{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T01:58:36Z","timestamp":1792807116996,"version":"4.5.0"},"reference-count":101,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian agencies Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","id":[{"id":"https:\/\/ror.org\/03swz6y49","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior (CAPES)","id":[{"id":"https:\/\/ror.org\/00x0ma614","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio Grande do Sul (FAPERGS)","id":[{"id":"https:\/\/ror.org\/05k49za97","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>The human anaerobic or microaerophilic protists Giardia duodenalis, Entamoeba histolytica, and Trichomonas vaginalis are classified as amitochondriate parasites, a group of unicellular organisms that lack canonical mitochondria organelles. These microorganisms suffered adaptations to survive in hostile microenvironments and together represent an increasing threat to public health in developing countries. Nevertheless, the current therapeutic drugs to manage the infections are scarce and often cause several side effects. Furthermore, refractory cases associated with the emergence of parasitic resistance are concerns that guide the search for new pharmacological targets and treatment alternatives. Herein, essential oils and terpenic compounds with activity against amitochondriate parasites with clinical relevance are summarized and insights into possible mechanisms of action are made. This review aims to contribute with future perspectives for research with these natural products as potential alternatives for the acquisition of new molecules for the treatment of amitochondriate protists.<\/jats:p>","DOI":"10.3390\/tropicalmed8010037","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T03:36:05Z","timestamp":1672889765000},"page":"37","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Essential Oils and Terpenic Compounds as Potential Hits for Drugs against Amitochondriate Protists"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6657-585X","authenticated-orcid":false,"given":"Saulo Almeida","family":"Menezes","sequence":"first","affiliation":[{"name":"Grupo de Pesquisa em Tricomonas, Faculdade de Farm\u00e1cia e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av. Bento Gon\u00e7alves 9500, Porto Alegre 91501-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8334-5105","authenticated-orcid":false,"given":"Tiana","family":"Tasca","sequence":"additional","affiliation":[{"name":"Grupo de Pesquisa em Tricomonas, Faculdade de Farm\u00e1cia e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Av. Bento Gon\u00e7alves 9500, Porto Alegre 91501-970, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.cmi.2016.04.020","article-title":"Parasitic infections: Their position and impact in the postindustrial world","volume":"22","author":"Piperaki","year":"2016","journal-title":"Clin. Microbiol. 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