{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T04:59:51Z","timestamp":1785214791590,"version":"3.55.0"},"reference-count":15,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003196","name":"Italian Ministry of Health","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trop. Med. Infect. Dis.","TropicalMed"],"abstract":"<jats:p>In 2025, Rome hosted the Catholic Jubilee, recording over 33 million cumulative pilgrim attendances while simultaneously facing the death of Pope Francis, the election of Pope Leo XIV, and a regional West Nile Virus (WNV) outbreak. This commentary describes the Lazio Region\u2019s preparedness strategy, based on adapting an existing Hub-and-Spoke infectious diseases network integrating surveillance with Regional Service for Epidemiology, Surveillance and Control of Infectious Diseases (SERESMI) laboratory support, telemedicine, and clinical management. Preparatory measures included an additional Hub, updated syndromic pathways, multidisciplinary coordination, and enhanced surveillance. Emergency department visits increased by 14.8%, while the proportion of infectious syndromes remained stable. This experience highlights the potential value of strengthening existing healthcare networks for mass gathering preparedness.<\/jats:p>","DOI":"10.3390\/tropicalmed11080211","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T01:26:23Z","timestamp":1785115583000},"page":"211","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Enhancing Infectious Disease Preparedness in Rome: The Lazio Regional Network During the 2025 Jubilee"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7784-2511","authenticated-orcid":false,"given":"Gaetano","family":"Maffongelli","sequence":"first","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5160-9743","authenticated-orcid":false,"given":"Alessandra","family":"D\u2019Abramo","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Binetti","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Scorzolini","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Palazzolo","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3972-8301","authenticated-orcid":false,"given":"Gabriella","family":"De Carli","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Agresta","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Vairo","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-8712","authenticated-orcid":false,"given":"Emanuele","family":"Nicastri","sequence":"additional","affiliation":[{"name":"National Institute for Infectious Diseases \u2018Lazzaro Spallanzani\u2019 IRCCS, Via Portuense 292, 00149 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (WHO) (2026, May 20). 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