{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T12:44:20Z","timestamp":1773837860536,"version":"3.50.1"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T00:00:00Z","timestamp":1600214400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Rickettsia typhi and Bartonella henselae are the causative agents of murine typhus and cat-scratch disease, respectively. A small-scale survey (N = 202) was conducted in the Attica region, Greece, for determining the prevalence rates of IgG antibodies against B. henselae and R. typhi by indirect fluorescence antibody test. IgG against B. henselae and R. typhi were present in 17.8% (36\/202) and 4.5% (9\/202) of the participants, respectively; co-occurring IgG against both B. henselae and R. typhi were detected in 3.5% (7\/202), whereas only anti-B. henselae IgG in 14.3% (29\/202), and only anti-R. typhi IgG in 1.0% (2\/202). Titres 1\/64, 1\/128, 1\/256, and 1\/512, of anti-B. henselae IgG were identified in 6.4%, 4.5%, 4.5%, and 2.4%, whereas titres 1\/40 and 1\/80 of anti-R. typhi IgG were detected in 4.0%, and 0.5%, respectively. A positive association of anti-B. henselae IgG prevalence with a coastal area featuring a major seaport (p = 0.009) and with younger age (p = 0.046) was identified. The findings of this survey raise concern for exposure of the population of Attica to B. henselae and R. typhi, which should be considered in the differential diagnosis when compatible symptoms are present. Our results also suggest that seaports may represent high-risk areas for exposure to Bartonella spp.<\/jats:p>","DOI":"10.3390\/tropicalmed5030145","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T10:30:12Z","timestamp":1600252212000},"page":"145","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Serosurvey of IgG Antibodies against Bartonella henselae and Rickettsia typhi in the Population of Attica, Greece"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4908-6215","authenticated-orcid":false,"given":"Georgios","family":"Dougas","sequence":"first","affiliation":[{"name":"Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Mavrouli","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athanassios","family":"Tsakris","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2209-9772","authenticated-orcid":false,"given":"Charalambos","family":"Billinis","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Veterinary Science, University of Thessaly, 43100 Karditsa, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Papaparaskevas","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1186\/s13071-018-3152-6","article-title":"Bartonella infections in cats and dogs including zoonotic aspects","volume":"11","author":"Breitschwerdt","year":"2018","journal-title":"Parasit Vectors"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.actatropica.2016.10.018","article-title":"Clinical and laboratory characteristics, epidemiology, and outcomes of murine typhus: A systematic review","volume":"166","author":"Tsioutis","year":"2017","journal-title":"Acta Trop"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.3201\/eid1404.071376","article-title":"Murine typhus, Algeria","volume":"14","author":"Mouffok","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.3201\/eid1410.080571","article-title":"Rickettsia typhiand R.felis in Rat Fleas (Xenopsylla cheopis), Oahu, Hawaii","volume":"14","author":"Eremeeva","year":"2008","journal-title":"Emerg Infect. Dis"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1086\/527443","article-title":"Murine Typhus: An Unrecognized Suburban Vectorborne Disease","volume":"46","author":"Civen","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Cheslock, M.A., and Embers, M.E. (2019). Human Bartonellosis: An Underappreciated Public Health Problem?. Trop. Med. Infect. Dis., 4.","DOI":"10.3390\/tropicalmed4020069"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1080\/09273948.2017.1327077","article-title":"Cat Scratch Disease: Not a Benign Condition","volume":"26","author":"Barros","year":"2017","journal-title":"Ocul. Immunol. Inflamm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1089\/vbz.2010.0106","article-title":"Bartonella henselae and the Potential for Arthropod Vector-Borne Transmission","volume":"11","author":"Mosbacher","year":"2011","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cimid.2012.10.004","article-title":"Ctenocephalides felis an in vitro potential vector for five Bartonella species","volume":"36","author":"Bouhsira","year":"2013","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2460\/javma.2004.224.1270","article-title":"Cat scratch disease and other zoonotic Bartonella infections","volume":"224","author":"Chomel","year":"2004","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.vetmic.2014.05.033","article-title":"Experimental infection of cats with Afipia felis and various Bartonella species or subspecies","volume":"172","author":"Chomel","year":"2014","journal-title":"Vet. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1051\/vetres:2007023","article-title":"Canine bartonellosis: Serological and molecular prevalence in Brazil and evidence of co-infection with Bartonella henselae and Bartonella vinsonii subsp.berkhoffii","volume":"38","author":"Diniz","year":"2007","journal-title":"Vet. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"554","DOI":"10.4269\/ajtmh.2003.68.554","article-title":"Occurrence of Bartonella Henselae And Bartonella Quintana In A Healthy Greek Population","volume":"68","author":"Tea","year":"2003","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3904\/kjim.2016.010","article-title":"The seroprevalence of Bartonella henselae in healthy adults in Korea","volume":"32","author":"Kwon","year":"2017","journal-title":"Korean J. Intern. Med."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1007\/s10067-019-04591-5","article-title":"The seroprevalence of Bartonella spp. in the blood of patients with musculoskeletal complaints and blood donors, Poland: A pilot study","volume":"38","author":"Szybka","year":"2019","journal-title":"Clin. Rheumatol"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.cimid.2012.01.002","article-title":"Bartonella and Bartonella infections in China: From the clinic to the laboratory","volume":"35","author":"Liu","year":"2012","journal-title":"Comp. Immunol. Microbiol. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1017\/S0950268808000368","article-title":"Serological evidence of Bartonella henselaeinfection in healthy people in Catalonia, Spain","volume":"136","author":"Pons","year":"2008","journal-title":"Epidemiol. Infect."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.4269\/ajtmh.2002.66.76","article-title":"Prevalence of Rickettsia conorii and Rickettsia typhi infections in the population of northern Greece","volume":"66","author":"Daniel","year":"2002","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e481","DOI":"10.1016\/j.ijid.2011.03.019","article-title":"Seroprevalence of Rickettsia typhi and Rickettsia conorii infections in the Canary Islands","volume":"15","year":"2011","journal-title":"Int. J. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1017\/S0950268816000698","article-title":"Seroprevalence of antibodies to Rickettsia typhi in the Waikato region of New Zealand","volume":"144","author":"Lim","year":"2016","journal-title":"Epidemiol. Infect."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"938","DOI":"10.3201\/eid1406.071502","article-title":"Rickettsial Seroepidemiology among Farm Workers, Tianjin, People\u2019s Republic of China","volume":"14","author":"Zhang","year":"2008","journal-title":"Emerg. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fevo.2019.00088","article-title":"Bartonella Bacteria in Urban Rats: A Movement from the Jungles of Southeast Asia to Metropoles Around the Globe","volume":"7","author":"Kosoy","year":"2019","journal-title":"Front. Ecol. Evol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"7850","DOI":"10.1128\/AEM.06012-11","article-title":"Molecular Detection and Identification of Bartonella Species in Xenopsylla cheopis Fleas (Siphonaptera: Pulicidae) Collected from Rattus norvegicus Rats in Los Angeles, California","volume":"77","author":"Billeter","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.4269\/ajtmh.2006.74.120","article-title":"First Detection of Rickettsia Felis In Ctenocephalides Felis Fleas Parasitizing Rats in Cyprus","volume":"74","author":"Psaroulaki","year":"2006","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1089\/vbz.2014.1606","article-title":"Bartonella infection in rodents and their flea ectoparasites: An overview","volume":"15","author":"Krasnov","year":"2015","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Kuo, C.-C., Wardrop, N., Chang, C.-T., Wang, H.-C., and Atkinson, P.M. (2017). Significance of major international seaports in the distribution of murine typhus in Taiwan. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005589"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ijid.2018.10.024","article-title":"Seroprevalence of spotted fever group and typhus group rickettsiae in individuals with acute febrile illness from Gorakhpur, India","volume":"79","author":"Mane","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1099\/jmm.0.015248-0","article-title":"Evaluation of sensitivity, specificity and cross-reactivity in Bartonella henselae serology","volume":"59","author":"Vermeulen","year":"2010","journal-title":"J. Med. Microbiol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1590\/S0074-02762005000800006","article-title":"Antibodies to Rickettsia rickettsii, Rickettsia typhi, Coxiella burnetii, Bartonella henselae, Bartonella quintana, and Ehrlichia chaffeensis among healthy population in Minas Gerais, Brazil","volume":"100","author":"Costa","year":"2005","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13071-017-2075-y","article-title":"Serological evidence of exposure to Rickettsia felis and Rickettsia typhi in Australian veterinarians","volume":"10","author":"Teoh","year":"2017","journal-title":"Parasit Vectors"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Maina, A.N., Fogarty, C., Krueger, L., Macaluso, K.R., Odhiambo, A., Nguyen, K., Farris, C.M., Luce-Fedrow, A., Bennett, S., and Ju, J.J. (2016). Rickettsial Infections among Ctenocephalides felis and Host Animals during a Flea-Borne Rickettsioses Outbreak in Orange County, California. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0160604"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s13071-016-1534-1","article-title":"Detection of vector-borne pathogens in cats and their ectoparasites in southern Italy","volume":"9","author":"Persichetti","year":"2016","journal-title":"Parasit. Vectors"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1089\/vbz.2010.0008","article-title":"Rickettsia felis in Fleas from Catalonia (Northeast Spain)","volume":"11","author":"Nogueras","year":"2011","journal-title":"Vector Borne Zoonotic Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1128\/JCM.02827-14","article-title":"Bartonella, a Common Cause of Endocarditis: A Report on 106 Cases and Review","volume":"53","author":"Edouard","year":"2014","journal-title":"J. Clin. Microbiol."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/5\/3\/145\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:10:23Z","timestamp":1760177423000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/5\/3\/145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,16]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,9]]}},"alternative-id":["tropicalmed5030145"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed5030145","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,16]]}}}