{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:35:19Z","timestamp":1791909319748,"version":"4.3.4"},"reference-count":45,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T00:00:00Z","timestamp":1660780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Leptospirosis is a bacterial zoonosis caused by pathogenic Leptospira that are maintained in the kidney lumen of infected animals acting as reservoirs and contaminating the environment via infected urine. The investigation of leptospirosis through a One Health framework has been stimulated by notable genetic diversity of pathogenic Leptospira combined with a high infection prevalence in certain animal reservoirs. Studies of Madagascar\u2019s native mammal fauna have revealed a diversity of Leptospira with high levels of host-specificity. Native rodents, tenrecids, and bats shelter several distinct lineages and species of Leptospira, some of which have also been detected in acute human cases. Specifically, L. mayottensis, first discovered in humans on Mayotte, an island neighboring Madagascar, was subsequently identified in a few species of tenrecids on the latter island, which comprise an endemic family of small mammals. Distinct L. mayottensis lineages were identified in shrew tenrecs (Microgale cowani and Nesogale dobsoni) on Madagascar, and later in an introduced population of spiny tenrecs (Tenrec ecaudatus) on Mayotte. These findings suggest that L. mayottensis (i) has co-radiated with tenrecids on Madagascar, and (ii) has recently emerged in human populations on Mayotte following the introduction of T. ecaudatus from Madagascar. Hitherto, L. mayottensis has not been detected in spiny tenrecs on Madagascar. In the present study, we broaden the investigation of Malagasy tenrecids and test the emergence of L. mayottensis in humans as a result of the introduction of T. ecaudatus on Mayotte. We screened by PCR 55 tenrecid samples from Madagascar, including kidney tissues from 24 individual T. ecaudatus. We describe the presence of L. mayottensis in Malagasy T. ecaudatus in agreement with the aforementioned hypothesis, as well as in M. thomasi, a tenrecid species that has not been explored thus far for Leptospira carriage.<\/jats:p>","DOI":"10.3390\/tropicalmed7080193","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T02:48:23Z","timestamp":1660877303000},"page":"193","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Co-Radiation of Leptospira and Tenrecidae (Afrotheria) on Madagascar"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7700-9201","authenticated-orcid":false,"given":"Yann","family":"Gomard","sequence":"first","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Universit\u00e9 de La R\u00e9union, CNRS 9192, INSERM 1187, IRD 249, Plateforme Technologique CYROI, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9318-0570","authenticated-orcid":false,"given":"Steven M.","family":"Goodman","sequence":"additional","affiliation":[{"name":"Association Vahatra, BP 3972, Antananarivo 101, Madagascar"},{"name":"Field Museum of Natural History, Chicago, IL 60605, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Voahangy","family":"Soarimalala","sequence":"additional","affiliation":[{"name":"Association Vahatra, BP 3972, Antananarivo 101, Madagascar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magali","family":"Turpin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Universit\u00e9 de La R\u00e9union, CNRS 9192, INSERM 1187, IRD 249, Plateforme Technologique CYROI, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guena\u00eblle","family":"Lenclume","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Universit\u00e9 de La R\u00e9union, CNRS 9192, INSERM 1187, IRD 249, Plateforme Technologique CYROI, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Ah-Vane","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Universit\u00e9 de La R\u00e9union, CNRS 9192, INSERM 1187, IRD 249, Plateforme Technologique CYROI, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-7493","authenticated-orcid":false,"given":"Christopher D.","family":"Golden","sequence":"additional","affiliation":[{"name":"Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA 02115, USA"},{"name":"Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, MA 02115, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-7264","authenticated-orcid":false,"given":"Pablo","family":"Tortosa","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Mixte de Recherche Processus Infectieux en Milieu Insulaire Tropical (UMR PIMIT), Universit\u00e9 de La R\u00e9union, CNRS 9192, INSERM 1187, IRD 249, Plateforme Technologique CYROI, 97490 Sainte-Clotilde, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Costa, F., Hagan, J.E., Calcagno, J., Kane, M., Torgerson, P., Martinez-Silveira, M.S., Stein, C., Abela-Ridder, B., and Ko, A.I. 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