{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T18:48:01Z","timestamp":1783968481067,"version":"3.55.0"},"reference-count":92,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T00:00:00Z","timestamp":1772409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Background: Recent diagnostic methods have enabled the detection of often culture-negative pathogens, including anaerobic bacteria from the oral cavity. Characterising the microbial diversity and co-occurrence of bacteria in such infections is important for understanding the molecular pathophysiology in odontogenic brain abscesses. Case presentation: We describe a case of polymicrobial odontogenic brain abscess in a 59-year-old man of Vietnamese ethnicity with a documented increased risk of brain abscess due to Hereditary Haemorrhagic Telangiectasia (HHT). The microbiological diagnostic work-up included conventional culture, matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS), targeted 16S rDNA analysis using three broad-range group-specific PCR (polymerase chain reaction) assays and next-generation sequencing (NGS). A literature review was conducted, including database searches for each identified microorganism. Twelve anaerobic bacterial species were detected, among which Treponema medium, Capnocytophaga HMT-323 and Candidatus Saccharibacteria oral taxon 488 have not previously been reported in brain abscesses. In addition, we identified the extremely rare pathogens Arachnia propionica and Capnocytophaga ochracea. Conclusion: This is the first report of Ca. Saccharibacteria oral taxon 488 in a clinical sample and the first detection of any species from this phylum in a brain abscess, co-detected with A. propionica, consistent with its obligate epibiotic lifestyle. Our findings broaden the known microbial diversity associated with odontogenic brain abscesses and underscore the value of 16S rDNA NGS in characterising polymicrobial infections, particularly when fastidious or uncultivable organisms are involved.<\/jats:p>","DOI":"10.3390\/tropicalmed11030067","type":"journal-article","created":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:22:21Z","timestamp":1772551341000},"page":"67","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Odontogenic Brain Abscess in a Hereditary Haemorrhagic Telangiectasia (HHT) Patient: Case Report with a Comprehensive Literature Review"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-3844","authenticated-orcid":false,"given":"Pontus","family":"Westerstr\u00f6m","sequence":"first","affiliation":[{"name":"Department of Medical Microbiology, Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, 7006 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3455-463X","authenticated-orcid":false,"given":"Joanna Malgorzata","family":"Bivand","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Haukeland University Hospital, 5021 Bergen, Norway"},{"name":"Department of Clinical Science, University of Bergen, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4390-0370","authenticated-orcid":false,"given":"\u00d8yvind","family":"Kommedal","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Haukeland University Hospital, 5021 Bergen, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4233-5725","authenticated-orcid":false,"given":"Birgitta","family":"Ehrnstr\u00f6m","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Clinic of Medicine, St. Olavs Hospital, Trondheim University Hospital, 7006 Trondheim, Norway"},{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7006 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-412X","authenticated-orcid":false,"given":"Joakim Stray","family":"Andreassen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Neuroclinic, St. Olavs Hospital, Trondheim University Hospital, 7006 Trondheim, Norway"},{"name":"Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7006 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2489-4179","authenticated-orcid":false,"given":"Jan Egil","family":"Afset","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology, Clinic of Laboratory Medicine, St. Olavs Hospital, Trondheim University Hospital, 7006 Trondheim, Norway"},{"name":"Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, 7006 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Helweg-Larsen, J., Astradsson, A., Richhall, H., Erdal, J., Laursen, A., and Brennum, J. (2012). Pyogenic brain abscess, a 15 year survey. BMC Infect. Dis., 12.","DOI":"10.1186\/1471-2334-12-332"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1159\/000110257","article-title":"Incidence and prognosis of brain abscess in a defined population: Olmsted County, Minnesota, 1935\u20131981","volume":"10","author":"Nicolosi","year":"1991","journal-title":"Neuroepidemiology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1056\/NEJMra1301635","article-title":"Brain abscess","volume":"371","author":"Brouwer","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/ane.12167","article-title":"Cerebral abscesses among Danish patients with hereditary haemorrhagic telangiectasia","volume":"129","author":"Kjeldsen","year":"2014","journal-title":"Acta Neurol. Scand."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/(SICI)1096-8628(20000306)91:1<66::AID-AJMG12>3.0.CO;2-P","article-title":"Diagnostic criteria for hereditary hemorrhagic telangiectasia (Rendu-Osler-Weber syndrome)","volume":"91","author":"Shovlin","year":"2000","journal-title":"Am. J. Med. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1136\/thx.54.8.714","article-title":"Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations: Issues in clinical management and review of pathogenic mechanisms","volume":"54","author":"Shovlin","year":"1999","journal-title":"Thorax"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.clineuro.2011.10.036","article-title":"Cerebral abscesses in hereditary haemorrhagic telangiectasia: A clinical and microbiological evaluation","volume":"114","author":"Mathis","year":"2012","journal-title":"Clin. Neurol. Neurosurg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.jocn.2014.11.015","article-title":"Intracranial bacterial infections of oral origin","volume":"22","author":"Moazzam","year":"2015","journal-title":"J. Clin. Neurosci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/ajmg.a.10002","article-title":"The prevalence and manifestations of hereditary hemorrhagic telangiectasia in the Afro-Caribbean population of the Netherlands Antilles: A family screening","volume":"116A","author":"Westermann","year":"2003","journal-title":"Am. J. Med. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1056\/NEJM199510053331407","article-title":"Hereditary hemorrhagic telangiectasia","volume":"333","author":"Guttmacher","year":"1995","journal-title":"N. Engl. J. Med."},{"key":"ref_11","first-page":"462","article-title":"A case of congenital telangiectasis of the lung complicated by brain abscess","volume":"28","author":"Reading","year":"1932","journal-title":"Tex. State J. Med."},{"key":"ref_12","first-page":"367","article-title":"Ober arterio-venose Lungenaneurysmen und ihre Beziehungen zur Oslerschen Krankheit","volume":"81","author":"Hedinger","year":"1951","journal-title":"Schweiz. Med. Wschr."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1093.e1","DOI":"10.1016\/j.cmi.2020.03.011","article-title":"Hereditary haemorrhagic telangiectasia and pulmonary arteriovenous malformations in brain abscess patients: A nationwide, population-based matched cohort study","volume":"26","author":"Bodilsen","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"e2324","DOI":"10.1212\/WNL.0000000000207269","article-title":"Brain Abscess and Stroke in Children and Adults With Hereditary Hemorrhagic Telangiectasia: Analysis of a Large National Claims Database","volume":"100","author":"White","year":"2023","journal-title":"Neurology"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0736-4679(00)00315-2","article-title":"Brain abscess in patients with hereditary hemorrhagic telangiectasia: Case report and literature review","volume":"20","author":"Dong","year":"2001","journal-title":"J. Emerg. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1093\/brain\/awac312","article-title":"Clinical features and prognostic factors in adults with brain abscess","volume":"146","author":"Bodilsen","year":"2023","journal-title":"Brain"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.amjmed.2021.05.027","article-title":"Bacterial brain abscess: An outline for diagnosis and management","volume":"134","author":"Campioli","year":"2021","journal-title":"Am. J. Med."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1099\/jmm.0.028373-0","article-title":"Characterization of polybacterial clinical samples using a set of group-specific broad-range primers targeting the 16S rRNA gene followed by DNA sequencing and RipSeq analysis","volume":"60","author":"Kommedal","year":"2011","journal-title":"J. Med. Microbiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1128\/JCM.01228-07","article-title":"16S rRNA gene sequencing for bacterial identification in the diagnostic laboratory: Pluses, perils, and pitfalls","volume":"45","author":"Janda","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1046\/j.1365-2958.1997.6382009.x","article-title":"rpoB sequence analysis as a novel basis for bacterial identification","volume":"26","author":"Mollet","year":"1997","journal-title":"Mol. Microbiol."},{"key":"ref_21","unstructured":"CLSI (2018). Interpretive Criteria for Identification of Bacteria and Fungi by Targeted DNA Sequencing. CLSI Guideline MM18, Clinical and Laboratory Standards Institute. [2nd ed.]."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e0059821","DOI":"10.1128\/mBio.00598-21","article-title":"Managing Contamination and Diverse Bacterial Loads in 16S rRNA Deep Sequencing of Clinical Samples: Implications of the Law of Small Numbers","volume":"12","author":"Dyrhovden","year":"2021","journal-title":"mBio"},{"key":"ref_23","first-page":"657","article-title":"Dysgonic fermenter 2 infection resulting in chronic glomerulonephritis","volume":"132","author":"Archer","year":"1985","journal-title":"Can. Med. Assoc. J."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1093\/clind\/15.3.453","article-title":"Infections Due to Nocardia transvalensis: Clinical Spectrum and Antimicrobial Therapy","volume":"15","author":"McNeil","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1007\/s100960050357","article-title":"First isolation of Desulfovibrio species as part of a polymicrobial infection from a brain abscess","volume":"18","author":"Lozniewski","year":"1999","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s10096-002-0696-2","article-title":"Brain abscess due to Capnocytophaga species, Actinomyces species, and Streptococcus intermedius in a patient with cyanotic congenital heart disease","volume":"21","author":"Engelhardt","year":"2002","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1179\/joc.2004.16.5.497","article-title":"Capnocytophaga spp. brain abscess in an immunocompetent host: Problems in antimicrobial chemotherapy and literature review","volume":"16","author":"Sabbatani","year":"2004","journal-title":"J. Chemother."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1128\/JCM.01815-06","article-title":"Brain Abscess Associated with Multidrug-Resistant Capnocytophaga ochracea Infection","volume":"45","author":"Wang","year":"2007","journal-title":"J. Clin. Microbiol."},{"key":"ref_29","first-page":"79","article-title":"A case of Capnocytophaga canimorsus brain abscess secondary to dog\u2019s bite","volume":"29","author":"Ulivieri","year":"2008","journal-title":"Il G. Di Chir."},{"key":"ref_30","first-page":"162","article-title":"Cerebral abscess caused by Capnocytophaga spp in an immunocompetent subject: Case report","volume":"16","author":"Ricciardi","year":"2008","journal-title":"Le. Infez. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1086\/597578","article-title":"The expansion of the microbiological spectrum of brain abscesses with use of multiple 16S ribosomal DNA sequencing","volume":"48","author":"Armougom","year":"2009","journal-title":"Clin. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.1128\/JCM.00346-14","article-title":"Massive Parallel Sequencing Provides New Perspectives on Bacterial Brain Abscesses","volume":"52","author":"Kommedal","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"42","DOI":"10.4172\/1948-5948.1000260","article-title":"Brain Abscess Caused by Capnocytophaga Species Associated with Anti-Tumor Necrosis Factor-\u03b1 Therapy","volume":"8","author":"Chen","year":"2016","journal-title":"J. Microb. Biochem. Technol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1212\/WNL.94.15_supplement.1058","article-title":"Combined Capnocytophaga spp. and Fusobacterium Nucleatum Brain Abscess with Vibrio Cholera Infection: A Case Report (1058)","volume":"94","author":"Senetar","year":"2020","journal-title":"Neurology"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"ofab175","DOI":"10.1093\/ofid\/ofab175","article-title":"The Characteristics of Capnocytophaga Infection: 10 Years of Experience","volume":"8","author":"Chesdachai","year":"2021","journal-title":"Open Forum Infect. Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1128\/jcm.22.5.799-802.1985","article-title":"Bacteroides gracilis, an important anaerobic bacterial pathogen","volume":"22","author":"Johnson","year":"1985","journal-title":"J. Clin. Microbiol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1056\/NEJM199004193221608","article-title":"Case 16-1990: A 57-Year-Old Woman with a Thalamic Lesion and Pulmonary Arteriovenous Fistulas","volume":"322","author":"Wolpow","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1007\/s10096-008-0550-2","article-title":"Campylobacter species isolated from extra-oro-intestinal abscesses: A report of four cases and literature review","volume":"27","author":"Arents","year":"2008","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/AOG.0b013e31822468d6","article-title":"Pregnancy complicated by recurrent brain abscess after extraction of an infected tooth","volume":"118","author":"Hobson","year":"2011","journal-title":"Obs. Gynecol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1093\/cid\/cir797","article-title":"Metagenomic analysis of brain abscesses identifies specific bacterial associations","volume":"54","author":"Lonjon","year":"2012","journal-title":"Clin. Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e437","DOI":"10.1097\/IPC.0000000000001038","article-title":"Odontogenic Brain Abscess With Campylobacter gracilis and Fusobacterium nucleatum Complicated by Rupture Into the Ventricle","volume":"29","author":"Jang","year":"2021","journal-title":"Infect. Dis. Clin. Pract."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1111\/apm.13181","article-title":"Diagnostics with clinical microbiome-based identification of microorganisms in patients with brain abscesses-a prospective cohort study","volume":"129","author":"Hansen","year":"2021","journal-title":"APMIS Acta Pathol. Microbiol. Immunol. Scand."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1136\/bmj.282.6269.1035","article-title":"Brain abscess due to Arachnia propionica","volume":"282","author":"Riley","year":"1981","journal-title":"Br. Med. J. (Clin. Res. Ed.)"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"525","DOI":"10.5694\/mja11.10768","article-title":"Brain abscess due to Propionibacterium propionicum in Eisenmenger syndrome","volume":"196","author":"Chau","year":"2012","journal-title":"Med. J. Aust."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1128\/jb.78.2.164-170.1959","article-title":"Actinomyces israelii, a cause of lacrimal canaliculitis in man","volume":"78","author":"Pine","year":"1959","journal-title":"J. Bacteriol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1099\/00221287-28-2-305","article-title":"Characterization of a propionic acid producing actinomycete, Actinomyces propionicus, sp. nov","volume":"28","author":"Buchanan","year":"1962","journal-title":"J. Gen. Microbiol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1099\/00207713-19-3-267","article-title":"Reclassification of Actinomyces propionicus","volume":"19","author":"Pine","year":"1969","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1099\/00207713-38-4-354","article-title":"Reclassification of Arachnia propionica as Propionibacterium propionicus comb. nov","volume":"38","author":"Charfreitag","year":"1988","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1099\/ijsem.0.001367","article-title":"The natural history of cutaneous propionibacteria, and reclassification of selected species within the genus Propionibacterium to the proposed novel genera Acidipropionibacterium gen. nov., Cutibacterium gen. nov. and Pseudopropionibacterium gen. nov","volume":"66","author":"Scholz","year":"2016","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1099\/ijsem.0.003442","article-title":"Arachnia propionica (Buchanan and Pine 1962) Pine and Georg 1969 (Approved Lists 1980), Propionibacterium propionicum corrig. (Buchanan and Pine 1962) Charfreitag et al. 1988 and Pseudopropionibacterium propionicum (Buchanan and Pine 1962) Scholz and Kilian 2016 and the nomenclatural consequences of changes in the taxonomy of the genus Propionibacterium","volume":"69","author":"Tindall","year":"2019","journal-title":"Int J Syst Evol Microbiol."},{"key":"ref_51","unstructured":"(2026, January 05). Genus: Capnocytophaga. Available online: https:\/\/www.homd.org\/taxa\/life?rank=genus&name=Capnocytophaga&otid=901."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Suzuki, M., Imaoka, K., Kimura, M., Morikawa, S., and Maeda, K. (2023). Capnocytophaga catalasegens sp. nov., isolated from feline oral cavities. Int. J. Syst. Evol. Microbiol., 73.","DOI":"10.1099\/ijsem.0.005731"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.3201\/eid2412.ET2412","article-title":"Etymologia: Capnocytophaga canimorsus","volume":"24","author":"Henry","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cmi.2018.11.030","article-title":"The bacterial aetiology of pleural empyema. A descriptive and comparative metagenomic study","volume":"25","author":"Dyrhovden","year":"2019","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_55","unstructured":"(2026, January 05). Genus Fusobacterium. Available online: https:\/\/lpsn.dsmz.de\/genus\/fusobacterium."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s15010-015-0871-x","article-title":"Fusobacterium nucleatum infections: Clinical spectrum and bacteriological features of 78 cases","volume":"44","author":"Denes","year":"2016","journal-title":"Infection"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3171\/jns.2003.99.4.0693","article-title":"Fusobacterial brain abscess: A review of five cases and an analysis of possible pathogenesis","volume":"99","author":"Han","year":"2003","journal-title":"J. Neurosurg."},{"key":"ref_58","unstructured":"(2026, January 05). Capnocytophaga sp._HMT_323 (HMT-323). Available online: https:\/\/v31.homd.org\/taxa\/tax_description?otid=323."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1099\/00207713-31-4-432","article-title":"Wolinella gen. nov., Wolinella succinogenes (Vibrio succinogenes Wolin et al.) comb. nov., and description of Bacteroides gracilis sp. nov., Wolinella recta sp.nov., Campylobacter concisus sp. nov., and Eikenella corrodens from humans with periodontal disease","volume":"31","author":"Tanner","year":"1981","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_60","first-page":"145","article-title":"Chemotaxonomic analyses of Bacteroides gracilis and Bacteroides ureolyticus and reclassification of B. gracilis as Campylobacter gracilis comb. nov","volume":"45","author":"Vandamme","year":"1995","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"S263","DOI":"10.1093\/clinids\/16.Supplement_4.S263","article-title":"Empyema due to Bacteroides gracilis: Case report and in vitro susceptibilities to eight antimicrobial agents","volume":"16","author":"Lee","year":"1993","journal-title":"Clin. Infect. Dis."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.3201\/eid2106.142043","article-title":"Fatal bacteremia caused by Campylobacter gracilis, United States","volume":"21","author":"Shinha","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.cmi.2020.03.028","article-title":"Molecular diagnosis of polymicrobial brain abscesses with 16S-rDNA-based next-generation sequencing","volume":"27","author":"Stebner","year":"2021","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1099\/00207713-47-1-67","article-title":"Treponema medium sp. nov., isolated from human subgingival dental plaque","volume":"47","author":"Umemoto","year":"1997","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_65","unstructured":"(2026, January 05). Genus Treponema. Available online: https:\/\/lpsn.dsmz.de\/genus\/treponema."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1128\/CMR.00070-13","article-title":"The endemic treponematoses","volume":"27","author":"Giacani","year":"2014","journal-title":"Clin Microbiol Rev."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/cid\/ciad378","article-title":"Pleural Empyema Caused by Streptococcus intermedius and Fusobacterium nucleatum: A Distinct Entity of Pleural Infections","volume":"77","author":"Dyrhovden","year":"2023","journal-title":"Clin. Infect. Dis."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"e0070121","DOI":"10.1128\/Spectrum.00701-21","article-title":"Diversity of Treponema denticola and Other Oral Treponeme Lineages in Subjects with Periodontitis and Gingivitis","volume":"9","author":"Zeng","year":"2021","journal-title":"Microbiol. Spectr."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1099\/00207713-46-3-745","article-title":"Treponema maltophilum sp. nov., a small oral spirochete isolated from human periodontal lesions","volume":"46","author":"Wyss","year":"1996","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1099\/00207713-40-3-273","article-title":"Actinomyces georgiae sp. nov., Actinomyces gerencseriae sp. nov., designation of two genospecies of Actinomyces naeslundii, and inclusion of A. naeslundii serotypes II and III and Actinomyces viscosus serotype II in A. naeslundii genospecies 2","volume":"40","author":"Johnson","year":"1990","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1128\/CMR.00100-14","article-title":"Actinomyces and related organisms in human infections","volume":"28","author":"Wade","year":"2015","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_72","first-page":"457","article-title":"Treponema socranskii sp. nov., Treponema socranskii subsp. socranskii subsp. nov., Treponema socranskii subsp. buccale subsp. nov., and Treponema socranskii subsp. paredis subsp. nov. isolated from the human periodontia","volume":"34","author":"Smibert","year":"1984","journal-title":"Int. J. Syst. Evol. Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Cheng, H., Xu, L., Yang, F., Jia, L., Zhao, D., Li, H., Liu, W., Li, Y., Liu, X., and Geng, X. (2022). Case report: Meningitis and intracranial aneurysm caused by mixed infection of oral microflora dominated by anaerobes. Front. Neurol., 13.","DOI":"10.3389\/fneur.2022.889838"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Naud, S., Valles, C., Abdillah, A., Abou Chacra, L., Mekhalif, F.Z., Ibrahim, A., Caputo, A., Baudoin, J.P., Gouriet, F., and Bittar, F. (2023). Preliminary landscape of Candidatus Saccharibacteria in the human microbiome. Front. Cell Infect. Microbiol., 13.","DOI":"10.3389\/fcimb.2023.1195679"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1177\/0022034519831671","article-title":"Saccharibacteria (TM7) in the Human Oral Microbiome","volume":"98","author":"Bor","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1073\/pnas.1419038112","article-title":"Cultivation of a human-associated TM7 phylotype reveals a reduced genome and epibiotic parasitic lifestyle","volume":"112","author":"He","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1128\/MRA.01159-19","article-title":"Complete genome sequence of strain PM004, a novel cultured member of the human oral microbiome from the candidate phylum Saccharibacteria (TM7)","volume":"8","author":"Murugkar","year":"2019","journal-title":"Microbiol. Resour. Announc."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1600-051X.1998.tb02419.x","article-title":"Microbial complexes in subgingival plaque","volume":"25","author":"Socransky","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1099\/00207713-36-2-213","article-title":"Bacteroides forsythus sp. nov., a slow growing fusiform Bacteroides sp. from the human oral cavity","volume":"36","author":"Tanner","year":"1986","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-0757.2006.00184.x","article-title":"Tannerella forsythia, a periodontal pathogen entering the genomic era","volume":"42","author":"Tanner","year":"2006","journal-title":"Periodontol 2000"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2197779","DOI":"10.1080\/20002297.2023.2197779","article-title":"Current concepts in the pathogenesis of periodontitis: From symbiosis to dysbiosis","volume":"15","author":"Abdulkareem","year":"2023","journal-title":"J. Oral. Microbiol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1099\/00207713-44-2-187","article-title":"Oribaculum catoniae gen. nov., sp. nov.; Catonella morbi gen. nov., sp. nov.; Hallella seregens gen. nov., sp. nov.; Johnsonella ignava gen. nov., sp. nov.; and Dialister pneumosintes gen. nov., comb. nov., nom. rev., Anaerobic gram-negative bacilli from the human gingival crevice","volume":"44","author":"Moore","year":"1994","journal-title":"Int. J. Syst. Bacteriol."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"106911","DOI":"10.1016\/j.mimet.2024.106911","article-title":"Factors affecting the quality and reproducibility of MALDI-TOF MS identification for human Capnocytophaga species","volume":"220","author":"Algahawi","year":"2024","journal-title":"J. Microbiol. Methods."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"ofad500.277","DOI":"10.1093\/ofid\/ofad500.277","article-title":"204. Clinical and Epidemiologic Review of Capnocytophaga Infections Identified at a Public Health Reference Laboratory\u2013California, 2005\u20132021","volume":"10","author":"Kelly","year":"2023","journal-title":"Open Forum. Infect. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00203-018-1505-3","article-title":"Insights into the human oral microbiome","volume":"200","author":"Verma","year":"2018","journal-title":"Arch. Microbiol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"105360","DOI":"10.1016\/j.archoralbio.2022.105360","article-title":"The connection between brain abscess and odontogenic infections: A systematic review","volume":"135","author":"Lisboa","year":"2022","journal-title":"Arch. Oral. Biol."},{"key":"ref_87","doi-asserted-by":"crossref","unstructured":"Montemurro, N., Perrini, P., Marani, W., Chaurasia, B., Corsalini, M., Scarano, A., and Rapone, B. (2021). Multiple brain abscesses of odontogenic origin. May oral microbiota affect their development? A review of the current literature. Appl. Sci., 11.","DOI":"10.3390\/app11083316"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.oooo.2020.01.008","article-title":"Do brain abscesses have a higher incidence of odontogenic origin than previously thought?","volume":"130","author":"Hsu","year":"2020","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Daniels, J.S. (2019). Cerebral Abscess: A Complex Complication of Odontogenic Infection: A Case Report and Review of the Literature. Surgeries, 1.","DOI":"10.35702\/surg.10004"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1007\/s00784-023-04976-6","article-title":"Cerebral abscesses with odontogenic origin: A population-based cohort study","volume":"27","author":"Jespersen","year":"2023","journal-title":"Clin. Oral. Investig."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/s41579-018-0089-x","article-title":"The oral microbiota: Dynamic communities and host interactions","volume":"16","author":"Lamont","year":"2018","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Chen, Y., Huang, Z., Tang, Z., Huang, Y., Huang, M., Liu, H., Ziebolz, D., Schmalz, G., Jia, B., and Zhao, J. (2022). More Than Just a Periodontal Pathogen\u2014The Research Progress on Fusobacterium nucleatum. Front. Cell. Infect. Microbiol., 12.","DOI":"10.3389\/fcimb.2022.815318"}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/11\/3\/67\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T16:27:59Z","timestamp":1772555279000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/11\/3\/67"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":92,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2026,3]]}},"alternative-id":["tropicalmed11030067"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed11030067","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]}}}