{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:16:58Z","timestamp":1790918218831,"version":"4.1.0"},"reference-count":84,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,8]],"date-time":"2021-01-08T00:00:00Z","timestamp":1610064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["RIA2018CO-2514"],"award-info":[{"award-number":["RIA2018CO-2514"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Diabetes Mellitus increases the risk of developing Tuberculosis (TB) disease by about three times; it also doubles the risk of death during TB treatment and other poor TB treatment outcomes. Diabetes may increase the risk of latent infection with Mycobacterium tuberculosis (LTBI), but the magnitude of this effect is less clear. Whilst this syndemic has received considerable attention, most of the published research has focussed on screening for undiagnosed diabetes in TB patients or observational follow-up of TB treatment outcomes by diabetes status. There are thus substantial research and policy gaps, particularly with regard to prevention of TB disease in people with diabetes and management of patients with TB\u2013diabetes, both during TB treatment and after successful completion of TB treatment, when they likely remain at high risk of TB recurrence, mortality from TB and cardiovascular disease. Potential strategies to prevent development of TB disease might include targeted vaccination programmes, screening for LTBI and preventive therapy among diabetes patients or, perhaps ideally, improved diabetes management and prevention. The cost-effectiveness of each of these, and in particular how each strategy might compare with targeted TB prevention among other population groups at higher risk of developing TB disease, is also unknown. Despite research gaps, clinicians urgently need practical management advice and more research evidence on the choice and dose of different anti-diabetes medication and effective medical therapies to reduce cardiovascular risks (statins, anti-hypertensives and aspirin). Substantial health system strengthening and integration may be needed to prevent these at risk patients being lost to care at the end of TB treatment.<\/jats:p>","DOI":"10.3390\/tropicalmed6010008","type":"journal-article","created":{"date-parts":[[2021,1,10]],"date-time":"2021-01-10T23:03:42Z","timestamp":1610319822000},"page":"8","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["The Interaction of Diabetes and Tuberculosis: Translating Research to Policy and Practice"],"prefix":"10.3390","volume":"6","author":[{"given":"Reinout","family":"van Crevel","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, 6500HB Nijmegen, The Netherlands"},{"name":"Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford OX3 7LG, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A.","family":"Critchley","sequence":"additional","affiliation":[{"name":"Population Health Research Institute, St George\u2019s, University of London, London SW17 ORE, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,8]]},"reference":[{"key":"ref_1","first-page":"210","article-title":"Diabetic Coma and Pulmonary Tuberculosis","volume":"50","author":"Root","year":"1934","journal-title":"Trans. Am. Clin. Clim. Assoc."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0140-6736(54)91583-4","article-title":"Tuberculous diabetics: The Birmingham Regional Service","volume":"266","author":"Luntz","year":"1954","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.2337\/dc11-0442","article-title":"Globalization of Diabetes: The role of diet, lifestyle, and genes","volume":"34","author":"Hu","year":"2011","journal-title":"Diabetes Care"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/0962-8479(95)90529-4","article-title":"Incidence of pulmonary tuberculosis among diabetics","volume":"76","author":"Kim","year":"1995","journal-title":"Tuber. Lung Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2105\/AJPH.87.4.574","article-title":"The role of diabetes mellitus in the higher prevalence of tuberculosis among His-panics","volume":"87","author":"Blustein","year":"1997","journal-title":"Am. J. Public Health"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1177\/1742395307081502","article-title":"Diabetes and the risk of tuberculosis: A neglected threat to public health?","volume":"3","author":"Stevenson","year":"2007","journal-title":"Chronic Illn."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Jeon, C.Y., and Murray, M.B. (2008). Diabetes mellitus increases the risk of active tuberculosis: A systematic review of 13 observational studies. PLoS Med., 5.","DOI":"10.1371\/journal.pmed.0050181"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S2213-8587(15)00461-1","article-title":"Diabetes and tuberculosis co-epidemic: The Bali Declaration","volume":"4","author":"Kapur","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S2213-8587(14)70011-7","article-title":"TANDEM: Understanding diabetes and tuberculosis","volume":"2","author":"Dockrell","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"771","DOI":"10.5588\/ijtld.19.0119","article-title":"Tackling diabetes mellitus and tuberculosis: A new Union guide on the management of diabetes-tuberculosis","volume":"23","author":"Lin","year":"2019","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pr."},{"key":"ref_12","first-page":"457","article-title":"The global diabetes epidemic: What does it mean for infectious diseases in tropical countries?","volume":"5","author":"Moore","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S2213-8587(15)00379-4","article-title":"Diabetes and infection: Assessing the association with glycaemic control in population-based studies","volume":"4","author":"Blundell","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S2213-8587(20)30272-2","article-title":"Associations of type 1 and type 2 diabetes with COVID-19-related mortality in England: A whole-population study","volume":"8","author":"Barron","year":"2020","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2337\/dc17-2131","article-title":"Risk of Infection in Type 1 and Type 2 Diabetes Compared With the General Population: A Matched Cohort Study","volume":"41","author":"Carey","year":"2018","journal-title":"Diabetes Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.5588\/ijtld.14.0932","article-title":"Diabetes-related tuberculosis in Denmark: Effect of ethnicity, diabetes duration and year of diagnosis","volume":"19","author":"Carstensen","year":"2015","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"8494","DOI":"10.1038\/s41598-019-44916-7","article-title":"Analytical Exploration of Potential Pathways by which Diabetes Mellitus Impacts Tuberculosis Epidemiology","volume":"9","author":"Awad","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_18","first-page":"719","article-title":"Diabetes Mellitus and Latent Tuberculosis Infection: A Systematic Review and Metaa-nalysis","volume":"64","author":"Lee","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"e029948","DOI":"10.1136\/bmjopen-2019-029948","article-title":"Effect of diabetes mellitus on risk of latent TB infection in a high TB incidence area: A community-based study in Taiwan","volume":"9","author":"Lin","year":"2019","journal-title":"BMJ Open"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"71","DOI":"10.5588\/ijtld.15.0457","article-title":"Increased risk of latent tuberculous infection among persons with pre-diabetes and diabetes mellitus","volume":"20","author":"Hensel","year":"2016","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1001\/jama.2017.7596","article-title":"Prevalence and Ethnic Pattern of Diabetes and Prediabetes in China in 2013","volume":"317","author":"Wang","year":"2017","journal-title":"JAMA"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S2213-8587(17)30174-2","article-title":"Prevalence of diabetes and prediabetes in 15 states of India: Results from the ICMR\u2013INDIAB population-based cross-sectional study","volume":"5","author":"Anjana","year":"2017","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.5588\/ijtld.17.0474","article-title":"Prevalence of dysglycemia and clinical presentation of pulmonary tuberculosis in Western India","volume":"21","author":"Mave","year":"2017","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Al-Rifai, R.H., Pearson, F., Critchley, J.A., and Abu-Raddad, L.J. (2017). Association between diabetes mellitus and active tuberculosis: A sys-tematic review and meta-analysis. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0187967"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/S2213-8587(14)70110-X","article-title":"Clinical management of concurrent diabetes and tuberculosis and the implications for patient services","volume":"2","author":"Riza","year":"2014","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1128\/microbiolspec.TNMI7-0028-2016","article-title":"Tuberculosis Associated with HIV Infection","volume":"5","author":"Tornheim","year":"2017","journal-title":"Microbiol. Spectr."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"783","DOI":"10.5588\/ijtld.18.0433","article-title":"The effects of diabetes on tuberculosis treatment outcomes: An updated systematic review and meta-analysis","volume":"23","author":"Huangfu","year":"2019","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1017\/S0950268817000279","article-title":"Tuberculosis and risk of acute myocardial infarction: A propensity score-matched analysis","volume":"145","author":"Huaman","year":"2017","journal-title":"Epidemiology Infect."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"79","DOI":"10.5588\/ijtld.13.0288","article-title":"Tuberculosis increases the subsequent risk of acute coronary syndrome: A nationwide population-based cohort study","volume":"18","author":"Chung","year":"2014","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1161\/STROKEAHA.109.567735","article-title":"Tuberculosis and the risk of ischemic stroke: A 3-year follow-up study","volume":"41","author":"Sheu","year":"2010","journal-title":"Stroke"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/tmi.12120","article-title":"Diabetes is a strong predictor of mortality during tuberculosis treatment: A prospective cohort study among tuberculosis patients from Mwanza, Tanzania","volume":"18","author":"Range","year":"2013","journal-title":"Trop. Med. Int. Health"},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Reed, G.W., Choi, H., Lee, S.Y., Lee, M., Kim, Y., Park, H., Lee, J., Zhan, X., Kang, H., and Hwang, S. (2013). Impact of Diabetes and Smoking on Mortality in Tuberculosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0058044"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijid.2019.05.015","article-title":"Post-tuberculosis incidence of diabetes, myocardial infarction, and stroke: Ret-rospective cohort analysis of patients formerly treated for tuberculosis in Taiwan, 2002\u20132013","volume":"84","author":"Salindri","year":"2019","journal-title":"Int. J. Infect. Dis."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1093\/cid\/cix910","article-title":"The Relationship Between Latent Tuberculosis Infection and Acute Myocardial Infarction","volume":"66","author":"Huaman","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.5588\/ijtld.18.0045","article-title":"Convergence of non-communicable diseases and tuberculosis: A two-way street?","volume":"22","author":"Magee","year":"2018","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5588\/ijtld.18.0359","article-title":"Point of care HbA1c level for diabetes mellitus management and its accuracy among tuberculosis patients: A study in four countries","volume":"23","author":"Huangfu","year":"2019","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Shewade, H.D., Jeyashree, K., Mahajan, P., Shah, A.N., Kirubakaran, R., Rao, R., and Kumar, A.M.V. (2017). Effect of glycemic control and type of diabetes treatment on unsuccessful TB treatment outcomes among people with TB-Diabetes: A systematic review. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0186697"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1111\/tmi.12198","article-title":"Diabetes mellitus and tuberculosis: Pattern of tuberculosis, two-month smear conversion and treatment outcomes in Guangzhou, China","volume":"18","author":"Mi","year":"2013","journal-title":"Trop. Med. Int. Health"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Nandakumar, K.V., Duraisamy, K., Balakrishnan, S., Sunilkumar, M., Sagili, K.D., Satyanarayana, S., Kumar, A.M.V., and Enarson, D.A. (2013). Outcome of tuberculosis treatment in patients with diabetes mellitus treated in the revised national tuberculosis control programme in Malappuram District, Kerala, India. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0076275"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"e404","DOI":"10.1016\/j.ijid.2012.12.029","article-title":"Clinical characteristics, drug resistance, and treatment outcomes among tuberculosis patients with diabetes in Peru","volume":"17","author":"Magee","year":"2013","journal-title":"Int. J. Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Bai, K.-J., Lee, J.-J., Chien, S.-T., Suk, C.-W., and Chiang, C.-Y. (2016). The Influence of Smoking on Pulmonary Tuberculosis in Diabetic and Non-Diabetic Patients. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0156677"},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Wagnew, F., Eshetie, S., Alebel, A., Dessie, G., Leshargie, C.T., and Abajobir, A.A. (2018). Meta-analysis of the prevalence of tuberculosis in diabetic patients and its association with cigarette smoking in African and Asian countries. BMC Res. Notes, 11.","DOI":"10.1186\/s13104-018-3390-x"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"3","DOI":"10.5588\/pha.18.0048","article-title":"Tuberculosis-diabetes screening: How well are we doing? A mixed-methods study from North India","volume":"9","author":"Majumdar","year":"2019","journal-title":"Public Health Action"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"738","DOI":"10.2471\/BLT.17.206227","article-title":"Accuracy of diabetes screening methods used for people with tuberculosis, Indonesia, Peru, Romania, South Africa","volume":"96","author":"Grint","year":"2018","journal-title":"Bull. World Health Organ."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.diabres.2018.01.018","article-title":"The prevalence and determinants of active tuberculosis among diabetes patients in Cape Town, South Africa, a high HIV\/TB burden setting","volume":"138","author":"Berkowitz","year":"2018","journal-title":"Diabetes Res. Clin. Pr."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/tropicalmed5010019","article-title":"Gaps in Implementing Bidirectional Screening for Tuberculosis and Diabetes Mellitus in Myanmar: An Operational Research Study","volume":"5","author":"Soe","year":"2020","journal-title":"Trop Med. Infect. Dis."},{"key":"ref_47","first-page":"e152","article-title":"Screening diabetes mellitus patients for pulmonary tuberculosis: A multisite study in Indonesia, Peru, Romania and South Africa","volume":"5","author":"Alisjahbana","year":"2020","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Mave, V., Nimkar, S., Prasad, H., Kadam, D., Meshram, S., Lokhande, R., Gupte, N., Jain, D., Gupta, A., and Golub, J.E. (2017). Tuberculosis screening among persons with diabetes mellitus in Pune, India. BMC Infect. Dis., 17.","DOI":"10.1186\/s12879-017-2483-9"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"992","DOI":"10.5588\/ijtld.16.0340","article-title":"Screening for active tuberculosis in a diabetes mellitus clinic in Soweto, South Africa","volume":"20","author":"Majumder","year":"2016","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ijid.2020.01.019","article-title":"Screening for pulmonary tuberculosis in high-risk groups of diabetic patients","volume":"93","author":"Ji","year":"2020","journal-title":"Int. J. Infect. Dis."},{"key":"ref_51","first-page":"1","article-title":"Diabetes mellitus and the risk of multidrug resistant tuberculosis: A meta-analysis","volume":"7","author":"Liu","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"390","DOI":"10.7883\/yoken.JJID.2009.390","article-title":"Tuberculosis complicated by diabetes mellitus at shanghai pulmonary hospital, china","volume":"62","author":"Zhang","year":"2009","journal-title":"Jpn. J. Infect. Dis."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1378\/chest.14-0918","article-title":"Optimal duration of anti-TB treatment in patients with diabetes: Nine or six months?","volume":"147","author":"Wang","year":"2015","journal-title":"Chest"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1086\/507543","article-title":"Exposure to Rifampicin Is Strongly Reduced in Patients with Tuberculosis and Type 2 Diabetes","volume":"43","author":"Nijland","year":"2006","journal-title":"Clin. Infect. Dis."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00228-016-2132-z","article-title":"Anti-tuberculosis drug concentrations in tuberculosis patients with and without diabetes mellitus","volume":"73","author":"Kumar","year":"2016","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1128\/AAC.00447-09","article-title":"Pharmacokinetics of Antituberculosis Drugs in Pulmonary Tuberculosis Patients with Type 2 Diabetes","volume":"54","author":"Ruslami","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12879-017-2226-y","article-title":"Early interventions for diabetes related tuberculosis associate with hastened sputum microbiological clearance in Virginia, USA","volume":"17","author":"Alkabab","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1901891","DOI":"10.1183\/13993003.01891-2019","article-title":"Diabetes is associated with genotypically drug-resistant tuberculosis","volume":"55","author":"Ruesen","year":"2020","journal-title":"Eur. Respir. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.chest.2017.02.032","article-title":"Defining a Research Agenda to Address the Converging Epidemics of Tuber-culosis and Diabetes: Part 2: Underlying Biologic Mechanisms","volume":"152","author":"Ronacher","year":"2017","journal-title":"Chest"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Maganga, E., Smart, L.R., Kalluvya, S., Kataraihya, J.B., Saleh, A.M., Obeid, L., Downs, J.A., Fitzgerald, D.W., and Peck, R.N. (2015). Glucose Metabolism Disorders, HIV and Antiretroviral Therapy among Tanzanian Adults. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0134410"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.2147\/DMSO.S80084","article-title":"Diabetes mellitus and risk factors in human immunodeficiency virus-infected in-dividuals at Jimma University Specialized Hospital, Southwest Ethiopia","volume":"8","author":"Mohammed","year":"2015","journal-title":"Diabetes Metab. Syndr. Obes."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12981-015-0065-8","article-title":"Changes in blood pressure, glucose levels, insulin secretion and anthropometry after long term exposure to antiretroviral therapy in South African women","volume":"12","author":"Abrahams","year":"2015","journal-title":"AIDS Res. Ther."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/S2213-8587(15)00363-0","article-title":"The prevalence of type 2 diabetes among older people in Africa: A systematic review","volume":"4","author":"Werfalli","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_64","first-page":"56","article-title":"Diabetes mellitus among pulmonary tuberculosis patients from four TB-endemic countries: The TANDEM study","volume":"2","author":"Alisjahbana","year":"2019","journal-title":"Clin. Infect. Dis."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.2337\/dci17-0007","article-title":"Response to Comment on American Diabetes Association. Standards of Medical Care in Diabetes-2017. Diabetes Care 2017;40(Suppl. 1):S1-S135","volume":"40","author":"Herman","year":"2017","journal-title":"Diabetes Care"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"569","DOI":"10.7326\/M17-0939","article-title":"Hemoglobin A 1cTargets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians","volume":"168","author":"Qaseem","year":"2018","journal-title":"Ann. Intern. Med."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1056\/NEJMoa0806470","article-title":"10-Year Follow-up of Intensive Glucose Control in Type 2 Diabetes","volume":"359","author":"Holman","year":"2008","journal-title":"New Engl. J. Med."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1093\/infdis\/jiv568","article-title":"Transient Hyperglycemia in Patients With Tuberculosis in Tanzania: Impli-cations for Diabetes Screening Algorithms","volume":"213","author":"Ramaiya","year":"2016","journal-title":"J. Infect. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1086\/519841","article-title":"The effect of type 2 diabetes mellitus on the presentation and treatment re-sponse of pulmonary tuberculosis","volume":"45","author":"Alisjahbana","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/cpt.1232","article-title":"Rifampicin Alters Metformin Plasma Exposure but Not Blood Glucose Levels in Diabetic Tuberculosis Patients","volume":"105","author":"Yunivita","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"263ra159","DOI":"10.1126\/scitranslmed.3009885","article-title":"Metformin as adjunct antituberculosis therapy","volume":"6","author":"Singhal","year":"2014","journal-title":"Sci. Transl. Med."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1093\/cid\/cix819","article-title":"Metformin Use Reverses the Increased Mortality Associated With Diabetes Mellitus During Tuberculosis Treatment","volume":"66","author":"Degner","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1001\/jama.2014.15298","article-title":"Metformin in patients with type 2 diabetes and kidney disease: A systematic review","volume":"312","author":"Inzucchi","year":"2014","journal-title":"JAMA"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1111\/j.1365-3156.2010.02625.x","article-title":"Implications of the global increase of diabetes for tuberculosis control and patient care","volume":"15","author":"Ruslami","year":"2010","journal-title":"Trop. Med. Int. Health"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S2213-8587(15)00521-5","article-title":"Constraints and challenges in access to insulin: A global perspective","volume":"4","author":"Beran","year":"2016","journal-title":"Lancet Diabetes Endocrinol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7861\/clinmedicine.13-1-27","article-title":"Management of diabetes in resource-poor settings","volume":"13","author":"Grant","year":"2013","journal-title":"Clin. Med."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1111\/j.1365-3156.2011.02808.x","article-title":"Applying lessons learnt from the \u2018DOTS\u2019 Tuberculosis Model to monitoring and evaluating persons with diabetes mellitus in Blantyre, Malawi","volume":"16","author":"Allain","year":"2011","journal-title":"Trop. Med. Int. 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