{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T17:20:27Z","timestamp":1784308827569,"version":"3.55.0"},"reference-count":34,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Ireland is a country with a low incidence of tuberculosis (TB) (5.6 cases per 100,000 population in 2019) that should be aiming for TB elimination (fewer than 1 case per million of population). To achieve TB elimination in low-incidence countries, programmatic latent tuberculosis infection (LTBI) management is important. This requires high-quality latent tuberculosis infection (LTBI) screening. Aim: To assess the quality of LTBI screening in a tertiary centre in Ireland using a framework. Methods: A retrospective review of the health care records of patients screened for TB in a tertiary centre in Ireland using an interferon-gamma release assay (IGRA) between 2016 and 2018 was performed. Three domains from the Institute of Medicine framework for health care quality, effectiveness, efficiency, and equity, were applied to measure the quality of LTBI screening. Results: Forty patients had LTBI and an indication for treatment, of whom 20% (8\/40) were not offered treatment by the health care provider, 2.5% (1\/40) did not accept treatment, and 10% (4\/40) did not complete treatment. Seventy-five percent (6\/8) of patients not offered treatment were non-Irish. The cost of screening per LTBI case identified was EUR 2048. Conclusions: This study evaluated the quality of LTBI screening using a framework and identified that LTBI screening in this tertiary centre needs to be scaled and expanded, and that treatment initiation needs to be improved, particularly among non-Irish nationals.<\/jats:p>","DOI":"10.3390\/tropicalmed7020019","type":"journal-article","created":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T01:43:27Z","timestamp":1643420607000},"page":"19","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluating the Quality of Latent Tuberculosis Infection Screening in Ireland: A Single-Centre Retrospective Cohort Study"],"prefix":"10.3390","volume":"7","author":[{"given":"James","family":"O\u2019Connell","sequence":"first","affiliation":[{"name":"Department of International Health and Tropical Medicine, Royal College of Surgeons in Ireland, D02 DH60 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Oguntuase","sequence":"additional","affiliation":[{"name":"School of Postgraduate Studies, Royal College of Surgeons in Ireland, D02 YN77 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine, Royal College of Surgeons in Ireland, D09 YD60 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cora","family":"McNally","sequence":"additional","affiliation":[{"name":"Department of International Health and Tropical Medicine, Royal College of Surgeons in Ireland, D02 DH60 Dublin, Ireland"},{"name":"Department of Infectious Diseases, Beaumont Hospital, D09 V2NO Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3738-1727","authenticated-orcid":false,"given":"Debbi","family":"Stanistreet","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health Medicine, Royal College of Surgeons in Ireland, D02 DH60 Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"McConkey","sequence":"additional","affiliation":[{"name":"Department of International Health and Tropical Medicine, Royal College of Surgeons in Ireland, D02 DH60 Dublin, Ireland"},{"name":"Department of Infectious Diseases, Beaumont Hospital, D09 V2NO Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eoghan","family":"de Barra","sequence":"additional","affiliation":[{"name":"Department of International Health and Tropical Medicine, Royal College of Surgeons in Ireland, D02 DH60 Dublin, Ireland"},{"name":"Department of Infectious Diseases, Beaumont Hospital, D09 V2NO Dublin, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,28]]},"reference":[{"key":"ref_1","unstructured":"World Health Organisation (2021, August 05). Global Tuberculosis Report 2020. Available online: https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/336069\/9789240013131-eng.pdf."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/S0140-6736(15)60570-0","article-title":"WHO\u2019s new end TB strategy","volume":"385","author":"Uplekar","year":"2015","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1183\/09031936.00214014","article-title":"Towards tuberculosis elimination: An action framework for low-incidence countries","volume":"45","author":"Migliori","year":"2015","journal-title":"Eur. Respir. J."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S2213-2600(14)70027-X","article-title":"Assessment of Mycobacterium tuberculosis transmission in Oxfordshire, UK, 2007\u20132012, with whole pathogen genome sequences: An observational study","volume":"2","author":"Walker","year":"2014","journal-title":"Lancet Respir. Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1093\/aje\/kwt246","article-title":"Estimated rate of reactivation of latent tuberculosis infection in the United States, overall and by population subgroup","volume":"179","author":"Shea","year":"2014","journal-title":"Am. J. Epidemiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1802077","DOI":"10.1183\/13993003.02077-2018","article-title":"Guidance for programmatic management of latent tuberculosis infection in the European Union\/European Economic Area","volume":"53","author":"Bruchfeld","year":"2019","journal-title":"Eur Respir. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1749-6632.1963.tb16633.x","article-title":"The use of chemotherapy as a prophylactic measure in tuberculosis","volume":"106","author":"Ferebee","year":"1963","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_8","first-page":"490","article-title":"Tuberculosis morbidity in a controlled trial of the prophylactic use of isoniazid among household contacts. American Review of Respiratory Disease","volume":"85","author":"Ferebee","year":"1962","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_9","unstructured":"Health Protection Surveillance Centre (2021, August 06). National TB Surveillance 2019. Available online: https:\/\/www.hpsc.ie\/a-z\/vaccinepreventable\/tuberculosistb\/tbdataandreports\/2019_Q1-4_TB_v1.0.pdf."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"100142","DOI":"10.1016\/j.jctube.2020.100142","article-title":"Identifying gaps in the quality of latent tuberculosis infection care","volume":"18","author":"Alsdurf","year":"2020","journal-title":"J. Clin. Tuberc. Other Mycobact. Dis."},{"key":"ref_11","unstructured":"O\u2019Connell, J., de Barra, E., and McConkey, S. (2021). Systematic review of latent tuberculosis infection research to inform programmatic management in Ireland. Ir. J. Med. Sci., 1\u201320."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Baker, A. (2001). Crossing the Quality Chasm: A New Health System for the 21st Century, British Medical Journal Publishing Group.","DOI":"10.1136\/bmj.323.7322.1192"},{"key":"ref_13","unstructured":"World Health Organization (2021, August 05). Delivering Quality Health Services: A Global Imperative for Universal Health Coverage. Available online: https:\/\/apps.who.int\/iris\/handle\/10665\/272465."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/S1473-3099(16)30216-X","article-title":"The cascade of care in diagnosis and treatment of latent tuberculosis infection: A systematic review and meta-analysis","volume":"16","author":"Alsdurf","year":"2016","journal-title":"Lancet Infect. Dis."},{"key":"ref_15","unstructured":"National Health Service (2021, July 11). National Latent TB Infection Testing and Treatment Programme England, Available online: https:\/\/www.england.nhs.uk\/tuberculosis-programme\/area-for-action-8-national-latent-tb-infection-testing-and-treatment-programme\/."},{"key":"ref_16","unstructured":"Assumpta, K., and O\u2019Connell, J. Personal Communication."},{"key":"ref_17","unstructured":"Bernardrine Luttrell, and O\u2019Connell, J. Personal Communication."},{"key":"ref_18","unstructured":"(2021, March 07). Public Spending Code E.01 Calculation of Staff Costs, Available online: https:\/\/govacc.per.gov.ie\/wp-content\/uploads\/Public-Spending-Code-Consolidated-Document.pdf."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jclinepi.2007.11.006","article-title":"STROBE-A checklist to Strengthen the Reporting of Observational Studies in Epidemiology","volume":"61","author":"Knottnerus","year":"2008","journal-title":"J. Clin. Epidemiol."},{"key":"ref_20","unstructured":"World Health Organization (2022, January 21). Tuberculosis Profiles. Available online: https:\/\/worldhealthorg.shinyapps.io\/tb_profiles\/?_inputs_&entity_type=%22country%22&lan=%22EN%22&iso2=%22AF%22."},{"key":"ref_21","unstructured":"StataCorp (2019). Stata Statistical Software, StataCorp LLC.. Release 16."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1492","DOI":"10.1183\/13993003.01397-2015","article-title":"Monitoring latent tuberculosis infection diagnosis and management in the Netherlands","volume":"47","author":"Erkens","year":"2016","journal-title":"Eur. Respir. J."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/ecco-jcc\/jjx108","article-title":"The prevalence of latent tuberculosis and hepatitis B after systematic screening of patients prescribed biological therapy in a low-endemic area","volume":"12","author":"Roosen","year":"2018","journal-title":"J. Crohns Colitis"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1136\/flgastro-2017-100951","article-title":"Challenges in screening for latent tuberculosis in inflammatory bowel disease prior to biologic treatment: A UK cohort study","volume":"9","author":"Thi","year":"2018","journal-title":"Frontline Gastroenterol."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Dobler, C.C., and Marks, G.B. (2012). Completion of treatment for latent tuberculosis infection with monthly drug dispensation directly through the tuberculosis clinic. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0048900"},{"key":"ref_26","first-page":"406","article-title":"A Survey of Latent Tuberculosis Screening and Treatment Practices in a Tertiary Centre","volume":"114","author":"McNally","year":"2021","journal-title":"Ir. Med. J."},{"key":"ref_27","unstructured":"O\u2019Meara, M. (2007). An Evaluation of TB Service Delivery in the Northern Area Health Board. [Ph.D. Thesis, Faculty of Public Health Medicine, Royal College of Physicians of Ireland]."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1007\/s11845-021-02541-2","article-title":"Symptoms to script: Delays in tuberculosis treatment in the west of Ireland","volume":"191","author":"Grant","year":"2022","journal-title":"Ir. J. Med. Sci."},{"key":"ref_29","unstructured":"Price, M.A. (2008). A Qualitative Study to Explore the Lived Experiences of Patients with Tuberculosis in the Community. [Ph.D. Thesis, Royal College of Surgeons in Ireland]."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"491","DOI":"10.5588\/ijtld.21.0033","article-title":"The largest prison outbreak of TB in Western Europe investigated using whole-genome sequencing","volume":"25","author":"Roycroft","year":"2021","journal-title":"Int. J. Tuberc. Lung Dis."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"e272","DOI":"10.1016\/S1473-3099(21)00077-3","article-title":"Barriers and enablers to implementing tuberculosis control strategies in EU and European Economic Area countries: A systematic review","volume":"21","author":"Conroy","year":"2021","journal-title":"Lancet Infect. Dis."},{"key":"ref_32","first-page":"508","article-title":"Barriers and facilitators of a latent tuberculosis screening and treatment programme of recent migrants","volume":"56","author":"Ikram","year":"2020","journal-title":"Eur Respir. J."},{"key":"ref_33","unstructured":"(2020, May 31). Healthatlas Ireland NQAIS Clinical. Available online: https:\/\/www.healthatlasireland.ie\/."},{"key":"ref_34","unstructured":"Health Protection Surveillance Centre (2021, August 05). Guidelines on the Prevention and Control of Tuberculosis in Ireland 2010. Available online: https:\/\/www.hpsc.ie\/a-z\/vaccinepreventable\/tuberculosistb\/guidance\/tbguidelines2010amended2014\/File,4349,en.pdf."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/2\/19\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:09:55Z","timestamp":1760134195000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/2\/19"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,28]]},"references-count":34,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["tropicalmed7020019"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed7020019","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,28]]}}}