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Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmania and Other Protozoal Infectious. Goodman\u2019s & Gilmans\u2014The Pharmacological Basis of Therapeutics, McGraw Hill Medical. [12th ed.]."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1756-3305-3-15","article-title":"The development of drugs for treatment of sleeping sickness: A historical review","volume":"3","author":"Steverding","year":"2010","journal-title":"Parasites Vectors"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2147\/CLEP.S39728","article-title":"Epidemiology of human African trypanosomiasis","volume":"6","author":"Simarro","year":"2014","journal-title":"Clin. Epidemiol."},{"key":"ref_9","first-page":"437","article-title":"Control of human African trypanosomiasis: Back to square one","volume":"61","author":"Jannin","year":"2001","journal-title":"Med Trop (Mars)."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1136\/bmj.331.7527.1242","article-title":"Sleeping sickness\u2014A growing problem?","volume":"331","author":"Jannin","year":"2005","journal-title":"BMJ"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.1365-3156.2001.00730.x","article-title":"Are there new approaches to roll back trypanosomiasis (Editorial)","volume":"6","author":"Burri","year":"2001","journal-title":"Trop. Med. Int. Health"},{"key":"ref_12","unstructured":"Moran, M., Ropars, A.L., Guzman, J., Diaz, J., and Garrison, C. (2005). The New Landscape of Neglected Disease Drug Development, Wellcome Trust."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1136\/bmj.331.7527.1242","article-title":"Commentary: Sleeping sickness\u2014A growing problem?","volume":"331","author":"Jannin","year":"2005","journal-title":"BMJ"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/01.qco.0000244045.93016.b1","article-title":"New developments in human African trypanosomiasis","volume":"19","author":"Brun","year":"2006","journal-title":"Curr. Opin. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"46","DOI":"10.4269\/ajtmh.1987.36.46","article-title":"Effects of the Ornithine Decarboxylase Inhibitors Dl-\u03b1-Difluoromethylornithine and \u03b1-Monofluoromethyldehydroornithine Methyl Ester Alone and in Combination with Suramin against Trypanosoma brucei brucei Central Nervous System Models","volume":"36","author":"Bacchi","year":"1987","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1586\/14787210.2014.959496","article-title":"Treatment options for second-stage gambiense human African trypanosomiasis","volume":"12","author":"Eperon","year":"2014","journal-title":"Expert Rev. Anti-Infective Ther."},{"key":"ref_17","first-page":"650","article-title":"Nifurtimox in late-stage arsenical refractory gambiense sleeping sickness","volume":"81","author":"Vannieuwenhove","year":"1988","journal-title":"Bull. Soci\u00e9t\u00e9 Pathol. Exot."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0140-6736(00)02141-3","article-title":"Efficacy of new, concise schedule for melarsoprol in treatment of sleeping sickness caused by Trypanosoma brucei gambiense: A randomised trial","volume":"355","author":"Burri","year":"2000","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S0140-6736(04)16940-7","article-title":"Efficacy of 10-day melarsoprol schedule 2 years after treatment for late-stage gambiense sleeping sickness","volume":"364","author":"Schmid","year":"2004","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1086\/429929","article-title":"Effectiveness of a 10-Day Melarsoprol Schedule for the Treatment of Late-Stage Human African Trypanosomiasis: Confirmation from a Multinational Study (I mpamel II)","volume":"191","author":"Schmid","year":"2005","journal-title":"J. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1067\/mcp.2000.105990","article-title":"Investigations of the metabolites of the trypanocidal drug melarsoprol","volume":"67","author":"Keiser","year":"2000","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/S0140-6736(09)61117-X","article-title":"Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: A multicentre, randomised, phase III, non-inferiority trial","volume":"374","author":"Priotto","year":"2009","journal-title":"Lancet"},{"key":"ref_23","unstructured":"WHO (2013). Control and Surveillance of Human African Trypanosomiasis: Report of a WHO Expert Committee, World Health Organisation."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1017\/S0031182012000169","article-title":"Update on field use of the available drugs for the chemotherapy of human African trypanosomiasis","volume":"139","author":"Simarro","year":"2012","journal-title":"Parasitology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1016\/S1473-3099(19)30612-7","article-title":"New WHO guidelines for treatment of gambiense human African trypanosomiasis including fexinidazole: Substantial changes for clinical practice","volume":"20","author":"Lindner","year":"2020","journal-title":"Lancet Infect. Dis."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1080\/21548331.1992.11705350","article-title":"Louise Pearce: A \u2018Magic Bullet\u2019 for African Sleeping Sickness","volume":"27","author":"Bendiner","year":"1992","journal-title":"Hosp. Pr."},{"key":"ref_27","unstructured":"(2019, December 30). Acoziborole\u2014DNDi. Available online: https:\/\/www.dndi.org\/diseases-projects\/portfolio\/acoziborole\/."},{"key":"ref_28","first-page":"169","article-title":"A card-agglutination test with stained trypanosomes (C.A.T.T.) for the serological diagnosis of T. B. gambiense trypanosomiasis","volume":"58","author":"Magnus","year":"1978","journal-title":"Ann. Soc. Belg. Med. Trop."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lejon, V., B\u00fcscher, P., Nzoumbou-Boko, R., Bossard, G., Jamonneau, V., Bucheton, B., Truc, P., Lemesre, J.-L., Solano, P., and Vincendeau, P. (2019). The separation of trypanosomes from blood by anion exchange chromatography: From Sheila Lanham\u2019s discovery 50 years ago to a gold standard for sleeping sickness diagnosis. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007051"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/0035-9203(79)90092-0","article-title":"Trypanosoma brucei: Miniature anion exchange centrifugation for detection of low parasitemias: Adaptation for field use","volume":"73","author":"Lumsden","year":"1979","journal-title":"Trans. Roy. Soc. Trop. Med. Hyg."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e359","DOI":"10.1016\/S2214-109X(14)70203-7","article-title":"Sensitivity and specificity of HAT Sero-K-SeT, a rapid diagnostic test for serodiagnosis of sleeping sickness caused by Trypanosoma brucei gambiense: A case-control study","volume":"2","author":"Mertens","year":"2014","journal-title":"Lancet Glob. Heal."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5517","DOI":"10.1128\/JCM.41.12.5517-5524.2003","article-title":"Loop-Mediated Isothermal Amplification for Detection of African Trypanosomes","volume":"41","author":"Kuboki","year":"2003","journal-title":"J. Clin. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Grab, D.J., Nikolskaia, O.V., Courtioux, B., Thekisoe, O.M.M., Magez, S., Bogorad, M., Dumler, J.S., and Bisser, S. (2019). Using detergent-enhanced LAMP for African trypanosome detection in human cerebrospinal fluid and implications for disease staging. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007631"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1051\/parasite\/2019066","article-title":"Immune trypanolysis test as a promising bioassay to monitor the elimination of gambiense human African trypanosomiasis","volume":"26","author":"Dama","year":"2019","journal-title":"Parasite"},{"key":"ref_35","unstructured":"DiTECT-HAT Consortium (2020, February 16). Diagnostic Tools for Human African Trypanosomiasis Elimination and Clinical Trials (DiTECT-HAT). Available online: https:\/\/www.ditect-hat.eu\/g."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Jamonneau, V., Ilboudo, H., Kabore, J., Kaba, D., Koffi, M., Solano, P., Garcia, A., Courtin, D., Laveissi\u00e8re, C., and Lingue, K. (2012). Untreated Human Infections by Trypanosoma brucei gambiense Are Not 100% Fatal. PLoS Negl. Trop. Dis., 6.","DOI":"10.1371\/journal.pntd.0001691"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"157","DOI":"10.7554\/eLife.17716","article-title":"The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes","volume":"5","author":"Capewell","year":"2016","journal-title":"eLife"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Caljon, G., Van Reet, N., De Trez, C., Vermeersch, M., P\u00e9rez-Morga, D., and Abbeele, J.V.D. (2016). The Dermis as a Delivery Site of Trypanosoma brucei for Tsetse Flies. PLoS Pathog., 12.","DOI":"10.1371\/journal.ppat.1005744"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.pt.2017.11.008","article-title":"Do cryptic reservoirs threaten gambienses-leeping sickness elimination?","volume":"34","author":"Buscher","year":"2018","journal-title":"Trends Parasitol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/bs.apar.2014.12.003","article-title":"Mathematical Models of Human African Trypanosomiasis Epidemiology","volume":"87","author":"Rock","year":"2015","journal-title":"Adv. Parasitol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1016\/S2214-109X(16)30237-6","article-title":"Seeing beyond 2020: An economic evaluation of contemporary and emerging strategies for elimination of Trypanosoma brucei gambiense","volume":"5","author":"Sutherland","year":"2017","journal-title":"Lancet Glob. Heal."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s13071-015-1131-8","article-title":"Quantitative evaluation of the strategy to eliminate human African trypanosomiasis in the Democratic Republic of Congo","volume":"8","author":"Rock","year":"2015","journal-title":"Parasites Vectors"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13071-015-1121-x","article-title":"Evaluating long-term effectiveness of sleeping sickness control measures in Guinea","volume":"8","author":"Pandey","year":"2015","journal-title":"Parasites Vectors"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Ndeffo-Mbah, M.L., Pandey, A., Atkins, K.E., Aksoy, S., and Galvani, A.P. (2019). The impact of vector migration on the effectiveness of strategies to control gambiense human African trypanosomiasis. PLoS Negl. Trop. Dis., 13.","DOI":"10.1371\/journal.pntd.0007903"},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Aksoy, S., B\u00fcscher, P., Lehane, M., Solano, P., and Abbeele, J.V.D. (2017). Human African trypanosomiasis control: Achievements and challenges. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005454"},{"key":"ref_46","unstructured":"(2020, February 16). All Past Events\/Information Related to Human African Trypanosomiasis. Available online: https:\/\/www.who.int\/trypanosomiasis_african\/archives\/en\/."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Franco, J.R., Cecchi, G., Priotto, G., Paone, M., Diarra, A., Grout, L., Simarro, P.P., Zhao, W., and Argaw, D. (2018). Monitoring the elimination of human African trypanosomiasis: Update to 2016. PLoS Negl. Trop. Dis., 12.","DOI":"10.1371\/journal.pntd.0006890"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Mudji, J., Benhamou, J., Mwamba, E., Burri, C., and Blum, J. (2019). The Flipside of Eradicating a Disease; Human African Trypanosomiasis in a Woman in Rural Democratic Republic of Congo: A Case Report. Trop. Med. Infect. Dis., 4.","DOI":"10.3390\/tropicalmed4040142"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Falisse, J.-B., Mwamba, E., and Mpanya, A. (2020). Whose Elimination? Frontline Workers\u2019 Perspectives on the Elimination of the Human African Trypanosomiasis and Its Anticipated Consequences. Trop. Med. Infect. Dis., 5.","DOI":"10.3390\/tropicalmed5010006"},{"key":"ref_50","unstructured":"(2020, February 16). Poverty and Health. 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