{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T17:16:54Z","timestamp":1772039814088,"version":"3.50.1"},"reference-count":69,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000288","name":"Royal Society","doi-asserted-by":"publisher","award":["AA130107"],"award-info":[{"award-number":["AA130107"]}],"id":[{"id":"10.13039\/501100000288","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M019780\/1"],"award-info":[{"award-number":["MR\/M019780\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Mass drug administration (MDA) for control of schistosomiasis is likely to affect transmission dynamics through a combination of passive vaccination and reduction of local transmission intensity. This is indicated in phenomenological models of immunity and the impact of MDA, yet immunity parameters in these models are not validated by empirical data that reflects protective immunity to reinfection. There is significant empirical evidence supporting the role of IgE in acquired protective immunity. This is proposed to be a form of delayed concomitant immunity, driven at least in part by protective IgE responses to the tegument allergen-like (TAL) family of proteins. Specific questions have arisen from modeling studies regarding the strength and duration of the protective immune response. At present, field studies have not been specifically designed to address these questions. There is therefore a need for field studies that are explicitly designed to capture epidemiological effects of acquired immunity to elucidate these immunological interactions. In doing so, it is important to address the discourse between theoretical modelers and immuno-epidemiologists and develop mechanistic models that empirically define immunity parameters. This is of increasing significance in a climate of potential changing transmission dynamics following long-term implementation of MDA.<\/jats:p>","DOI":"10.3390\/tropicalmed2030042","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T11:32:27Z","timestamp":1503487947000},"page":"42","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Interdependence between Schistosome Transmission and Protective Immunity"],"prefix":"10.3390","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0502-7355","authenticated-orcid":false,"given":"Rebecca","family":"Oettle","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shona","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1017\/S0031182098003576","article-title":"Adult resistance to schistosomiasis mansoni: Age-dependence of reinfection remains constant in communities with diverse exposure patterns","volume":"118","author":"Kabatereine","year":"1999","journal-title":"Parasitology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1038\/15169","article-title":"Seeking the ghost of worms past","volume":"5","author":"Woolhouse","year":"1999","journal-title":"Nat. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1038\/351757a0","article-title":"Acquired immunity and epidemiology of Schistosoma haematobium","volume":"351","author":"Woolhouse","year":"1991","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1017\/S003118200007414X","article-title":"On the use of age-intensity data to detect immunity to parasitic infections, with special reference to Schistosoma mansoni in Kenya","volume":"105","author":"Fulford","year":"1992","journal-title":"Parasitology"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0001-706X(96)00039-3","article-title":"Dynamic aspects of morbidity and acquired immunity in schistosomiasis control","volume":"62","author":"Chan","year":"1996","journal-title":"Acta Trop."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1086\/517456","article-title":"Chemotherapy accelerates the development of acquired immune responses to Schistosoma haematobium infection","volume":"178","author":"Mutapi","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/315493a0","article-title":"Herd immunity to helminth infection and implications for parasite control","volume":"315","author":"Anderson","year":"1985","journal-title":"Nature"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1365-3156.2007.01842.x","article-title":"Microgeographical and tribal variations in water contact and Schistosoma mansoni exposure within a Ugandan fishing community","volume":"12","author":"Fulford","year":"2007","journal-title":"Trop. Med. Int. Health"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0001-706X(91)90077-W","article-title":"On the application of mathematical models of schistosome transmission dynamics. I. Natural transmission","volume":"49","author":"Woolhouse","year":"1991","journal-title":"Acta Trop."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0001-706X(92)90076-A","article-title":"On the application of mathematical models of schistosome transmission dynamics. II. Control","volume":"50","author":"Woolhouse","year":"1992","journal-title":"Acta Trop."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1017\/S003118209800331X","article-title":"Heterogeneities in schistosome transmission dynamics and control","volume":"117","author":"Woolhouse","year":"1998","journal-title":"Parasitology"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"aaa4339","DOI":"10.1126\/science.aaa4339","article-title":"Modeling infectious disease dynamics in the complex landscape of global health","volume":"347","author":"Heesterbeek","year":"2015","journal-title":"Science"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1186\/s13071-015-1157-y","article-title":"What is required in terms of mass drug administration to interrupt the transmission of schistosome parasites in regions of endemic infection?","volume":"8","author":"Anderson","year":"2015","journal-title":"Parasit Vectors"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1186\/s13071-016-1681-4","article-title":"Refined stratified-worm-burden models that incorporate specific biological features of human and snail hosts provide better estimates of Schistosoma diagnosis, transmission, and control","volume":"9","author":"Gurarie","year":"2016","journal-title":"Parasit Vectors"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.epidem.2017.02.003","article-title":"A comparison of two mathematical models of the impact of mass drug administration on the transmission and control of schistosomiasis","volume":"18","author":"Truscott","year":"2017","journal-title":"Epidemics"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1111\/j.1461-0248.2012.01836.x","article-title":"Model-guided fieldwork: Practical guidelines for multidisciplinary research on wildlife ecological and epidemiological dynamics","volume":"15","author":"Restif","year":"2012","journal-title":"Ecol. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0001-706X(03)00065-2","article-title":"Modelling and simulation of a schistosomiasis infection with biological control","volume":"87","author":"Allen","year":"2003","journal-title":"Acta Trop."},{"key":"ref_18","unstructured":"Hackett, L.W. (1937). Malaria in Europe: An Ecological Study, Oxford University Press."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/bs.apar.2016.06.003","article-title":"Studies of the transmission dynamics, mathematical model development and the control of schistosome parasites by mass drug administration in human communities","volume":"94","author":"Anderson","year":"2016","journal-title":"Adv. Parasitol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Mitchell, K.M., Mutapi, F., Mduluza, T., Midzi, N., Savill, N.J., and Woolhouse, M.E.J. (2014). Predicted impact of mass drug administration on the development of protective immunity against Schistosoma haematobium. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003059"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13071-015-1144-3","article-title":"Modelling control of Schistosoma haematobium infection: Predictions of the long-term impact of mass drug administration in Africa","volume":"8","author":"Gurarie","year":"2015","journal-title":"Parasit. Vectors"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1006\/jtbi.1997.0479","article-title":"Acquired immunity on a schistosomiasis transmission model\u2014Fitting the data","volume":"188","author":"Yang","year":"1997","journal-title":"J. Theor. Biol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1017\/S0031182004006341","article-title":"Heterogeneous model of schistosomiasis transmission and long-term control: The combined influence of spatial variation and age-dependent factors on optimal allocation of drug therapy","volume":"130","author":"Gurarie","year":"2005","journal-title":"Parasitology"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Gurarie, D., and King, C.H. (2014). Population biology of Schistosoma mating, aggregation, and transmission breakpoints: More reliable model analysis for the end-game in communities at risk. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0115875"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e42","DOI":"10.1016\/S1473-3099(16)30475-3","article-title":"Human schistosomiasis in the post-mass drug administration era","volume":"17","author":"Mutapi","year":"2017","journal-title":"Lancet Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-3024.1992.tb00029.x","article-title":"A theoretical framework for the immunoepidemiology of helminth infection","volume":"14","author":"Woolhouse","year":"1992","journal-title":"Parasite Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1128\/IAI.00012-09","article-title":"Immunoglobulin E (IgE) responses to paramyosin predict resistance to reinfection with Schistosoma japonicum and are attenuated by IgG4","volume":"77","author":"Jiz","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/349243a0","article-title":"Human IgE, IgG4 and resistance to reinfection with Schistosoma haematobium","volume":"349","author":"Hagan","year":"1991","journal-title":"Nature"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1002\/eji.1830220622","article-title":"Immunity after treatment of human schistosomiasis: Association between IgE antibodies to adult worm antigens and resistance to reinfection","volume":"22","author":"Dunne","year":"1992","journal-title":"Eur. J. Immunol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1017\/S0031182000053956","article-title":"Immunity in human schistosomiasis mansoni: Prevention by blocking antibodies of the expression of immunity in young children","volume":"94","author":"Butterworth","year":"1987","journal-title":"Parasitology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1093\/infdis\/168.4.1000","article-title":"Resistance to Schistosoma mansoni in humans: Influence of the IgE\/IgG4 balance and IgG2 in immunity to reinfection after chemotherapy","volume":"168","author":"Demeure","year":"1993","journal-title":"J. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"4264","DOI":"10.1128\/IAI.00641-12","article-title":"Progressive cross-reactivity in IgE responses: An explanation for the slow development of human immunity to schistosomiasis?","volume":"80","author":"Fitzsimmons","year":"2012","journal-title":"Infect. Immun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/0035-9203(67)90102-2","article-title":"Resistance to experimental infection with Schistosoma mansoni in rhesus monkeys induced by the transfer of adult worms","volume":"61","author":"Smithers","year":"1967","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/0035-9203(84)90283-9","article-title":"Dynamics of Schistosoma haematobium infection in a Gambian community. III. Acquisition and loss of infection","volume":"78","author":"Wilkins","year":"1984","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/S0031182000080896","article-title":"A statistical approach to schistosome population dynamics and estimation of the life-span of Schistosoma mansoni in man","volume":"110","author":"Fulford","year":"1995","journal-title":"Parasitology"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1128\/iai.64.10.4042-4046.1996","article-title":"Human immunoglobulin E responses to a recombinant 22.6-kilodalton antigen from Schistosoma mansoni adult worms are associated with low intensities of reinfection after treatment","volume":"64","author":"Webster","year":"1996","journal-title":"Infect. Immun."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Fitzsimmons, C.M., Jones, F.M., Stearn, A., Chalmers, I.W., Hoffmann, K.F., Wawrzyniak, J., Wilson, S., Kabatereine, N.B., Dunne, D.W., and Oliveira, S.C. (2012). The Schistosoma mansoni tegumental-allergen-like (TAL) protein family: Influence of developmental expression on human IgE responses. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001593"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1128\/IAI.00748-12","article-title":"Effects of treatment on IgE responses against parasite allergen-like proteins and immunity to reinfection in childhood schistosome and hookworm coinfections","volume":"81","author":"Jones","year":"2013","journal-title":"Infect. Immun."},{"key":"ref_39","first-page":"362","article-title":"Schistosoma mansoni infection in preschool-aged children: Development of immunoglobulin E and immunoglobulin G4 responses to parasite allergen-like proteins","volume":"207","author":"Jones","year":"2012","journal-title":"J. Infect. Dis."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Cook, P.C., Aynsley, S.A., Turner, J.D., Jenkins, G.R., Van Rooijen, N., Leeto, M., Brombacher, F., and Mountford, A.P. (2011). Multiple helminth infection of the skin causes lymphocyte hypo-responsiveness mediated by Th2 conditioning of dermal myeloid cells. PLoS Pathog., 7.","DOI":"10.1371\/journal.ppat.1001323"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.4269\/ajtmh.2006.75.1053","article-title":"Higher percentages of circulating mast cell precursors correlate with susceptibility to reinfection with Schistosoma mansoni","volume":"75","author":"Mwinzi","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/367183a0","article-title":"High-affinity IgE receptor on eosinophils is involved in defence against parasites","volume":"367","author":"Lamkhioued","year":"1994","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1365-3024.1985.tb00106.x","article-title":"Eosinophilia and resistance to Schistosoma haematobium in man","volume":"7","author":"Hagan","year":"1985","journal-title":"Parasite Immunol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1128\/IAI.74.4.2169-2176.2006","article-title":"Correlation between eosinophils and protection against reinfection with Schistosoma mansoni and the effect of human immunodeficiency virus type 1 coinfection in humans","volume":"74","author":"Mwinzi","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0140-6736(02)09781-7","article-title":"Resistance to reinfection with Schistosoma mansoni in occupationally exposed adults and effect of HIV-1 co-infection on susceptibility to schistosomiasis: A longitudinal study","volume":"360","author":"Karanja","year":"2002","journal-title":"Lancet"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Black, C.L., Mwinzi, P.N.M., Muok, E.M.O., Abudho, B., Fitzsimmons, C.M., Dunne, D.W., Karanja, D.M.S., Secor, W.E., and Colley, D.G. (2010). Influence of exposure history on the immunology and development of resistance to human schistosomiasis mansoni. PLoS Negl. Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000637"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1086\/595792","article-title":"Circulating CD23+ B cell subset correlates with the development of resistance to Schistosoma mansoni reinfection in occupationally exposed adults who have undergone multiple treatments","volume":"199","author":"Mwinzi","year":"2009","journal-title":"J. Infect. Dis."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1086\/653828","article-title":"Increases in levels of Schistosome-specific immunoglobulin E and CD23+ B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni","volume":"202","author":"Black","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Pinot De Moira, A., Fulford, A.J.C., Kabatereine, N.B., Ouma, J.H., Booth, M., Dunne, D.W., and Quinnell, R.J. (2010). Analysis of complex patterns of human exposure and immunity to Schistosomiasis mansoni: The influence of age, sex, ethnicity and IgE. PLoS Negl. Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000820"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/infdis\/jiu234","article-title":"Suppression of basophil histamine release and other IgE-dependent responses in childhood Schistosoma mansoni\/hookworm coinfection","volume":"210","author":"Fitzsimmons","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/0035-9203(86)90268-3","article-title":"Immune responses and immunoregulation in relation to human schistosomiasis in Egypt. III. Immunity and longitudinal studies of in vitro responsiveness after treatment","volume":"80","author":"Colley","year":"1986","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1086\/515630","article-title":"Increased interleukin-4 and interleukin-5 production in response to Schistosoma haematobium adult worm antigens correlates with lack of reinfection after treatment","volume":"178","author":"Medhat","year":"1998","journal-title":"J. Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1086\/422604","article-title":"Increases in human T helper 2 cytokine responses to Schistosoma mansoni worm and worm-tegument antigens are induced by treatment with praziquantel","volume":"190","author":"Joseph","year":"2004","journal-title":"J. Infect. Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1086\/344352","article-title":"Immune responses induced by repeated treatment do not result in protective immunity to Schistosoma haematobium: Interleukin (IL)\u20135 and IL-10 responses","volume":"186","author":"Borrmann","year":"2002","journal-title":"J. Infect. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4984","DOI":"10.1128\/iai.61.12.4984-4993.1993","article-title":"Immunity after treatment of human schistosomiasis: Association between cellular responses and resistance to reinfection","volume":"61","author":"Roberts","year":"1993","journal-title":"Infect. Immun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"5490","DOI":"10.4049\/jimmunol.177.8.5490","article-title":"Increased human IgE induced by killing Schistosoma mansoni in vivo is associated with pretreatment Th2 cytokine responsiveness to worm antigens","volume":"177","author":"Walter","year":"2006","journal-title":"J. Immunol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1128\/IAI.72.7.4023-4030.2004","article-title":"Chemotherapy for schistosomiasis in Ugandan fishermen: Treatment can cause a rapid increase in interleukin-5 levels in plasma but decreased levels of eosinophilia and worm-specific immunoglobulin E","volume":"72","author":"Fitzsimmons","year":"2004","journal-title":"Infect. Immun."},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Wilson, S., Jones, F.M., Fofana, H.K.M., Doucour\u00e9, A., Landour\u00e9, A., Kimani, G., Mwatha, J.K., Sacko, M., Vennervald, B.J., and Dunne, D.W. (2013). Rapidly boosted plasma IL-5 induced by treatment of human schistosomiasis haematobium is dependent on antigen dose, IgE and eosinophils. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002149"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"French, M.D., Churcher, T.S., Gambhir, M., Fenwick, A., Webster, J.P., Kabatereine, N.B., and Bas\u00e1\u00f1ez, M.G. (2010). Observed reductions in Schistosoma mansoni transmission from large-scale administration of praziquantel in Uganda: A mathematical modelling study. PLoS Negl. Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000897"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1186\/s13071-015-1138-1","article-title":"Estimation of changes in the force of infection for intestinal and urogenital schistosomiasis in countries with schistosomiasis control initiative-assisted programmes","volume":"8","author":"French","year":"2015","journal-title":"Parasit. Vectors"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"338","DOI":"10.4269\/ajtmh.1996.55.338","article-title":"Age-dependent reduction of schistosome fecundity in Schistosoma haematobium but not Schistosoma mansoni infections in humans","volume":"55","author":"Agnew","year":"1996","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1093\/infdis\/jiu374","article-title":"Human Schistosoma haematobium antifecundity immunity is dependent on transmission intensity and associated with immunoglobulin G1 to worm-derived antigens","volume":"210","author":"Wilson","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_63","first-page":"1","article-title":"Biology of IgE production: IgE cell differentiation and the memory of IgE responses","volume":"388","author":"He","year":"2015","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/infdis\/jit826","article-title":"Posttreatment changes in cytokines induced by Schistosoma mansoni egg and worm antigens: Dissociation of immunity- and morbidity-associated Type 2 responses","volume":"209","author":"Wilson","year":"2014","journal-title":"J. Infect. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/ni.3508","article-title":"Autonomous membrane IgE signaling prevents IgE-memory formation","volume":"17","author":"Haniuda","year":"2016","journal-title":"Nat. Immunol."},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Jimenez-Saiz, R., Chu, D.K., Mandur, T.S., Walker, T.D., Gordon, M.E., Chaudhary, R., Koenig, J., Saliba, S., Galipeau, H.J., and Utley, A. (2017). Lifelong memory responses perpetuate humoral TH 2 immunity and anaphylaxis in patients with food allergy. J. Allergy Clin. Immunol.","DOI":"10.1016\/j.jaci.2017.01.018"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/all.12563","article-title":"IgE+ B cells are scarce, but allergen-specific B cells with a memory phenotype circulate in patients with allergic rhinitis","volume":"70","author":"Wong","year":"2015","journal-title":"Allergy"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1017\/S003118209900534X","article-title":"Stochastic simulation and the detection of immunity to schistosome infections","volume":"120","author":"Chan","year":"2000","journal-title":"Parasitology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1017\/S0950268800058453","article-title":"The development of an age structured model for schistosomiasis transmission dynamics and control and its validation for Schistosoma mansoni","volume":"115","author":"Chan","year":"1995","journal-title":"Epidemiol. Infect."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/2\/3\/42\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:43:02Z","timestamp":1760208182000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/2\/3\/42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":69,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9]]}},"alternative-id":["tropicalmed2030042"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed2030042","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]}}}