{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:32:55Z","timestamp":1787625175239,"version":"build-2736575974"},"reference-count":13,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,11]],"date-time":"2022-12-11T00:00:00Z","timestamp":1670716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Objectives: In COVID-19 patients, bacterial and fungal pulmonary coinfections, such as Streptococcus pneumoniae, Staphylococcus aureus, Haemophilus influenzae, or Aspergillus, have been reported, but to our knowledge, no case has been reported due to Pasteurella multocida. Patients and methods: We describe three cases of Pasteurella multocida coinfections occurring during the 4th wave of COVID-19 in Martinique (French West Indies). Results: All three cases were fatal; thus, Pasteurella multocida has to be considered as a potentially severe coinfection agent. Conclusions: Alteration of the epithelial\u2013endothelial barrier due to a SARS-CoV-2 infection probably promotes the expression of a Pasteurella infection. In addition, the SARS-CoV-2 infection induced immunosuppression, and an inflammatory cascade could explain the infection\u2019s severity. The use of corticosteroids, which are part of the first-line therapeutic arsenal against COVID-19, may also promote the pathogenicity of this agent.<\/jats:p>","DOI":"10.3390\/tropicalmed7120429","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T04:05:22Z","timestamp":1670817922000},"page":"429","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["COVID-19 and Pasteurella multocida Pulmonary Coinfection: A Case Series"],"prefix":"10.3390","volume":"7","author":[{"given":"Ornella","family":"Cabras","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Martinique, 97200 Fort-de-France, France"},{"name":"Pathogenesis and Controle of Chronic and Emerging Infections, Univ Montpellier, Univ Antilles, INSERM, EFS, 34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marie","family":"Turmel","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Olive","sequence":"additional","affiliation":[{"name":"Bacteriology Department, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bastien","family":"Bigeard","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Lehoux","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Pierre-Francois","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Guitteaud","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Martinique, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Abel","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Martinique, 97200 Fort-de-France, France"},{"name":"Pathogenesis and Controle of Chronic and Emerging Infections, Univ Montpellier, Univ Antilles, INSERM, EFS, 34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise","family":"Cuzin","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Martinique, 97200 Fort-de-France, France"},{"name":"CERPOP, Universit\u00e9 de Toulouse, Inserm UMR1295, UPS, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Cabi\u00e9","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital of Martinique, 97200 Fort-de-France, France"},{"name":"Pathogenesis and Controle of Chronic and Emerging Infections, Univ Montpellier, Univ Antilles, INSERM, EFS, 34000 Montpellier, France"},{"name":"Center of Clinical Investigation of Antilles Guyane, INSERM 1424, 97200 Fort-de-France, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1016\/j.cmi.2020.07.016","article-title":"Bacterial Co-Infection and Secondary Infection in Patients with COVID-19: A Living Rapid Review and Meta-Analysis","volume":"26","author":"Langford","year":"2020","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1128\/CMR.00024-13","article-title":"Pasteurella Multocida: From Zoonosis to Cellular Microbiology","volume":"26","author":"Wilson","year":"2013","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"361","DOI":"10.5114\/pjr.2020.98009","article-title":"COVID-19 Severity Scoring Systems in Radiological Imaging\u2014A Review","volume":"85","author":"Wasilewski","year":"2020","journal-title":"Pol. J. Radiol."},{"key":"ref_4","first-page":"54","article-title":"Pneumonia and Disseminated Bacteremia with Pasteurella Multocida in the Immune Competent Host: A Case Report and a Review of the Literature","volume":"15","author":"Ferreira","year":"2015","journal-title":"Respir. Med. Case Rep."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00005792-198405000-00001","article-title":"Pasteurella Multocida Infections. Report of 34 Cases and Review of the Literature","volume":"63","author":"Weber","year":"1984","journal-title":"Medicine"},{"key":"ref_6","first-page":"54","article-title":"Pasteurella Multocida Pneumonia","volume":"12","author":"Klein","year":"1997","journal-title":"Semin. Respir. Infect."},{"key":"ref_7","first-page":"80","article-title":"Occupationally Acquired Pasteurella Multocida Pneumonia in a Healthy Abattoir Worker","volume":"19","author":"Pradeepan","year":"2016","journal-title":"Respir. Med. Case Rep."},{"key":"ref_8","first-page":"e14232","article-title":"A Rare Case of Bacteremic Community-Acquired Pneumonia Due to Pasteurella Multocida Presenting With Hemoptysis","volume":"13","author":"Ayas","year":"2021","journal-title":"Cureus"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e81","DOI":"10.1016\/j.ijid.2008.06.023","article-title":"Bacteremic Community-Acquired Pneumonia Due to Pasteurella Multocida","volume":"13","author":"Kofteridis","year":"2009","journal-title":"Int. J. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s15010-007-5074-7","article-title":"Isolated Endocarditis of the Pulmonary Valve Caused by Pasteurella Multocida","volume":"35","author":"Graf","year":"2007","journal-title":"Infection"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.18683\/germs.2019.1177","article-title":"Hemoptysis. Is It Caused by Pasteurella Multocida Infection or Congenital Pulmonary Artery Anomalies?","volume":"9","author":"Jankovic","year":"2019","journal-title":"Germs"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.4103\/lungindia.lungindia_482_17","article-title":"Pasteurella Multocida Pneumonia in an Immunocompetent Patient: Case Report and Systematic Review of Literature","volume":"35","author":"Pak","year":"2018","journal-title":"Lung India"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"e00014-19","DOI":"10.1128\/MMBR.00014-19","article-title":"Pasteurella Multocida: Genotypes and Genomics","volume":"83","author":"Peng","year":"2019","journal-title":"Microbiol. Mol. Biol. Rev."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/12\/429\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:39:25Z","timestamp":1760146765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/7\/12\/429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,11]]},"references-count":13,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12]]}},"alternative-id":["tropicalmed7120429"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed7120429","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,11]]}}}