{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T12:17:26Z","timestamp":1793881046837,"version":"4.7.0"},"reference-count":36,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Severe malaria in adults is not well-studied in Sahelian Africa. Clinical features and mortality associated with severe Plasmodium falciparum malaria in adult patients hospitalized in Kiffa, southern Mauritania, were analysed. Patients over 15 years old admitted for severe malaria between August 2016 and December 2019 were included in the present retrospective study. The World Health Organization (WHO) criteria were used to define severe malaria. The presenting clinical characteristics and outcome were compared. Of 4266 patients hospitalized during the study period, 573 (13.4%) had a positive rapid diagnostic test for malaria, and 99 (17.3%; mean age, 37.5 years; range 15\u201379 years; sex-ratio M\/F, 2.1) satisfied the criteria for severe malaria. On admission, the following signs and symptoms were observed in more than one-fourth of the patients: fever (98%), impairment of consciousness (81.8%), multiple convulsions (70.7%), cardiovascular collapse (61.6%), respiratory distress (43.4%), severe anaemia \u2264 80 g\/L (36.4%), haemoglobinuria (27.3%), and renal failure (25.3%). Patients were treated with parenteral quinine or artemether. Fourteen (14.1%) patients died. Multiple convulsions, respiratory distress, severe anaemia, haemoglobinuria, acute renal failure, jaundice, and abnormal bleeding occurred more frequently (p &lt; 0.05) in deceased patients. Mortality due to severe falciparum malaria is high among adults in southern Mauritania. An adoption of the WHO-recommended first-line treatment for severe malaria, such as parenteral artesunate, is required to lower the mortality rate associated with severe malaria.<\/jats:p>","DOI":"10.3390\/tropicalmed6010001","type":"journal-article","created":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T20:39:29Z","timestamp":1608669569000},"page":"1","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical Features and Mortality Associated with Severe Malaria in Adults in Southern Mauritania"],"prefix":"10.3390","volume":"6","author":[{"given":"Boushab Mohamed","family":"Boushab","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Infectious Diseases, Kiffa Regional Hospital, Assaba, Mauritania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Salem","family":"Ould Ahmedou Salem","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche G\u00e9nomes et Milieux, Facult\u00e9 des Sciences et Techniques, Universit\u00e9 de Nouakchott Al-Aasriya, Nouveau Campus Universitaire, BP 5026, Nouakchott, Mauritania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-2776","authenticated-orcid":false,"given":"Ali","family":"Ould Mohamed Salem Boukhary","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Recherche G\u00e9nomes et Milieux, Facult\u00e9 des Sciences et Techniques, Universit\u00e9 de Nouakchott Al-Aasriya, Nouveau Campus Universitaire, BP 5026, Nouakchott, Mauritania"},{"name":"Institut de Recherche pour le D\u00e9veloppement (IRD), Aix-Marseille Universit\u00e9, IRD, AP-HM, SSA, VITROME, 13005 Marseille, France"},{"name":"Institut Hospitalo-Universitaire (IHU)-M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Parola","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement (IRD), Aix-Marseille Universit\u00e9, IRD, AP-HM, SSA, VITROME, 13005 Marseille, France"},{"name":"Institut Hospitalo-Universitaire (IHU)-M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8812-8185","authenticated-orcid":false,"given":"Leonardo","family":"Basco","sequence":"additional","affiliation":[{"name":"Institut de Recherche pour le D\u00e9veloppement (IRD), Aix-Marseille Universit\u00e9, IRD, AP-HM, SSA, VITROME, 13005 Marseille, France"},{"name":"Institut Hospitalo-Universitaire (IHU)-M\u00e9diterran\u00e9e Infection, 13005 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actatropica.2015.08.005","article-title":"Malaria-associated morbidity during the rainy season in Saharan and Sahelian zones in Mauritania","volume":"152","author":"Basco","year":"2015","journal-title":"Acta Trop."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1186\/1475-2875-13-496","article-title":"Efficacy of artesunate-amodiaquine for the treatment of acute uncomplicated falciparum malaria in southern Mauritania","volume":"13","author":"Ouldabdallahi","year":"2014","journal-title":"Malar. 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