{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T22:24:35Z","timestamp":1785363875167,"version":"3.55.0"},"reference-count":103,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Universidad San Ignacio de Loyola","award":["20297868790"],"award-info":[{"award-number":["20297868790"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Reducing neonatal mortality is a global challenge. This study\u2019s objective was to determine the predictors of mortality in patients with neonatal sepsis. The study was a retrospective cohort study in a Peruvian hospital from January 2014 to April 2022. Neonates diagnosed with sepsis were included. To find predictors of mortality, we used Cox proportional regression models. We evaluated 288 neonates with sepsis; the median birth weight and hospitalization time were 3270 g and seven days, respectively. During follow-up, 18.4% did not survive, and the most common complications were jaundice (35.42%), respiratory distress syndrome (29.51%), and septic shock (12.5%). The most isolated bacteria were Klebsiella pneumoniae. The risk factors associated with higher mortality were prematurity (aHR = 13.92; 95% CI: 1.71\u2013113.51), platelets &lt;150,000 (aHR = 3.64; 1.22\u201310.88), creatinine greater than 1.10 (aHR = 3.03; 1.09\u20138.45), septic shock (aHR = 4.41; 2.23\u20138.74), and admission to IMV (aHR = 5.61; 1.86\u201316.88), On the other hand, breastfeeding was associated with a lower risk of death (aHR = 0.25; 0.13\u20130.48). In conclusion, we report a high incidence of death and identify clinical (prematurity, septic shock, admission to IMV) and laboratory characteristics (elevated creatinine and thrombocytopenia) associated with higher mortality in patients with neonatal sepsis. Breastfeeding was a factor associated with survival in these patients.<\/jats:p>","DOI":"10.3390\/tropicalmed7110342","type":"journal-article","created":{"date-parts":[[2022,11,2]],"date-time":"2022-11-02T03:44:17Z","timestamp":1667360657000},"page":"342","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Predictors of Death in Patients with Neonatal Sepsis in a Peruvian Hospital"],"prefix":"10.3390","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3130-7657","authenticated-orcid":false,"given":"Dariela","family":"Vizcarra-Jim\u00e9nez","sequence":"first","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna 23003, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9982-5368","authenticated-orcid":false,"given":"Cesar","family":"Copaja-Corzo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna 23003, Peru"},{"name":"Red Asistencial Ucayali EsSalud, Ucayali 25003, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Hueda-Zavaleta","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna 23003, Peru"},{"name":"Hospital III Daniel Alcides Carrion EsSalud, Tacna 23000, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar G.","family":"Parihuana-Traveza\u00f1o","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna 23003, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maykel","family":"Gutierrez-Flores","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna 23003, Peru"},{"name":"Hospital Hip\u00f3lito Unanue de Tacna, Tacna 23003, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7317-9177","authenticated-orcid":false,"given":"Marco","family":"Rivarola-Hidalgo","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias de la Salud, Universidad Privada de Tacna, Tacna 23003, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente A.","family":"Benites-Zapata","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n para la Generaci\u00f3n y S\u00edntesis de Evidencias en Salud, Universidad San Ignacio de Loyola, Lima 15024, Peru"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"ref_1","unstructured":"United Nations (2022, June 25). 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