{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,12]],"date-time":"2026-04-12T07:57:21Z","timestamp":1775980641923,"version":"3.50.1"},"reference-count":40,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"publisher","award":["NU2G GH001152"],"award-info":[{"award-number":["NU2G GH001152"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Background: Identifying infants with congenital infection for early intervention will likely be challenging in future Zika virus outbreaks. We investigated indicators of risk for developmental delay among children born with and without obvious manifestations of congenital Zika virus infection. Methods: We evaluated 120 children conceived during the 2015\u22122016 Zika virus outbreak in Para\u00edba, Brazil. We analyzed data from children at birth; ages 1\u22127 months and approximately 24 months, using medical records (i.e., anthropometric measurements diagnoses), medical evaluation (i.e., Zika\/other laboratory tests, dysmorphic features), and parent report (seizures, developmental delay). We used a Bayesian modeling approach to identify predictors of developmental delay. Results: Head circumference (HC) and length at birth and rates of growth for HC and length at follow-up were consistent across domains of developmental delay; (e.g., for every 1 cm per month decrease in HC growth rate; there was a corresponding decrease in the gross motor z-score). Modeling results indicated that HC and length at birth, and follow-up HC and length rates of growth, were predictive of developmental delay. Conclusion: These findings suggest that accurate measurement and frequent monitoring of HC and length, especially in the first few months of life, may be useful for identifying children possibly congenitally exposed to Zika virus who could benefit from early intervention services.<\/jats:p>","DOI":"10.3390\/tropicalmed5040155","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T09:04:12Z","timestamp":1601543052000},"page":"155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Early Growth Parameters as Predictors of Developmental Delay among Children Conceived During the 2015\u20132016 Zika Virus Outbreak in Northeastern Brazil"],"prefix":"10.3390","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2359-8060","authenticated-orcid":false,"given":"Charles E.","family":"Rose","sequence":"first","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanne","family":"Bertolli","sequence":"additional","affiliation":[{"name":"Division of Human Development and Disability, CDC, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob Elijah","family":"Attell","sequence":"additional","affiliation":[{"name":"Eagle Global Scientific, SanAntonio, TX 78248-4534, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cynthia A.","family":"Moore","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention (CDC), Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2194-9680","authenticated-orcid":false,"given":"Flavio","family":"Melo","sequence":"additional","affiliation":[{"name":"Hospital Regional de Guarabira\/Governo do Estado da Para\u00edba, Jo\u00e3o Pessoa, Para\u00edba 58225-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim","family":"Kotzky","sequence":"additional","affiliation":[{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, TN 37830-8007, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nevin","family":"Krishna","sequence":"additional","affiliation":[{"name":"Center for Preparedness and Response, CDC, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley","family":"Satterfield-Nash","sequence":"additional","affiliation":[{"name":"Oak Ridge Institute for Science and Education, Oak Ridge, TN 37830-8007, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6669-5082","authenticated-orcid":false,"given":"Isabela Ornelas","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Chronic Conditions and Sexually Transmitted Infections (DCCI), Ministry of Health of Brazil, Brasilia 70719-040, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre","family":"Pessoa","sequence":"additional","affiliation":[{"name":"Pediatrics Department of Ceara State Universitiy\u2014UECE, Fortaleza, Cear\u00e1 60714-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna Camille","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Congenital and Developmental Disorders, CDC, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Faria e Silva","family":"Santelli","sequence":"additional","affiliation":[{"name":"Division of Global HIV and TB, Center for Global Health, CDC, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgina","family":"Peacock","sequence":"additional","affiliation":[{"name":"Division of Human Development and Disability, CDC, Atlanta, GA 30329-4027, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Althouse, B.M., Vasilakis, N., Sall, A.A., Diallo, M., Weaver, S.C., and Hanley, K.A. 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