{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:19:20Z","timestamp":1790817560940,"version":"4.1.0"},"reference-count":65,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T00:00:00Z","timestamp":1520812800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Melioidosis is a notifiable infectious disease registered with the Ministry of Health (MOH) and Agri-Food &amp; Veterinary Authority (AVA), Singapore. From a clinical perspective, increased awareness of the disease has led to early detection and treatment initiation, thus resulting in decreasing mortality rates in recent years. However, the disease still poses a threat to local pet, zoo and farm animals, where early diagnosis is a challenge. The lack of routine environmental surveillance studies also makes prevention of the disease in animals difficult. To date, there have been no reports that provide a complete picture of how the disease impacts the local human and animal populations in Singapore. Information on the distribution of Burkholderia pseudomallei in the environment is also lacking. The aim of this review is to provide a comprehensive overview of both published and unpublished clinical, veterinary and environmental studies on melioidosis in Singapore to achieve better awareness and management of the disease.<\/jats:p>","DOI":"10.3390\/tropicalmed3010031","type":"journal-article","created":{"date-parts":[[2018,3,12]],"date-time":"2018-03-12T13:13:48Z","timestamp":1520860428000},"page":"31","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Melioidosis in Singapore: Clinical, Veterinary, and Environmental Perspectives"],"prefix":"10.3390","volume":"3","author":[{"given":"Siew","family":"Sim","sequence":"first","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Ong","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunn","family":"Gan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongling","family":"Wang","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Koh","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yian","family":"Tan","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Wong","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Chew","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sian","family":"Ling","sequence":"additional","affiliation":[{"name":"Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore 117510, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Tan","sequence":"additional","affiliation":[{"name":"Laboratories Group, Agri-Food &amp; 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