{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T21:03:14Z","timestamp":1793134994765,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T00:00:00Z","timestamp":1503446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008391","name":"UBS Optimus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Federal office of food safety and veterinary affairs, Switzerland"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>This study compares data on animal rabies cases from the Chadian national rabies laboratory, hosted at the Insitut de Recherche en Elevage pour le Developpement (IRED), with bite case reporting from health facilities. The data collection accompanied a mass dog vaccination intervention over two years in N\u2019Djam\u00e9na, Chad. This allowed for a comparison of the dynamics of the incidence of animal rabies cases, human bite exposure incidence and post-exposure prophylaxis (PEP) demand during a dog rabies elimination attempt. Following the mass vaccination, the monthly animal rabies incidence dropped from 1.1\/10,000 dogs, as observed prior to the campaign in 2012, to 0.061\/10,000 dogs in 2014. However, the PEP demand was found to be largely unaffected. The suspicion of the rabies exposure as reported by health personnel in most cases did not reflect the status of the biting animal but rather the severity of the bite wound, resulting in inappropriate PEP recommendations. In addition, the levels of reporting dead or killed animals to the rabies laboratory was found to be very low. These results reveal a profound lack of communication between health facilities and veterinary structures and the absence of an integrated bite case management (IBCM) approach. Improved communication between human health and veterinary workers is imperative to prevent human rabies deaths through the appropriate use of PEP and to further translate success in animal rabies control into cost savings for the public health sector through a lower PEP demand. Improved training of health and veterinary personnel and the sensitisation of the public are needed to achieve good IBCM practice, to increase the rate of diagnostic testing, to provide adequate and timely PEP, and to reduce the wastage of scarce vaccine resources.<\/jats:p>","DOI":"10.3390\/tropicalmed2030043","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T11:32:27Z","timestamp":1503487947000},"page":"43","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["The Importance of a Participatory and Integrated One Health Approach for Rabies Control: The Case of N\u2019Djam\u00e9na, Chad"],"prefix":"10.3390","volume":"2","author":[{"given":"Monique","family":"Lechenne","sequence":"first","affiliation":[{"name":"Swiss Tropical and Public Health Institute, P.O.Box, Socinstrasse 57, CH-4002 Basel, Switzerland"},{"name":"University of Basel, Petersplatz 1, CH-4051 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolande","family":"Mindekem","sequence":"additional","affiliation":[{"name":"Centre de Support en Sant\u00e9 International, BP: 972, Moursal, N\u2019Djam\u00e9na, Chad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9raphin","family":"Madjadinan","sequence":"additional","affiliation":[{"name":"Centre de Support en Sant\u00e9 International, BP: 972, Moursal, N\u2019Djam\u00e9na, Chad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Assandi","family":"Oussigu\u00e9r\u00e9","sequence":"additional","affiliation":[{"name":"Institut de Recherch\u00e9 en Elevage pour le D\u00e9veloppement, BP: 433, Farcha, N\u2019Djam\u00e9na, Chad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daugla Doumagoum","family":"Moto","sequence":"additional","affiliation":[{"name":"Centre de Support en Sant\u00e9 International, BP: 972, Moursal, N\u2019Djam\u00e9na, Chad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kemdongarti","family":"Naissengar","sequence":"additional","affiliation":[{"name":"Institut de Recherch\u00e9 en Elevage pour le D\u00e9veloppement, BP: 433, Farcha, N\u2019Djam\u00e9na, Chad"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Zinsstag","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, P.O.Box, Socinstrasse 57, CH-4002 Basel, Switzerland"},{"name":"University of Basel, Petersplatz 1, CH-4051 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,8,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"L\u00e9chenne, M., Miranda, M.E., and Zinsstag, J. (2015). Integrated Rabies Control. One Health: The Theory and Practice of Integrated Health Approaches, CABI.","DOI":"10.1079\/9781780643410.0176"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.antiviral.2013.01.003","article-title":"Current and future approaches to the therapy of human rabies","volume":"99","author":"Jackson","year":"2013","journal-title":"Antivir. Res."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Hampson, K., Coudeville, L., Lembo, T., Sambo, M., Kieffer, A., Attlan, M., Barrat, J., Blanton, J.D., Briggs, D.J., and Cleaveland, S. (2015). Estimating the global burden of endemic canine rabies. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003786"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.medmal.2007.01.010","article-title":"The point on human rabies in Senegal from 1986 to 2005","volume":"37","author":"Diop","year":"2007","journal-title":"Med. Mal. Infect."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.3917\/spub.096.0595","article-title":"Observance du traitement vaccinal antirabique chez les sujets expos\u00e9s \u00e0 la rage \u00e0 Abidjan (C\u00f4te d\u2019Ivoire)","volume":"21","author":"Konan","year":"2010","journal-title":"Sant\u00e9 Publique"},{"key":"ref_6","unstructured":"WHO (2015). Global Elimination of Dog-Mediated Human Rabies\u2014The Time Is Now!, WHO."},{"key":"ref_7","first-page":"304","article-title":"Estimating human rabies mortality in the United Republic of Tanzania from dog bite injuries","volume":"80","author":"Cleaveland","year":"2002","journal-title":"Bull. World Health Organ."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.4269\/ajtmh.16-0785","article-title":"Cost-effectiveness evaluation of a novel integrated bite case management program for the control of human rabies, Haiti 2014\u20132015","volume":"96","author":"Undurraga","year":"2017","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0264-410X(02)00778-8","article-title":"A dog rabies vaccination campaign in rural Africa: Impact on the incidence of dog rabies and human dog-bite injuries","volume":"21","author":"Cleaveland","year":"2003","journal-title":"Vaccine"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.vaccine.2012.05.023","article-title":"Human and animal rabies prevention and control cost in Bhutan, 2001\u20132008: The cost-benefit of dog rabies elimination","volume":"31","author":"Tenzin","year":"2012","journal-title":"Vaccine"},{"key":"ref_11","first-page":"281","article-title":"Economics of human and canine rabies elimination: Guidelines for programme orientation","volume":"68","author":"Bogel","year":"1990","journal-title":"Bull World Health Organ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"14996","DOI":"10.1073\/pnas.0904740106","article-title":"Transmission dynamics and economics of rabies control in dogs and humans in an African city","volume":"106","author":"Zinsstag","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Mindekem, R., L\u00e9chenne, M., Oussiguere, A., Naissengar, K., Kebkiba, B., Salifou, S., Ouedraogo, L., Alfaroukh, I., Daugla, D., and Zinsstag, J. (2017). Cost description and comparative cost-efficiency of Post-Exposure-Prophylaxis and canine mass vaccination against rabies in N\u2019Djamena, Chad. Front. Vet. Sci., 4.","DOI":"10.3389\/fvets.2017.00038"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1017\/S0950268897008601","article-title":"Rabies in Thailand","volume":"120","author":"Mitmoonpitak","year":"1998","journal-title":"Epidemiol. Infect."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.actatropica.2009.06.009","article-title":"Human rabies focusing on dog ecology-A challenge to public health in Sri Lanka","volume":"112","author":"Kumarapeli","year":"2009","journal-title":"Acta Trop."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1863-2378.2009.01306.x","article-title":"Evaluation of mass vaccination campaign coverage against rabies in dogs in Tunisia","volume":"58","author":"Touihri","year":"2011","journal-title":"Zoonoses Public Health"},{"key":"ref_17","first-page":"739","article-title":"Coverage of pilot parenteral vaccination campaign against canine rabies in N\u2019Djam\u00e9na, Chad","volume":"81","author":"Kayali","year":"2003","journal-title":"Bull. World Health Organ."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1017\/S0950268809002386","article-title":"Effectiveness of dog rabies vaccination programmes: comparison of owner-charged and free vaccination campaigns","volume":"137","author":"Mindekem","year":"2009","journal-title":"Epidemiol. Infect."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.vaccine.2015.11.033","article-title":"Operational performance and analysis of two rabies vaccination campaigns in N\u2019Djam\u00e9na, Chad","volume":"34","author":"Lechenne","year":"2016","journal-title":"Vaccine"},{"key":"ref_20","unstructured":"Zinsstag, J.L.M., Laager, M., Mindekem, R., Na\u00efssengar, S., Oussig\u00e9r\u00e9, A., Bidjeh, K., Rives, G., Teissier, J., Madjaninan, S., and Ouagal, M. (2017). Mass dog vaccination rapidly interrupts rabies transmission and human exposure in an African city. Sci. Transl. Med., in press."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Lechenne, M., Naissengar, K., Lepelletier, A., Alfaroukh, I.O., Bourhy, H., Zinsstag, J., and Dacheux, L. (2016). Validation of a rapid rabies diagnostic tool for field surveillance in developing countries. PLoS Negl. Trop. Dis., 10.","DOI":"10.1371\/journal.pntd.0005010"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1111\/tmi.12202","article-title":"Survey of animal bite injuries and their management for an estimate of human rabies deaths in N\u2019Djam\u00e9na, Chad","volume":"18","author":"Frey","year":"2013","journal-title":"Trop. Med. Int. Health"},{"key":"ref_23","unstructured":"WHO (2013). WHO Expert Consultation on Rabies. Second report. World Health Organ. Tech. Rep., 982, 1\u2013139."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"78","DOI":"10.7861\/clinmedicine.14-6-78","article-title":"Rabies: The clinical features, management and prevention of the classic zoonosis","volume":"15","author":"Warrell","year":"2015","journal-title":"Clin. Med."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Mbilo, C., L\u00e9chenne, M., Hattendorf, J., Madjadinan, S., Anyiam, F., and Zinsstag, J. (2016). Rabies awareness and dog ownership among rural northern and southern Chadian communities\u2014Analysis of a community-based, cross-sectional household survey. Acta Trop.","DOI":"10.1016\/j.actatropica.2016.06.003"},{"key":"ref_26","first-page":"53","article-title":"Impact of canine demography on rabies transmission in N'Djam\u00e9na, Chad","volume":"65","author":"Mindekem","year":"2005","journal-title":"Med. Trop."},{"key":"ref_27","unstructured":"Laager, M., Lechenne, M., Naissengar, K., Mindekem, R., Oussiguere, A., Zinsstag, J., and Chitnis, N. (2017). A metapopulation model of dog rabies transmission in N\u2019Djam\u00e9na, Chad. J. Theor. Biol., submitted."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Hampson, K., Dobson, A., Kaare, M., Dushoff, J., Magoto, M., Sindoya, E., and Cleaveland, S. (2008). Rabies exposures, post-exposure prophylaxis and deaths in a region of endemic canine rabies. PLoS Negl. Trop. Dis., 2.","DOI":"10.1371\/journal.pntd.0000339"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Tenzin, D.N.K., Gyeltshen, T., Firestone, S., Zangmo, C., Dema, C., Gyeltshen, R., and Ward, M.P. (2011). Dog bites in humans and estimating human rabies mortality in rabies endemic areas of Bhutan. PLoS Negl. Trop. Dis., 5.","DOI":"10.1371\/journal.pntd.0001391"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.5604\/12321966.1141372","article-title":"Epidemiology of animal bites and other potential rabies exposures and anti-rabies vaccine utilization in a rural area in Southern Ethiopia","volume":"22","author":"Ramos","year":"2015","journal-title":"Ann. Agric. Environ. Med. AAEM"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.vetmic.2006.04.009","article-title":"Canine vaccination--providing broader benefits for disease control","volume":"117","author":"Cleveland","year":"2006","journal-title":"Vet. Microbiol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3201\/eid1706.101962","article-title":"Effect of media warnings on rabies postexposure prophylaxis, France","volume":"17","author":"Gautret","year":"2011","journal-title":"Emerg. Infect. Dis."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sambo, M., Lembo, T., Cleaveland, S., Ferguson, H.M., Sikana, L., Simon, C., Urassa, H., and Hampson, K. (2014). Knowledge, attitudes and practices (KAP) about rabies prevention and control: A community survey in Tanzania. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003310"},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Kabeta, T., Deresa, B., Tigre, W., Ward, M.P., and Mor, S.M. (2015). Knowledge, Attitudes and practices of animal bite victims attending an anti-rabies health center in Jimma Town, Ethiopia. PLoS Negl. Trop. Dis., 9.","DOI":"10.1371\/journal.pntd.0003867"}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/2\/3\/43\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:43:03Z","timestamp":1760208183000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/2\/3\/43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,23]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2017,9]]}},"alternative-id":["tropicalmed2030043"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed2030043","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,23]]}}}