{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T02:41:15Z","timestamp":1760236875495,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,31]],"date-time":"2021-12-31T00:00:00Z","timestamp":1640908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Managing substantial proximal and\/or distal femoral bone defects is one of the biggest challenges in chronic hip periprosthetic joint infection. Most authors use two-stage arthroplasty with a temporary antibiotic-loaded cement spacer for the management of these patients. In this study, we show our experience with one-stage exchange arthroplasty in managing severe bone defects due to radiological-extensive proximal femoral osteomyelitis. Two patients were included in the study. They showed radiological-extensive proximal femoral osteomyelitis, and they were treated with one-stage exchange arthroplasty using megaprosthesis. Diffuse osteomyelitis was confirmed in both cases; in one case, the histology was compatible with osteomyelitis, and the other case had a positive culture identified in a bone sample. At a minimum of a four-year follow-up, the patients did not reveal any clinical, radiological or laboratory signs of infection. In conclusion, one-stage exchange arthroplasty and megaprosthesis is an option for the treatment of chronic hip periprosthetic joint infection associated with radiological-diffuse proximal femoral osteomyelitis.<\/jats:p>","DOI":"10.3390\/tropicalmed7010005","type":"journal-article","created":{"date-parts":[[2022,1,9]],"date-time":"2022-01-09T23:35:09Z","timestamp":1641771309000},"page":"5","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["One-Stage Hip Revision Arthroplasty Using Megaprosthesis in Severe Bone Loss of The Proximal Femur Due to Radiological Diffuse Osteomyelitis"],"prefix":"10.3390","volume":"7","author":[{"given":"Roy","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Traumatology and Orthopedic Surgery, Hospital San Juan de Dios, San Jos\u00e9 10102, Costa Rica"},{"name":"Department of Traumatology and Orthopaedic Surgery, Hospital Cl\u00ednic de Barcelona, University of Barcelona, Carrer Villarroel, 170, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Mu\u00f1oz-Mahamud","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopaedic Surgery, Hospital Cl\u00ednic de Barcelona, University of Barcelona, Carrer Villarroel, 170, 08036 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4790-1423","authenticated-orcid":false,"given":"Guillem","family":"Bori","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Orthopaedic Surgery, Hospital Cl\u00ednic de Barcelona, University of Barcelona, Carrer Villarroel, 170, 08036 Barcelona, Spain"},{"name":"Insitut d\u2019Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS), Carrer Rossell\u00f3, 149, 08036 Barcelona, Spain"},{"name":"Traumatology and Orthopaedic Surgery, University of Vic-Central University of Catalonia (UVic-UCC), 08500 Vic, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1302\/0301-620X.98B11.BJJ-2016-0244.R1","article-title":"Five-year outcome of proximal femoral endoprosthetic arthroplasty for non-tumour indications","volume":"98-B","author":"Grammatopoulos","year":"2016","journal-title":"Bone Jt. 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