{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:36:20Z","timestamp":1789986980724,"version":"4.0.1"},"reference-count":9,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T00:00:00Z","timestamp":1646352000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Mounting evidence indicates that new arrhythmic events frequently occur during and after coronavirus disease (COVID-19), posing additional mortality risk in older-aged and critically ill patients. However, the underlying mechanisms and cardio pathological substrates of COVID-related arrhythmias have not been clarified yet. Here, we report findings of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigens and genes in the atrioventricular node (AV-node) of a cardiac conduction system, pointing to its direct infection as a possible arrhythmogenic factor.<\/jats:p>","DOI":"10.3390\/tropicalmed7030043","type":"journal-article","created":{"date-parts":[[2022,3,6]],"date-time":"2022-03-06T20:40:38Z","timestamp":1646599238000},"page":"43","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Detection of SARS-CoV-2 Antigens in the AV-Node of a Cardiac Conduction System\u2014A Case Report"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8174-5124","authenticated-orcid":false,"given":"Hrvoje","family":"Jakovac","sequence":"first","affiliation":[{"name":"Department of Physiology, Immunology and Pathophysiology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antun","family":"Feren\u010di\u0107","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Criminalistics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Stemberger","sequence":"additional","affiliation":[{"name":"Department of Pathology, Clinical Hospital Centre Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bojana","family":"Mohar Vitezi\u0107","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Parasitology, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dra\u017een","family":"Cuculi\u0107","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine and Criminalistics, Faculty of Medicine, University of Rijeka, 51000 Rijeka, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1093\/europace\/euaa258","article-title":"Electrocardiographic features of 431 consecutive, critically ill COVID-19 patients: An insight into the mechanisms of cardiac involvement","volume":"22","author":"Bertini","year":"2020","journal-title":"Europace"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/j.hrthm.2020.06.016","article-title":"COVID-19 and cardiac arrhythmias","volume":"17","author":"Bhatla","year":"2020","journal-title":"Heart Rhythm"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/europace\/euaa333","article-title":"High-degree atrioventricular block in COVID-19 hospitalized patients","volume":"23","author":"Dagher","year":"2021","journal-title":"Europace"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.hrtlng.2022.01.001","article-title":"Incidence of cardiac complications following COVID-19 infection: An umbrella meta-analysis study","volume":"52","author":"Moradian","year":"2022","journal-title":"Heart Lung"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jjcc.2021.11.019","article-title":"COVID-19 and arrhythmia: An overview","volume":"79","author":"Varney","year":"2022","journal-title":"J. Cardiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1038\/s41598-022-04852-5","article-title":"Arrhythmogenic mechanisms of interleukin-6 combination with hydroxychloroquine and azithromycin in inflammatory diseases","volume":"12","author":"Zhu","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_7","first-page":"100084","article-title":"Arrhythmia patterns during and after hospitalization for COVID-19 infection detected via patch-based mobile cardiac telemetry","volume":"13","author":"Reynbakh","year":"2022","journal-title":"Am. Heart J. Plus"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/cjp2.212","article-title":"Characterisation of cardiac pathology in 23 autopsies of lethal COVID-19","volume":"7","author":"Haslbauer","year":"2021","journal-title":"J. Pathol. Clin. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1001\/jamacardio.2020.3551","article-title":"Association of Cardiac Infection With SARS-CoV-2 in Confirmed COVID-19 Autopsy Cases","volume":"5","author":"Lindner","year":"2020","journal-title":"JAMA Cardiol."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/3\/43\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:32:27Z","timestamp":1760135547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/3\/43"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":9,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,3]]}},"alternative-id":["tropicalmed7030043"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed7030043","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,4]]}}}