causal Inference in Epidemiology\u2014LINCE-USP, Department of Epidemiology, School of Public Health, University of S\u00e3o Paulo, S\u00e3o Paulo 01246-904, 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Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane Mara Ces\u00e1rio Pereira","family":"Maluf","sequence":"additional","affiliation":[{"name":"Department of Public Health, Federal University of Paran\u00e1, Curitiba 80060-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7929-9425","authenticated-orcid":false,"given":"Gabriel","family":"Graef","sequence":"additional","affiliation":[{"name":"Foundation of the Federal University of Paran\u00e1 (FUNPAR), Curitiba 80010-200, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Ara\u00fajo de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Public Health, Federal University of Paran\u00e1, Curitiba 80060-240, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Preto","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Public 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