{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T08:16:42Z","timestamp":1790669802192,"version":"4.1.0"},"reference-count":20,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["206532\/Z\/17\/Z"],"award-info":[{"award-number":["206532\/Z\/17\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DFID-Wellcome Trust","award":["216002\/Z\/19\/Z"],"award-info":[{"award-number":["216002\/Z\/19\/Z"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>This commentary describes the creation of the Zika Virus Individual Participant Data Consortium, a global collaboration to address outstanding questions in Zika virus (ZIKV) epidemiology through conducting an individual participant data meta-analysis (IPD-MA). The aims of the IPD-MA are to (1) estimate the absolute and relative risks of miscarriage, fetal loss, and short- and long-term sequelae of fetal exposure; (2) identify and quantify the relative importance of different sources of heterogeneity (e.g., immune profiles, concurrent flavivirus infection) for the risk of adverse fetal, infant, and child outcomes among infants exposed to ZIKV in utero; and (3) develop and validate a prognostic model for the early identification of high-risk pregnancies and inform communication between health care providers and their patients and public health interventions (e.g., vector control strategies, antenatal care, and family planning programs). By leveraging data from a diversity of populations across the world, the IPD-MA will provide a more precise estimate of the risk of adverse ZIKV-related outcomes within clinically relevant subgroups and a quantitative assessment of the generalizability of these estimates across populations and settings. The ZIKV IPD Consortium effort is indicative of the growing recognition that data sharing is a central component of global health security and outbreak response.<\/jats:p>","DOI":"10.3390\/tropicalmed5040152","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T09:41:01Z","timestamp":1601458861000},"page":"152","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The Zika Virus Individual Participant Data Consortium: A Global Initiative to Estimate the Effects of Exposure to Zika Virus during Pregnancy on Adverse Fetal, Infant, and Child Health Outcomes"],"prefix":"10.3390","volume":"5","author":[{"name":"Zika Virus Individual Participant Data Consortium","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Navarro, J., Arrivillaga-Henr\u00edquez, J., Salazar-Loor, J., and Rodr\u00edguez-Morales, A.J. (2020). COVID-19 and dengue, co-epidemics in Ecuador and other countries in Latin America: Pushing strained health care systems over the edge. Travel Med. Infect. Dis., 101656.","DOI":"10.1016\/j.tmaid.2020.101656"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"101659","DOI":"10.1016\/j.tmaid.2020.101659","article-title":"COVID-19 and dengue fever: A dangerous combination for the health system in Brazil","volume":"35","author":"Lorenz","year":"2020","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_3","unstructured":"Grenadier, A. (2020). The Impact of COVID-19 on Local Vector Control Response, National Association of County and City Health Officials."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1016\/S1473-3099(16)30270-5","article-title":"Potential for Zika virus introduction and transmission in resource-limited countries in Africa and the Asia-Pacific region: A modelling study","volume":"16","author":"Bogoch","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/MOP.0000000000000582","article-title":"Zika clinical updates","volume":"30","author":"Adachi","year":"2018","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1159\/000495660","article-title":"Zika Virus as a Possible Risk Factor for Autism Spectrum Disorder: Neuroimmunological Aspects","volume":"25","author":"Vianna","year":"2019","journal-title":"Neuroimmunomodulation"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e911","DOI":"10.1016\/S2214-109X(16)30255-8","article-title":"Harmonisation of Zika virus research protocols to address key public health concerns","volume":"4","author":"Reveiz","year":"2016","journal-title":"Lancet Glob. Heal."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"c221","DOI":"10.1136\/bmj.c221","article-title":"Meta-analysis of individual participant data: Rationale, conduct, and reporting","volume":"340","author":"Riley","year":"2010","journal-title":"BMJ"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"b375","DOI":"10.1136\/bmj.b375","article-title":"Prognosis and prognostic research: What, why, and how?","volume":"338","author":"Moons","year":"2009","journal-title":"BMJ"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Fernandes, M., Stein, A., Newton, C.R., Cheikh-Ismail, L., Kihara, M., Wulff, K., Quintana, E.D.L., Aranzeta, L., Soria-Frisch, A., and Acedo, J. (2014). The INTERGROWTH-21st Project Neurodevelopment Package: A Novel Method for the Multi-Dimensional Assessment of Neurodevelopment in Pre-School Age Children. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0113360"},{"key":"ref_11","unstructured":"(2019). Cases of Zika Virus Disease by Country or Territory (Weekly Case Report), Pan American Health Organization (PAHO)."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1666566","DOI":"10.1080\/16549716.2019.1666566","article-title":"ZikaPLAN: Addressing the knowledge gaps and working towards a research preparedness network in the Americas","volume":"12","author":"Preet","year":"2019","journal-title":"Glob. Health Action"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s41512-019-0059-4","article-title":"Evidence synthesis in prognosis research","volume":"3","author":"Debray","year":"2019","journal-title":"Diagn. Progn. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.jclinepi.2018.09.001","article-title":"How variation in predictor measurement affects the discriminative ability and transportability of a prediction model","volume":"105","author":"Pajouheshnia","year":"2019","journal-title":"J. Clin. Epidemiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3444","DOI":"10.1002\/sim.8183","article-title":"Impact of predictor measurement heterogeneity across settings on the performance of prediction models: A measurement error perspective","volume":"38","author":"Luijken","year":"2019","journal-title":"Stat. Med."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1478-7954-10-20","article-title":"The influence of measurement error on calibration, discrimination, and overall estimation of a risk prediction model","volume":"10","author":"Rosella","year":"2012","journal-title":"Popul. Health Metrics"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Arias, A.R.L., and Siqueira, C.E. (2018). Women\u2019s lives in times of Zika: Mosquito-controlled lives?. Cad. Sa\u00fade P\u00fablica, 34.","DOI":"10.1590\/0102-311x00178917"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"933","DOI":"10.3201\/eid2405.171479","article-title":"Spontaneous Abortion Associated with Zika Virus Infection and Persistent Viremia","volume":"24","author":"Martinez","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"George, T.L., Harrigan, R.J., Lamanna, J.A., DeSante, D.F., Saracco, J.F., and Smith, T.B. (2015). Persistent impacts of West Nile virus on North American bird populations, National Academy of Sciences.","DOI":"10.1073\/pnas.1507747112"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev.ento.45.1.307","article-title":"CulicoidesBiting Midges: Their Role as Arbovirus Vectors","volume":"45","author":"Mellor","year":"2000","journal-title":"Annu. Rev. \u00c9ntomol."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/5\/4\/152\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:15:06Z","timestamp":1760177706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/5\/4\/152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,30]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["tropicalmed5040152"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed5040152","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,30]]}}}