{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:59:58Z","timestamp":1785387598096,"version":"3.55.0"},"reference-count":13,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:00:00Z","timestamp":1785196800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"crossref","award":["2024YFC2311500"],"award-info":[{"award-number":["2024YFC2311500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People\u2019s Republic of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Shanghai Municipal Disease Control and Prevention Bureau","award":["2025JZ14"],"award-info":[{"award-number":["2025JZ14"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Trop. Med. Infect. Dis.","TropicalMed"],"abstract":"<jats:p>Introduction: Historically, human infections with clade Ia monkeypox virus (MPXV) primarily occurred through zoonotic transmission with limited secondary human-to-human transmission. Recent studies suggest increasing evidence of human-to-human transmission of some clade Ia lineages. This report documents the first imported clade Ia mpox case in Shanghai, representing the second documented case in China. Methods: Patient demographics, clinical profiles, epidemiological history, and close contacts were obtained through interviews with the patient and attending physicians. Clinical specimens were collected for real-time fluorescent quantitative polymerase chain reaction (qPCR) and whole-genome sequencing. Contact tracing was implemented, involving a 21-day health monitoring of close contacts. Results: The patient presented with moderate symptoms, including fever, rash, and respiratory manifestations. Genome sequencing identified the virus as clade Ia, showing 99.96% nucleotide identity to a strain from the Democratic Republic of Congo (DRC). Eight close contacts were identified with no secondary infection reported. Conclusions: This case was confirmed as an imported clade Ia mpox case originating in the DRC. The \u201cfour JOINTs\u201d cross-agency collaborative mechanism between the CDC and customs played a significant role in effectively stopping local transmission. Challenges in remote investigation highlight the need for stronger international collaboration. Establishing an integrated \u201cearly warning-control-tracking\u201d system, coupled with public health intervention, is crucial for reducing importation risks and safeguarding national health security.<\/jats:p>","DOI":"10.3390\/tropicalmed11080212","type":"journal-article","created":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T07:55:41Z","timestamp":1785225341000},"page":"212","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Successful Cross-Agency Model for Collaborative Response to Imported Infectious Disease: Investigation and Management of the First Confirmed Clade Ia Mpox Case in Shanghai, China"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5747-7932","authenticated-orcid":false,"given":"Zilian","family":"Cao","sequence":"first","affiliation":[{"name":"Surveillance and Early Warning Institute, Shanghai Municipal Center for Disease Control & Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Xu","sequence":"additional","affiliation":[{"name":"Emergency Management Department, Shanghai Municipal Center for Disease Control & Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Huang","sequence":"additional","affiliation":[{"name":"Emergency Management Department, Shanghai Municipal Center for Disease Control & Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Shen","sequence":"additional","affiliation":[{"name":"Center Management, Shanghai Pudong New Area Center for Disease Control & Prevention (Shanghai Pudong New Area Health Supervision Institute), Shanghai 200136, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Xin","sequence":"additional","affiliation":[{"name":"Department of Tuberculosis and AIDS Prevention & Control, Shanghai Pudong New Area Center for Disease Control & Prevention (Shanghai Pudong New Area Health Supervision Institute), Shanghai 200136, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Ai","sequence":"additional","affiliation":[{"name":"Institute of Pathogen Biology and Testing, Shanghai Municipal Center for Disease Control & Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Pan","sequence":"additional","affiliation":[{"name":"Institute of Infectious Disease Prevention and Control, Shanghai Municipal Center for Disease Control & Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huanyu","family":"Wu","sequence":"additional","affiliation":[{"name":"Center Management, Shanghai Municipal Center for Disease Control & Prevention, Shanghai 201107, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,28]]},"reference":[{"key":"ref_1","first-page":"593","article-title":"A human infection caused by monkeypox virus in Basankusu Territory, Democratic Republic of the Congo","volume":"46","author":"Ladnyj","year":"1972","journal-title":"Bull. 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Commun."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/s43856-025-01247-1","article-title":"Mpox due to monkeypox virus clade Ia infection detected outside of Africa: A case study","volume":"5","author":"Fahey","year":"2025","journal-title":"Commun. Med."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1016\/j.cmi.2023.09.004","article-title":"Clinical review of human mpox","volume":"29","author":"Ogoina","year":"2023","journal-title":"Clin. Microbiol. Infect."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/11\/8\/212\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T04:25:49Z","timestamp":1785385549000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/11\/8\/212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,28]]},"references-count":13,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["tropicalmed11080212"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed11080212","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,28]]}}}