{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:01:29Z","timestamp":1760230889686,"version":"build-2065373602"},"reference-count":25,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Gemella morbillorum is a facultative anaerobic, catalase-negative and non-spore forming Gram-positive cocci. It can be found as part of the normal oropharyngeal flora, in the gastrointestinal tract and the female genital tract. However, it can be a causal agent of infections such as endocarditis, meningitis or brain abscesses, and very rarely can cause osteoarticular infections. Herein, a case report of an acute hematogenous prosthetic hip infection caused by Gemella morbillorum, successfully treated with a DAIR and beta-lactam antibiotic therapy, is presented. We provide a literature review of the other orthopedic-related infections caused by this microorganism.<\/jats:p>","DOI":"10.3390\/tropicalmed7080191","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T02:48:23Z","timestamp":1660877303000},"page":"191","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Acute Hematogenous Periprosthetic Hip Infection by Gemella morbillorum, Successfully Treated with Debridement, Antibiotics and Implant Retention: A Case Report and Literature Review of Osteoarticular Gemella morbillorum Infections"],"prefix":"10.3390","volume":"7","author":[{"given":"Albert","family":"Pardo-Pol","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"P\u00e9rez-Prieto","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Alier","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1798-6876","authenticated-orcid":false,"given":"Lucas","family":"Ilzarbe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Llu\u00efsa","family":"Sorl\u00ed","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital del Mar, Infectious Pathology and Antimicrobial Research Group (IPAR), Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lluis","family":"Puig","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santos","family":"Mart\u00ednez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hospital del Mar, Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joan","family":"G\u00f3mez-Junyent","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Hospital del Mar, Infectious Pathology and Antimicrobial Research Group (IPAR), Institut Hospital del Mar d\u2019Investigacions M\u00e8diques (IMIM), Universitat Aut\u00f2noma de Barcelona (UAB), CEXS-Universitat Pompeu Fabra, 08003 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"ref_1","first-page":"114","article-title":"Management of prosthetic joint infection","volume":"38","author":"Hosny","year":"2020","journal-title":"Surgery"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1302\/2058-5241.4.180092","article-title":"Periprosthetic joint infection: Current concepts and outlook","volume":"4","author":"Izakovicova","year":"2019","journal-title":"EFORT Open Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1056\/NEJMra040181","article-title":"Prosthetic-Joint Infections","volume":"351","author":"Zimmerli","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1001\/jama.1917.04270040016008","article-title":"The cultivation of a micrococcus from blood in pre-eruptive and eruptive stages of measles","volume":"68","author":"Tunicliff","year":"1917","journal-title":"J. Am. Med. Assoc."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/0140-6736(93)91691-E","article-title":"Infections caused by Gemella morbillorum","volume":"342","author":"Wood","year":"1993","journal-title":"Lancet"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"3090","DOI":"10.1128\/JCM.36.10.3090-3093.1998","article-title":"Description of Gemella sanguinis sp. nov.; isolated from human clinical specimens","volume":"36","author":"Collins","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0002-9343(01)00783-5","article-title":"Gemella morbillorum bacteremia associated with adenocarcinoma of the cecum","volume":"111","author":"Reyes","year":"2001","journal-title":"Am. J. Med."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1253\/jcj.65.997","article-title":"Recurrent aortic valve endocarditis caused by Gemella morbillorum: Report of a case and review of the literature","volume":"65","author":"Akiyama","year":"2001","journal-title":"Jpn. Circ. J."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/clinids\/22.2.379","article-title":"Association of Gemella morbillorum endocarditis with adenomatous polyps and carcinoma of the colon: Case report and review","volume":"22","author":"Creus","year":"1996","journal-title":"Clin. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1128\/JCM.36.4.866-871.1998","article-title":"Molecular identification of Gemella species from three patients with endocarditis","volume":"36","author":"Raoult","year":"1998","journal-title":"J. Clin. Microbiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1099\/jmm.0.013367-0","article-title":"Gemella morbillorum: An underestimated aetiology of central nervous system infection?","volume":"58","author":"Benedetti","year":"2009","journal-title":"J. Med. Microbiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1136\/jcp.56.9.690","article-title":"Gemella bacteraemia characterised by 16S ribosomal RNA gene sequencing","volume":"56","author":"Woo","year":"2003","journal-title":"J. Clin. Pathol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1111\/1756-185X.13293","article-title":"Septic arthritis of the knee due to Gemella morbillorum","volume":"21","author":"Desmottes","year":"2018","journal-title":"Int. J. Rheum. Dis."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1157\/13109993","article-title":"Infection of a total hip arthroplasty due to Gemella morbillorum","volume":"25","year":"2007","journal-title":"Enferm. Infecc. Microbiol. Clin."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jinf.2005.01.009","article-title":"A case of septic arthritis due to infection with Gemella morbillorum","volume":"51","author":"Roche","year":"2005","journal-title":"J. Infect."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0732-8893(93)90007-T","article-title":"Endovascular infection and septic arthritis caused by Gemella morbillorum","volume":"16","author":"Omran","year":"1993","journal-title":"Diagn. Microbiol. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1007\/s100960050356","article-title":"Trochanter osteomyelitis and ipsilateral arthritis due to Gemella morbillorum","volume":"18","author":"Wuisman","year":"1999","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"ref_18","first-page":"7","article-title":"Gemella morbillorum septic arthritis of the knee and infective endocarditis","volume":"36","author":"Czarnecki","year":"2007","journal-title":"Am. J. Orthop."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0140-6736(93)91383-W","article-title":"Isolation of Gemella morbillorum from joint fluid","volume":"342","author":"Ikavalko","year":"1993","journal-title":"Lancet"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/cid\/cis966","article-title":"Diagnosis and management of prosthetic joint infection: Clinical practice guidelines by the infectious diseases Society of America","volume":"56","author":"Osmon","year":"2013","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1302\/0301-620X.103B1.BJJ-2020-1381.R1","article-title":"The EBJIS definition of periprosthetic joint infection","volume":"103","author":"McNally","year":"2021","journal-title":"Bone Jt. J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jinf.2018.07.014","article-title":"Clinical outcome and risk factors for failure in late acute prosthetic joint infections treated with debridement and implant retention","volume":"78","author":"Sebillotte","year":"2019","journal-title":"J. Infect."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1080\/17474124.2018.1481747","article-title":"Bacterial translocation in patients with liver cirrhosis: Physiology, clinical consequences, and practical implications","volume":"12","author":"Ponziani","year":"2018","journal-title":"Expert Rev. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s11938-019-00229-2","article-title":"Infections in Cirrhosis","volume":"17","author":"Ekpanyapong","year":"2019","journal-title":"Curr. Treat. Options Gastroenterol."},{"key":"ref_25","first-page":"17","article-title":"Evaluation of Cases with Gemella Infection: Cross-Sectional Study","volume":"4","author":"Esma","year":"2018","journal-title":"J. Infect. Dis. Epidemiol."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/8\/191\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:11:34Z","timestamp":1760141494000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/8\/191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,18]]},"references-count":25,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["tropicalmed7080191"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed7080191","relation":{},"ISSN":["2414-6366"],"issn-type":[{"type":"electronic","value":"2414-6366"}],"subject":[],"published":{"date-parts":[[2022,8,18]]}}}