{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:43:20Z","timestamp":1788317000045,"version":"build-2803163510"},"reference-count":42,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T00:00:00Z","timestamp":1535155200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Melioidosis, although endemic in many parts of Southeast Asia, has not been systematically studied in Hong Kong, which is a predominantly urban area located in the subtropics. This review describes the early outbreaks of melioidosis in captive animals in Hong Kong in the 1970s, as well as the early reports of human clinical cases in the 1980s. A review of all hospitalized human cases of culture-confirmed melioidosis in the last twenty years showed an increasing trend in the incidence of the disease, with significant mortality observed. The lack of awareness of this disease among local physicians, the delay in laboratory diagnosis and the lack of epidemiological surveillance are among the greatest challenges of managing melioidosis in the territory.<\/jats:p>","DOI":"10.3390\/tropicalmed3030091","type":"journal-article","created":{"date-parts":[[2018,8,27]],"date-time":"2018-08-27T10:56:04Z","timestamp":1535367364000},"page":"91","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Melioidosis in Hong Kong"],"prefix":"10.3390","volume":"3","author":[{"given":"Grace","family":"Lui","sequence":"first","affiliation":[{"name":"Department of Medicine and Therapeutics, Faculty of Medicine, Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Tam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Tso","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics, United Christian Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonpaul","family":"Zee","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology, Tuen Mun Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Alice Ho Miu Ling Nethersole Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Lam","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Chan","sequence":"additional","affiliation":[{"name":"Department of Medicine and Geriatrics, Princess Margaret Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan","family":"Ting","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Elizabeth Hospital, Hong Kong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Medicine, Queen Mary Hospital, Hong Kong, China"},{"name":"Carol Yu Centre for Infection, Department of Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China"},{"name":"Department of Clinical Microbiology and Infection Control, The University of Hong Kong-Shenzhen Hospital, Shenzhen 518172, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,8,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1128\/CMR.18.2.383-416.2005","article-title":"Melioidosis: Epidemiology, pathophysiology, and management","volume":"18","author":"Cheng","year":"2005","journal-title":"Clin. 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