{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T00:40:22Z","timestamp":1793839222877,"version":"4.6.1"},"reference-count":47,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T00:00:00Z","timestamp":1529366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2013-CoG 614739-A_HERO"],"award-info":[{"award-number":["ERC-2013-CoG 614739-A_HERO"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Programme d'Appui Strat\u00e9gique \u00e0 la Recherche Scientifique","award":["113"],"award-info":[{"award-number":["113"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Over the past decade, a significant reduction in the prevalence of schistosomiasis has been achieved, partially explained by the large-scale administration of praziquantel. Yet, the burden of schistosomiasis remains considerable, and factors influencing intervention coverage are important. This study aimed to deepen the understanding of low treatment coverage rates observed in two schistosomiasis-endemic villages in C\u00f4te d\u2019Ivoire. The research was conducted in August 2015, in Moronou and Bigouin, two villages of C\u00f4te d\u2019Ivoire that are endemic for Schistosoma haematobium and S. mansoni, respectively. After completion of a clinical trial, standard praziquantel treatment (single 40 mg\/kg oral dose) was offered to all village inhabitants by community health workers using a house-to-house approach. Factors influencing treatment coverage were determined by a questionnaire survey, randomly selecting 405 individuals. The overall treatment coverage rate was only 47.6% (2730\/5733) with considerable intervillage heterogeneity (27.7% in Bigouin (302\/1091) versus 52.3% in Moronou (2428\/4642)). Among the 200 individuals interviewed in Moronou, 50.0% were administered praziquantel, while only 19.5% of the 205 individuals interviewed in Bigouin received praziquantel. The main reasons for low treatment coverage were work-related (agricultural activities), the bitter taste of praziquantel and previous experiences with adverse events. The most suitable period for treatment campaigns was reported to be the dry season. More than three-quarter of the interviewees who had taken praziquantel (overall, 116\/140; Moronou, 84\/100; Bigouin, 32\/40) declared that they would not participate in future treatments (p &lt; 0.001). In order to enhance praziquantel treatment coverage, careful consideration should be given to attitudes and practices, such as prior or perceived adverse events and taste of praziquantel, and appropriate timing, harmonized with agricultural activities. Without such understanding, breaking the transmission of schistosomiasis remains a distant goal.<\/jats:p>","DOI":"10.3390\/tropicalmed3020069","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T11:20:36Z","timestamp":1529407236000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["A Rapid Appraisal of Factors Influencing Praziquantel Treatment Compliance in Two Communities Endemic for Schistosomiasis in C\u00f4te d\u2019Ivoire"],"prefix":"10.3390","volume":"3","author":[{"given":"Jean T.","family":"Coulibaly","sequence":"first","affiliation":[{"name":"Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland"},{"name":"University of Basel, P.O. Box, CH-4001 Basel, Switzerland"},{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, 01 BP 770, Abidjan 01, C\u00f4te d\u2019Ivoire"},{"name":"Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, 01 BP 1303, Abidjan 01, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mamadou","family":"Ouattara","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, 01 BP 770, Abidjan 01, C\u00f4te d\u2019Ivoire"},{"name":"Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, 01 BP 1303, Abidjan 01, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Barda","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland"},{"name":"University of Basel, P.O. Box, CH-4001 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrg","family":"Utzinger","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland"},{"name":"University of Basel, P.O. Box, CH-4001 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli\u00e9zer K.","family":"N\u2019Goran","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Formation et de Recherche Biosciences, Universit\u00e9 F\u00e9lix Houphou\u00ebt-Boigny, 01 BP 770, Abidjan 01, C\u00f4te d\u2019Ivoire"},{"name":"Centre Suisse de Recherches Scientifiques en C\u00f4te d\u2019Ivoire, 01 BP 1303, Abidjan 01, C\u00f4te d\u2019Ivoire"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0290-3521","authenticated-orcid":false,"given":"Jennifer","family":"Keiser","sequence":"additional","affiliation":[{"name":"Swiss Tropical and Public Health Institute, P.O. Box, CH-4002 Basel, Switzerland"},{"name":"University of Basel, P.O. Box, CH-4001 Basel, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1473-3099(06)70521-7","article-title":"Schistosomiasis and water resources development: Systematic review, meta-analysis, and estimates of people at risk","volume":"6","author":"Steinmann","year":"2006","journal-title":"Lancet Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Hotez, P.J., Alvarado, M., Bas\u00e1\u00f1ez, M.G., Bolliger, I., Bourne, R., Boussinesq, M., Brooker, S.J., Brown, A.S., Buckle, G., and Budke, C.M. (2014). The Global Burden of Disease study 2010: Interpretation and implications for the neglected tropical diseases. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0002865"},{"key":"ref_3","unstructured":"GBD 2016 DALYs and HALE Collaborators (2017). 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