{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:01:45Z","timestamp":1760148105693,"version":"build-2065373602"},"reference-count":69,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T00:00:00Z","timestamp":1680048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","award":["001","440245\/2018-4","041\/2017"],"award-info":[{"award-number":["001","440245\/2018-4","041\/2017"]}]},{"name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro (FAPERJ)","award":["001","440245\/2018-4","041\/2017"],"award-info":[{"award-number":["001","440245\/2018-4","041\/2017"]}]},{"name":"Oswaldo Cruz Institute","award":["001","440245\/2018-4","041\/2017"],"award-info":[{"award-number":["001","440245\/2018-4","041\/2017"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico (CNPq)","award":["001","440245\/2018-4","041\/2017"],"award-info":[{"award-number":["001","440245\/2018-4","041\/2017"]}]},{"name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","award":["001","440245\/2018-4","041\/2017"],"award-info":[{"award-number":["001","440245\/2018-4","041\/2017"]}]},{"name":"Funda\u00e7\u00e3o de Apoio ao Desenvolvimento do Ensino, Ci\u00eancia e Tecnologia do Estado de Mato Grosso do Sul","award":["001","440245\/2018-4","041\/2017"],"award-info":[{"award-number":["001","440245\/2018-4","041\/2017"]}]},{"name":"Secretaria do Estado de Sa\u00fade of Mato Grosso do Sul","award":["001","440245\/2018-4","041\/2017"],"award-info":[{"award-number":["001","440245\/2018-4","041\/2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Sexually transmitted Human alphaherpesvirus 2 (HSV-2) causes genital ulcers, especially among sexually active adolescents and adults. We estimated the exact prevalence of anti-HSV-2 antibodies and correlated it with the demographic and behavioral aspects of the Indigenous population of the Jaguapir\u00fa and Boror\u00f3 villages (Dourados, Mato Grosso do Sul (MS), Brazil). In total, 1360 individuals (&gt;18 years old) were administered serologic tests. The prevalence of anti-HSV-2 IgM was 12.9%, that of anti-HSV-2 IgG was 57.2%, and 8.5% cases tested positive for both HSV-2 IgM and IgG. The prevalence of anti-HSV-2 antibodies was higher in females (59.5%) compared to males (49%), with an OR of 0.64 (0.49\u20130.83). Anti-HSV-2 antibodies were found in 14.2%, 12.3%, 15.4%, and 14.5% of participants with urinary problems, genital wounds, genital warts, and urethral discharge, respectively. In summary, the seroprevalence of HSV-2 in the Indigenous population was five times higher than that reported in the general adult Brazilian population. Educational level, income level, smoking, condom use, incarceration, illicit drug abuse, the sharing of used needles and syringes without adequate disinfection, homosexual relationships, prostitution, the sexual practices among drug users, and avoidance of contraceptive methods could contribute to the facilitation of HSV-2 transmission in the Indigenous population. Our results may help develop culturally appropriate intervention programs that eliminate health-access barriers and improve the implementation of public health policies aimed at promoting information regarding and preventing, treating, and controlling HSV-2 infection in Brazilian Indigenous populations.<\/jats:p>","DOI":"10.3390\/tropicalmed8040197","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T01:05:26Z","timestamp":1680138326000},"page":"197","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiological Survey of Human Alphaherpesvirus 2 (HSV-2) Infection in Indigenous People of Dourados Municipality, Central Brazil"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2816-5176","authenticated-orcid":false,"given":"Fl\u00e1via Freitas de Oliveira","family":"Bonfim","sequence":"first","affiliation":[{"name":"Virology Molecular Laboratory, Oswaldo Cruz Foundation, Rio de Janeiro 21040360, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7644-8969","authenticated-orcid":false,"given":"Livia Melo","family":"Villar","sequence":"additional","affiliation":[{"name":"Viral Hepatitis Laboratory, Oswaldo Cruz Foundation, Rio de Janeiro 21040360, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"Croda","sequence":"additional","affiliation":[{"name":"Brazilian Society of Tropical Medicine, Campo Grande 79070900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solange Rodrigues da","family":"Silva","sequence":"additional","affiliation":[{"name":"Binacional Campus of Oiapoque, Federal University of Amap\u00e1, Macap\u00e1 68903419, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Crhistinne Cavalheiro Maymone","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Center for Biological and Health Sciences, Blood Center Sector, Federal University of Mato Grosso do Sul, Campo Grande 79070900, Brazil"},{"name":"State Department of Health of Mato Grosso do Sul, Campo Grande 79031350, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3669-7888","authenticated-orcid":false,"given":"Vivianne de Oliveira Landgraf","family":"de Castro","sequence":"additional","affiliation":[{"name":"Environmental Analysis Laboratory, Southern Cross University, Military Road East, Lismore, NSW 2480, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazielli Rocha","family":"de Rezende Romeira","sequence":"additional","affiliation":[{"name":"Center for Biological and Health Sciences, Blood Center Sector, Federal University of Mato Grosso do Sul, Campo Grande 79070900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela Alves","family":"Cesar","sequence":"additional","affiliation":[{"name":"Center for Biological and Health Sciences, Blood Center Sector, Federal University of Mato Grosso do Sul, Campo Grande 79070900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3457-1675","authenticated-orcid":false,"given":"Sabrina Moreira","family":"dos Santos Weis-Torres","sequence":"additional","affiliation":[{"name":"Center for Biological and Health Sciences, Blood Center Sector, Federal University of Mato Grosso do Sul, Campo Grande 79070900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco Aur\u00e9lio","family":"Horta","sequence":"additional","affiliation":[{"name":"Biosafety Level 3 Platform (NB3), Oswaldo Cruz Foundation, Rio de Janeiro 21040360, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2367-0915","authenticated-orcid":false,"given":"Simone","family":"Simionatto","sequence":"additional","affiliation":[{"name":"College of Biological and Environmental Sciences, Federal University of Grande Dourados, Dourados 79070900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3070-1337","authenticated-orcid":false,"given":"Ana Rita Coimbra","family":"Motta-Castro","sequence":"additional","affiliation":[{"name":"Center for Biological and Health Sciences, Blood Center Sector, Federal University of Mato Grosso do Sul, Campo Grande 79070900, Brazil"},{"name":"Center for Health and Biological Sciences, Oswaldo Cruz Foundation, Rio de Janeiro 79070900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6314-754X","authenticated-orcid":false,"given":"Vanessa Salete","family":"de Paula","sequence":"additional","affiliation":[{"name":"Virology Molecular Laboratory, Oswaldo Cruz Foundation, Rio de Janeiro 21040360, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,29]]},"reference":[{"key":"ref_1","unstructured":"Brazilian Geographic and Statistics Institute (2022, October 26). 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