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Med. Infect. Dis.","TropicalMed"],"abstract":"<jats:p>(1) Background: Snake bite envenomation is a neglected disease that affects impoverished and rural areas, causing deaths and physical sequelae. (2) Objective: A novel series of eight 1,2,3-triazole compounds, AM50, AM51, AM52, AM53, AM54, AM55, AM56, and AM57, were synthesized and assessed as inhibitors of toxic activities of B. jararacussu venom. Methods: B. jararacussu venom was pre-incubated with each of the compounds and after the coagulant, proteolytic, hemorrhagic, edematogenic, and lethal activities were assessed. The structure of compounds was analyzed by NMR and FT-IR spectroscopy techniques, and toxicity was predicted through OSIRIS and SwissADME. (3) Results: AM56 and AM57 inhibited the plasma coagulant and prevented hemorrhagic activity of the venom. Proteolysis and hemorrhage were inhibited by AM52, AM54, AM55, and AM56 (20\u201330%), as well as AM50, AM51, and AM57 (30\u201360%). AM57 fully protected the mice from death caused by venom, and AM50, AM53\u2013AM57 inhibited edema of venom by 10\u201320%; AM51 and AM52 did not inhibit edema. In silico analysis of compounds revealed satisfactory parameters for drug discovery. (4) Conclusions: 1,2,3\u2013triazole compounds inhibited the major toxic activities of B. jararacussu venom and should be considered as a lead for further investigation as adjunct of antivenom therapeutics.<\/jats:p>","DOI":"10.3390\/tropicalmed11080224","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T08:09:36Z","timestamp":1786435776000},"page":"224","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exploiting the Property of a New Series of 1,2,3-Triazole Compounds as Inhibitors of In Vivo and In Vitro Toxic Effects Caused by Bothrops jararacussu Snake Venom"],"prefix":"10.3390","volume":"11","author":[{"given":"Aldo Rodrigues da","family":"Silva","sequence":"first","affiliation":[{"name":"Instituto de Biologia, Universidade Federal Fluminense, Niter\u00f3i 24020\u2013141, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Cl\u00e1udia Rodrigues da","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Universidade Federal Fluminense, Niter\u00f3i 24020\u2013141, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eladio Flores","family":"Sanchez","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Ezequiel Dias, Belo Horizonte 30510\u2013010, MG, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5010-2852","authenticated-orcid":false,"given":"Gabriel Alves Souto de","family":"Aquino","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2166-766X","authenticated-orcid":false,"given":"Vitor Francisco","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Faculdade de Farm\u00e1cia, Laborat\u00f3rio Inova\u00e7\u00e3o em Qu\u00edmica e Tecnologia Farmac\u00eautica, Universidade Federal Fluminense, Niter\u00f3i 24220-900, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-0888","authenticated-orcid":false,"given":"Sabrina Baptista","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Org\u00e2nica, Instituto de Qu\u00edmica, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21949-900, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5265-5258","authenticated-orcid":false,"given":"Andr\u00e9 Lopes","family":"Fuly","sequence":"additional","affiliation":[{"name":"Instituto de Biologia, Universidade Federal Fluminense, Niter\u00f3i 24020\u2013141, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s40409-017-0127-6","article-title":"Snakebite envenomation turns again into a neglected tropical disease!","volume":"23","author":"Chippaux","year":"2017","journal-title":"J. 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