{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:15:53Z","timestamp":1762604153130,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T00:00:00Z","timestamp":1558396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Colombian Science, Technology and Innovation Fund of Sistema General de Regal\u00edas","award":["BPIN 2013000100011"],"award-info":[{"award-number":["BPIN 2013000100011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Dengue is still an important cause of disease and mortality in tropical countries, as is influenza A virus, which is also a cause of epidemics all over the globe. In this article, we present the case of a 31-year-old woman who was in her second trimester of pregnancy and presented with severe dengue with hematological and neurological complications, and premature labor. She was misdiagnosed with bacterial infection and received antibiotic treatment with no improvement of the clinical manifestations and previous to death, she was diagnosed with dengue infection. She died from cardiorespiratory arrest. In the postmortem evaluation, influenza A co-infection was confirmed and characterization of the tissue damage and immune response in lung, liver, kidney, heart, spleen, and brain was determined, finding a severe inflammatory response in lung with T cells and macrophages infiltrating the tissue. This case report highlights the risks of accepting a single diagnosis, especially in endemic countries to multiple tropical diseases, which can lead to delay in appropriate treatment that could reduce morbidity and mortality.<\/jats:p>","DOI":"10.3390\/tropicalmed4020084","type":"journal-article","created":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T10:52:51Z","timestamp":1558435971000},"page":"84","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dengue Virus and Influenza A Virus Co-Infection in Pregnancy: A Case Report"],"prefix":"10.3390","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5515-263X","authenticated-orcid":false,"given":"M\u00f3nica","family":"Guzm\u00e1n-Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Magister in Biomedical Sciences, Universidad del Valle, Cali 760001, Colombia"},{"name":"Emergent Viruses and Disease - VIREM, Universidad del Valle, Cali 760001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9ctor F.","family":"Acosta-\u00d1a\u00f1ez","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universidad del Valle, Cali 760001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio C\u00e9sar","family":"Mantilla","sequence":"additional","affiliation":[{"name":"Department of Pathology, Universidad Industrial de Santander, Bucaramanga 680001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anilza","family":"Bonelo","sequence":"additional","affiliation":[{"name":"Emergent Viruses and Disease - VIREM, Universidad del Valle, Cali 760001, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1038\/s41577-019-0123-x","article-title":"Adaptive immune responses to primary and secondary dengue virus infections","volume":"19","author":"Rathore","year":"2019","journal-title":"Nat. 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