{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:27:16Z","timestamp":1785421636091,"version":"3.56.0"},"reference-count":52,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T00:00:00Z","timestamp":1782604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Deanship of Scientific Research at Imam Mohammad Ibn Saud Islamic University","award":["IMSIU\u2212DDRSP2601"],"award-info":[{"award-number":["IMSIU\u2212DDRSP2601"]}]},{"award":["IMSIU\u2212DDRSP2601"],"award-info":[{"award-number":["IMSIU\u2212DDRSP2601"]}],"id":[{"id":"https:\/\/ror.org\/05gxjyb39","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Cystic echinococcosis (CE), a neglected zoonotic disease caused by Echinococcus granulosus sensu lato, poses a persistent public health burden in agro-pastoral regions worldwide. This study provides a large-scale epidemiological assessment of CE, highlighting sustained zoonotic transmission driven by agro-pastoral practices and human\u2013animal interactions, and supporting the urgent implementation of One Health strategies. This ten-year retrospective study (2015\u20132024) analyzed 326 surgically confirmed cases from five hospitals in Djelfa. The cumulative surgical incidence was 2.04 cases per 100,000 person-years, classifying the region as hypoendemic. Females predominated (61.96%), and individuals aged 31\u201360 years represented 47.24% of cases. Rural residence (73.62%) and dog contact (94.17%) were major risk factors, with hepatic localization dominating (88.96%). Correlation analysis showed moderate associations between rural habitat and dog contact (V = 0.46, p &lt; 0.001) and between sex and habitat (V = 0.34, p &lt; 0.001), as well as weaker but significant associations for age and cyst location (V = 0.28, p &lt; 0.001) and dog contact and cyst location (V = 0.20, p &lt; 0.05). No postoperative mortality was recorded. These findings confirm active transmission linked to agro-pastoral practices and emphasize the need for coordinated One Health control strategies.<\/jats:p>","DOI":"10.3390\/tropicalmed11070180","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T02:16:44Z","timestamp":1782699404000},"page":"180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cystic Echinococcosis in Agro-Pastoral Regions: A 10-Year Retrospective Study (2015\u20132024) and the Case for a One Health Approach"],"prefix":"10.3390","volume":"11","author":[{"given":"Messaoud","family":"Bouragba","sequence":"first","affiliation":[{"name":"Faculty of Nature and Life Sciences, Ziane Achour University, P.O. Box 3117, Djelfa 17000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Abdellaoui","sequence":"additional","affiliation":[{"name":"Faculty of Nature and Life Sciences, Ziane Achour University, P.O. Box 3117, Djelfa 17000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Saci","sequence":"additional","affiliation":[{"name":"Analytical Biochemistry and Biotechnology Laboratory, Faculty of Biological and Agronomic Sciences, Mouloud Mammeri University, Tizi-Ouzou 15000, Algeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6382-8807","authenticated-orcid":false,"given":"Nasir A.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Saad","family":"Aleissa","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8814-5957","authenticated-orcid":false,"given":"Nosiba S.","family":"Basher","sequence":"additional","affiliation":[{"name":"Biology Department, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11623, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nesrine","family":"Goumich","sequence":"additional","affiliation":[{"name":"Faculty of Nature and Life Sciences, Ziane Achour University, P.O. 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Parasitol."},{"key":"ref_4","unstructured":"World Health Organization (2025, January 31). Global Report on Neglected Tropical Diseases. Reference Number: B09040. Available online: https:\/\/www.who.int\/publications\/i\/item\/B09040."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/JCM.02420-15","article-title":"Cystic echinococcosis","volume":"54","author":"Brunetti","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"ref_6","unstructured":"World Health Organization (2025, January 31). Echinococcosis: Key Facts. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/echinococcosis."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Fasihi-Harandi, M., Budke, C.M., and Rostami, S. (2012). The Monetary Burden of Cystic Echinococcosis in Iran. PLoS Neglected Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001915"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"L\u00f6tsch, F., Budke, C.M., Auer, H., Kaczirek, K., Waneck, F., Lagler, H., and Ramharter, M. (2019). Evaluation of direct costs associated with alveolar and cystic echinococcosis in Austria. PLoS Neglected Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007110"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.4067\/S0034-98872014000800010","article-title":"Estimation of the economic impact of cystic echinococcosis in Chile and analysis of the possible causes that have hindered its eradication","volume":"142","author":"Venegas","year":"2014","journal-title":"Rev. M\u00e9dica Chile"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.2471\/BLT.09.066795","article-title":"Analysis of the economic impact of cystic echinococcosis in Spain","volume":"88","author":"Benner","year":"2010","journal-title":"Bull. World Health Organ."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.vetpar.2006.01.003","article-title":"Epidemiological Study of the Cystic Echinococcosis in Morocco","volume":"137","author":"Azlaf","year":"2006","journal-title":"Vet. Parasitol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.vetpar.2015.07.035","article-title":"Taxonomy and molecular epidemiology of Echinococcus granulosus sensu lato","volume":"213","author":"Romig","year":"2015","journal-title":"Vet. Parasitol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/00004728-198410000-00005","article-title":"Findings in hepatic involvement by Echinococcus granulosus","volume":"8","author":"Pandolfo","year":"1984","journal-title":"J. Comput. Assist. Tomogr."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1128\/CMR.16.1.18-36.2003","article-title":"Concepts in immunology and diagnosis of hydatid disease","volume":"16","author":"Zhang","year":"2003","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00436-018-6118-x","article-title":"Frequency and genetic diversity of Echinococcus granulosus sensu stricto in sheep and cattle from the steppe region of Djelfa, Algeria","volume":"18","author":"Laatamna","year":"2019","journal-title":"Parasitol. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00436-024-08176-3","article-title":"Molecular characterization and haplotypes of hydatid cyst isolates collected from humans and ruminants in Setif Province (northeast of Algeria) based on mitochondrial cytochrome C oxidase subunit 1(mt-CO1) gene sequences","volume":"123","author":"Kheninef","year":"2024","journal-title":"Parasitol. Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.patbio.2013.03.001","article-title":"Epidemiological profile of 290 cases of human cystic echinococcosis diagnosed at the CHU Mustapha in Algiers (2006 to 2011)","volume":"61","author":"Zait","year":"2013","journal-title":"Pathol. Biol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.patbio.2014.04.003","article-title":"Parasitological study of 78 cases of human cystic echinococcosis collected between 2005 and 2012 in Mustapha hospital center of Algiers","volume":"62","author":"Zait","year":"2014","journal-title":"Pathol. Biol."},{"key":"ref_19","first-page":"335","article-title":"Epidemiological profile and fertility assessment of hydatid cysts surgically removed from patients in Djelfa province, Algeria","volume":"67","author":"Laatamna","year":"2021","journal-title":"Ann. Parasitol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0001-706X(02)00272-3","article-title":"Overview of the epidemiological situation on echinococcosis in the Mediterranean region","volume":"85","author":"Seimenis","year":"2003","journal-title":"Acta Trop."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1007\/s00436-021-07223-7","article-title":"Genetic diversity of Echinococcus granulosus sensu stricto infecting humans in western Algeria","volume":"120","author":"Moussa","year":"2021","journal-title":"Parasitol. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1007\/s00436-016-4994-5","article-title":"Molecular characterization of Echinococcus granulosus sensu stricto and Echinococcus canadensis in humans and livestock from Algeria","volume":"115","author":"Zait","year":"2016","journal-title":"Parasitol. Res."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Alho, A.M., Dias, M.C., Cardo, M., Aguiar, P., and De-Carvalho, L.M. (2023). The Evolution of Cystic Echinococcosis in Humans and Ruminants in Portugal: A One Health Approach. Vet. Sci., 10.","DOI":"10.3390\/vetsci10090584"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s13071-024-06192-x","article-title":"Cystic echinococcosis in cattle and sheep caused by Echinococcus granulosus sensu stricto genotypes G1 and G3 in the USA","volume":"17","author":"Quintana","year":"2024","journal-title":"Parasites Vectors"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"133","DOI":"10.34172\/ijmpes.4176","article-title":"Investigation of prevalence and risk factors of human hydatid cyst disease in Jordan","volume":"5","author":"Ghorbani","year":"2024","journal-title":"Int. J. Med. Parasitol. Epidemiol. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"106616","DOI":"10.1016\/j.actatropica.2022.106616","article-title":"Molecular characterization of Echinococcus granulosus sensu lato genotypes in dromedary camels from extreme Sahara of Algeria","volume":"234","author":"Samari","year":"2022","journal-title":"Acta Trop."},{"key":"ref_27","first-page":"343","article-title":"Investigation into echinococcosis in Algeria, first part: Human cases of hydatid cysts","volume":"4","author":"Sevenet","year":"1926","journal-title":"Arch. De L\u2019institut Pasteur D\u2019alg\u00e9rie"},{"key":"ref_28","unstructured":"Mokhtari, L. (1966). Epidemiology of hydatid cysts in Algeria. Alg\u00e9rie M\u00e9dicale Chir., 85\u201390. (In French)."},{"key":"ref_29","first-page":"318","article-title":"Epidemiological study of hydatidosis in Algeria","volume":"57","author":"Larbaoui","year":"1979","journal-title":"La Tunis. M\u00e9dicale"},{"key":"ref_30","first-page":"48","article-title":"Hydatic cyst of the cerebral trunk","volume":"1","author":"Gasmi","year":"2005","journal-title":"J. De Neurochir."},{"key":"ref_31","first-page":"21","article-title":"Hydatic cysts of the orbit","volume":"8","author":"Tliba","year":"2008","journal-title":"J. Neurochir."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s13149-010-0083-7","article-title":"Hydatid cyst of the heart","volume":"103","author":"Fendri","year":"2010","journal-title":"Bull. De La Soci\u00e9t\u00e9 De Pathol. Exot."},{"key":"ref_33","first-page":"47","article-title":"Intra orbital hydatid cyst in children","volume":"8","author":"Yacoubi","year":"2012","journal-title":"J. De Neurochir."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"82","DOI":"10.48087\/BJMScr.2015.2119","article-title":"Hydatid cyst of the psoas","volume":"2","author":"Hamouda","year":"2015","journal-title":"Batna J. Med. Sci."},{"key":"ref_35","first-page":"47","article-title":"Cerebral hydatid cysts","volume":"1","author":"Samai","year":"2015","journal-title":"Cas. Clin."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.48087\/BJMSoa.2016.3208","article-title":"Cardiac hydatid cyst surgery","volume":"3","author":"Lakehal","year":"2016","journal-title":"Batna J. Med. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"59","DOI":"10.48087\/BJMScr.2019.6118","article-title":"Hydatid cyst of the heart in children","volume":"6","author":"Baya","year":"2019","journal-title":"Batna J. Med. Sci."},{"key":"ref_38","first-page":"118","article-title":"Ruptured right ventricular hydatid cyst","volume":"28","author":"Boukerroucha","year":"2020","journal-title":"J. Alg\u00e9rien M\u00e9d."},{"key":"ref_39","first-page":"27","article-title":"Cardiac hydatid cyst interfering with coronary perfusion","volume":"29","author":"Boukerroucha","year":"2021","journal-title":"J. Alg\u00e9rien M\u00e9d."},{"key":"ref_40","first-page":"43","article-title":"Hydatic cyst: Case study","volume":"18","author":"Bouchenaki","year":"2023","journal-title":"J. De Neurochir."},{"key":"ref_41","first-page":"82","article-title":"Isolated hydatid cyst with cervico-facial location","volume":"30","author":"Messaoudi","year":"2024","journal-title":"J. Alg\u00e9rien M\u00e9d."},{"key":"ref_42","first-page":"91","article-title":"Human hydatidosis in Benghazi","volume":"9","year":"2013","journal-title":"Egypt. J. Exp. Biol."},{"key":"ref_43","first-page":"33","article-title":"Epidemiology of hydatidosis in Morocco","volume":"31","author":"Belamalem","year":"2014","journal-title":"Antropo"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1179\/000349802125000952","article-title":"Epidemiology of Echinococcus granulosus in Libya","volume":"96","author":"Tashani","year":"2002","journal-title":"Ann. Trop. Med. Parasitol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0001-706X(02)00213-9","article-title":"Echinococcosis in Turkey","volume":"85","author":"Altintas","year":"2003","journal-title":"Acta Trop."},{"key":"ref_46","first-page":"4261","article-title":"Human cystic echinococcosis in France","volume":"115","author":"Million","year":"2016","journal-title":"Parasitol. Res."},{"key":"ref_47","first-page":"491","article-title":"Diagnosis of human cystic echinococcosis","volume":"52","year":"2022","journal-title":"J. Egypt. Soc. Parasitol."},{"key":"ref_48","first-page":"25","article-title":"Seroepidemiology of human hydatidosis","volume":"7","author":"Garedaghi","year":"2009","journal-title":"Iran. J. Epidemiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s41182-020-00238-3","article-title":"Human cystic echinococcosis in Iran","volume":"48","author":"Shahriarirad","year":"2020","journal-title":"Trop. Med. Health"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1007\/s11605-018-3971-y","article-title":"Retrospective study of cystic echinococcosis in a recent cohort of a referral center for liver surgery","volume":"23","author":"Salvador","year":"2019","journal-title":"J. Gastrointest. Surg."},{"key":"ref_51","first-page":"218","article-title":"Study of operated hydatidosis cases in Iran","volume":"35","author":"Nourjah","year":"2004","journal-title":"Southeast Asian J. Trop. Med. Public Health"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"e71011","DOI":"10.1002\/ppul.71011","article-title":"Pulmonary hydatid cyst rupture","volume":"60","author":"Rajvanshi","year":"2025","journal-title":"Pediatr. Pulmonol."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/11\/7\/180\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T03:57:53Z","timestamp":1782705473000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/11\/7\/180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,28]]},"references-count":52,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["tropicalmed11070180"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed11070180","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,28]]}}}