{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:44:07Z","timestamp":1760147047999,"version":"build-2065373602"},"reference-count":22,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22-75-10140"],"award-info":[{"award-number":["22-75-10140"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>The Chlorovirus genus of the Phycodnaviridae family includes large viruses with a double-stranded DNA genome. Chloroviruses are widely distributed in freshwater bodies around the world and have been isolated from freshwater sources in Europe, Asia, Australia, and North and South America. One representative of chloroviruses is Acanthocystis turfacea chlorella virus 1 (ATCV-1), which is hosted by Chlorella heliozoae. A few publications in the last ten years about the potential effects of ATCV-1 on the human brain sparked interest among specialists in the field of human infectious pathology. The goal of our viewpoint was to compile the scant research on the effects of ATCV-1 on the human body, to demonstrate the role of chloroviruses as new possible infectious agents for human health, and to indicate potential routes of virus transmission. We believe that ATCV-1 transmission routes remain unexplored. We also question whether chlorella-based nutritional supplements are dangerous for ATCV-1 infections. Further research will help to identify the routes of infection, the cell types in which ATCV-1 can persist, and the pathological mechanisms of the virus\u2019s effect on the human body.<\/jats:p>","DOI":"10.3390\/tropicalmed8010040","type":"journal-article","created":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T06:11:51Z","timestamp":1672899111000},"page":"40","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Role of Chloroviruses as Possible Infectious Agents for Human Health: Putative Mechanisms of ATCV-1 Infection and Potential Routes of Transmission"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8734-5527","authenticated-orcid":false,"given":"Yury V.","family":"Zhernov","sequence":"first","affiliation":[{"name":"Department of General Hygiene, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow StateMedical University (Sechenov University), 119435 Moscow, Russia"},{"name":"Center of Life Sciences, Skolkovo Institute of Science and Technology, 121205 Moscow, Russia"},{"name":"Department of Chemistry, Lomonosov Moscow State University, 119991 Moscow, Russia"},{"name":"Center for Medical Anthropology, N.N. Miklukho-Maclay Institute of Ethnology and Anthropology of the Russian Academy of Sciences, 119017 Moscow, Russia"},{"name":"Department of Medical and Biological Disciplines, Reaviz Medical University, 107564 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonya O.","family":"Vysochanskaya","sequence":"additional","affiliation":[{"name":"Department of General Hygiene, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow StateMedical University (Sechenov University), 119435 Moscow, Russia"},{"name":"Diphtheria and Pertussis Surveillance Laboratory, G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, 125212 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4167-3124","authenticated-orcid":false,"given":"Artem A.","family":"Basov","sequence":"additional","affiliation":[{"name":"Department of General Hygiene, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow StateMedical University (Sechenov University), 119435 Moscow, Russia"},{"name":"Diphtheria and Pertussis Surveillance Laboratory, G.N. Gabrichevsky Research Institute for Epidemiology and Microbiology, 125212 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vitaly A.","family":"Sukhov","sequence":"additional","affiliation":[{"name":"Department of General Hygiene, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow StateMedical University (Sechenov University), 119435 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton A.","family":"Simanovsky","sequence":"additional","affiliation":[{"name":"Department of General Hygiene, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow StateMedical University (Sechenov University), 119435 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5480-8732","authenticated-orcid":false,"given":"Inna A.","family":"Fadeeva","sequence":"additional","affiliation":[{"name":"Department of English Language, Institute of World Economy, Diplomatic Academy of the Russian Foreign Ministry, 119034 Moscow, Russia"},{"name":"Department of Public Administration in Foreign Policy, Diplomatic Academy of the Russian Foreign Ministry, 119034 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4146-4787","authenticated-orcid":false,"given":"Roman V.","family":"Polibin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Evidence-Based Medicine, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow State Medical University (Sechenov University), 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3817-4175","authenticated-orcid":false,"given":"Ekaterina A.","family":"Sidorova","sequence":"additional","affiliation":[{"name":"Department of General Hygiene, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow StateMedical University (Sechenov University), 119435 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis V.","family":"Shcherbakov","sequence":"additional","affiliation":[{"name":"Department of General Hygiene, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow StateMedical University (Sechenov University), 119435 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6403-0423","authenticated-orcid":false,"given":"Oleg V.","family":"Mitrokhin","sequence":"additional","affiliation":[{"name":"Department of General Hygiene, F. Erismann Institute of Public Health, I.M. Sechenov First Moscow StateMedical University (Sechenov University), 119435 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Jeanniard, A., Dunigan, D.D., Gurnon, J.R., Agarkova, I.V., Kang, M., Vitek, J., Duncan, G., McClung, O.W., Larsen, M., and Claverie, J.-M. (2013). Towards defining the chloroviruses: A genomic journey through a genus of large DNA viruses. 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