{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:15:45Z","timestamp":1787030145338,"version":"build-2736575974"},"reference-count":19,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPq","award":["308315\/2021-9"],"award-info":[{"award-number":["308315\/2021-9"]}]},{"name":"CNPq","award":["E-26\/200.381\/2023"],"award-info":[{"award-number":["E-26\/200.381\/2023"]}]},{"name":"FAPERJ","award":["308315\/2021-9"],"award-info":[{"award-number":["308315\/2021-9"]}]},{"name":"FAPERJ","award":["E-26\/200.381\/2023"],"award-info":[{"award-number":["E-26\/200.381\/2023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Objectives: Histoplasmosis is a systemic mycosis, present globally. We aimed to describe cases of histoplasmosis (Hc) and to establish a risk profile associated with Hc in HIV-infected patients (HIV+). Methods: This was a retrospective study of patients with a clinical laboratory diagnosis of Hc. Data were fed into REDCap, and statistical analysis was performed with R. Results: We included 99 records, 65 HIV+ and 34 HIV\u2212. Average age was 39 years. Median time from onset to diagnosis was 8 weeks in HIV\u2212 and 22 weeks in HIV+. Disseminated histoplasmosis occurred in 79.4% of HIV+, vs. 36.4% of HIV\u2212 patients. Median CD4 count was 70. Co-infection with tuberculosis was present in 20% of HIV+ patients. Blood cultures were positive in 32.3% of HIV+ vs. 11.8% of HIV\u2212 (p = 0.025) patients; bone marrow culture was positive in 36.9% vs. 8.8% (p = 0.003). Most HIV+ patients (71.4%) were hospitalized. On univariate analysis, anemia, leukopenia, intensive care, use of vasopressors and mechanical ventilation were associated with death in HIV+ patients. Conclusions: Most of our patients with histoplasmosis were HIV+, presenting advanced AIDS. Diagnosis was late in HIV+ patients, and they frequently presented disseminated Hc, required hospitalization, and died. Early screening for Hc in HIV+ and drug-induced immunosuppressed patients is crucial.<\/jats:p>","DOI":"10.3390\/tropicalmed8050271","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T03:49:06Z","timestamp":1683690546000},"page":"271","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Histoplasmosis at a Reference Center for Infectious Diseases in Southeast Brazil: Comparison between HIV-Positive and HIV-Negative Individuals"],"prefix":"10.3390","volume":"8","author":[{"given":"Ariane Gomes","family":"Paix\u00e3o","sequence":"first","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5581-631X","authenticated-orcid":false,"given":"Marcos Abreu","family":"Almeida","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Esp\u00edrito Santo","family":"Correia","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz Brittes","family":"Kamiensky","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosely Maria","family":"Zancop\u00e9-Oliveira","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcia dos Santos","family":"Lazera","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bodo","family":"Wanke","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5561-999X","authenticated-orcid":false,"given":"Cristiane da Cruz","family":"Lamas","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Infectologia Evandro Chagas, Fiocruz, Rio de Janeiro 21040-900, Brazil"},{"name":"Instituto Nacional de Cardiologia, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s40475-015-0044-0","article-title":"Histoplasmosis infections worldwide: Thinking outside of the Ohio River Valley","volume":"2","author":"Bahr","year":"2015","journal-title":"Curr. 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Fungi, 5.","DOI":"10.3390\/jof5030073"}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/8\/5\/271\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:31:55Z","timestamp":1760124715000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/8\/5\/271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,10]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5]]}},"alternative-id":["tropicalmed8050271"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed8050271","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,10]]}}}