{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:17:51Z","timestamp":1760228271506,"version":"build-2065373602"},"reference-count":30,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>The present study aimed at analyzing the serum levels of mannose-binding lectin (MBL) and ficolin-3 (FCN3) in leprosy patients and their healthy family contacts in a hyperendemic region in northeastern Brazil. A cross-sectional study was carried out with 90 patients who had been diagnosed with leprosy and 79 healthy family contacts. Serum levels of the MBL and FCN3 proteins were measured using the immunofluorometric assay (ELISA). Clinical information was determined from the patients\u2019 charts. It was observed that the leprosy patients were more likely to be male (OR = 2.17; p = 0.01) and younger than fifteen years of age (OR = 2.01; p = 0.03) when compared to the family contacts. Those under 15 years of age had higher levels of MBL (4455 ng\/mL) than those over 15 years of age (2342 ng\/mL; p = 0.018). Higher FCN3 levels were identified in patients with indeterminate leprosy (41.9 \u00b5g\/mL) compared to those with the lepromatous form (34.3 \u00b5g\/mL; p = 0.033) and in those with no physical disabilities (38.1 \u00b5g\/mL) compared to those with some disability (p = 0.031). Higher FCN3 levels were also observed in the group of patients without leprosy reactions (37.4 \u00b5g\/mL) compared to those with type 1 (33.7 \u00b5g\/mL) and type 2 (36.1 \u00b5g\/mL) reactions. The MBL levels were higher in children under 15 years of age than they were in adults. It was evidenced that higher FCN3 serum levels were associated with early and transient clinical forms and lower expression in severe forms of leprosy.<\/jats:p>","DOI":"10.3390\/tropicalmed7050071","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T21:52:11Z","timestamp":1652219531000},"page":"71","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Serum Levels of Ficolin-3 and Mannose-Binding Lectin in Patients with Leprosy and Their Family Contacts in a Hyperendemic Region in Northeastern Brazil"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3226-6917","authenticated-orcid":false,"given":"Francisca Jacinta Feitoza de","family":"Oliveira","sequence":"first","affiliation":[{"name":"Social Sciences, Health and Technology Institute, Universidade Federal do Maranh\u00e3o, Av. da Universidade, s\/n Dom Afonso Felipe Gregory, Imperatriz 65915-240, Brazil"},{"name":"Clinical Immunology, Centro Universitario FMABC, Santo Andr\u00e9 09060-870, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida Alves de Oliveira","family":"Serra","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade e Tecnologia, Centro de Ci\u00eancias Sociais, Sa\u00fade e Tecnologia, Universidade Federal do Maranh\u00e3o, Eus\u00e9bio 61773-270, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo Hunaldo dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Sa\u00fade e Tecnologia, Centro de Ci\u00eancias Sociais, Sa\u00fade e Tecnologia, Universidade Federal do Maranh\u00e3o, Eus\u00e9bio 61773-270, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcio Fl\u00e1vio Moura de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz (FIOCRUZ), Euz\u00e9bio 61760-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosemeire Navickas Constantino da","family":"Silva","sequence":"additional","affiliation":[{"name":"Clinical Immunology, Centro Universitario FMABC, Santo Andr\u00e9 09060-870, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9803-0309","authenticated-orcid":false,"given":"Anete Sevciovic","family":"Grumach","sequence":"additional","affiliation":[{"name":"Clinical Immunology, Centro Universitario FMABC, Santo Andr\u00e9 09060-870, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4102\/safp.v63i1.5311","article-title":"Leprosy review","volume":"63","author":"Makhakhe","year":"2021","journal-title":"S. 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