{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:47:56Z","timestamp":1785552476331,"version":"3.56.0"},"reference-count":17,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Cystic echinococcosis is a zoonosis caused by the ingestion of food or water contaminated by Echinococcus eggs. E. granulosus is the most common causative agent of cystic echinococcosis that still has a relevant incidence in Italy, especially on the islands of Sicily and Sardinia. We report the case of a 64-year-old man with disseminated abdominal cystic echinococcosis (liver, spleen, peritoneum). The patient was asymptomatic and non-eligible for surgical treatment. Treatment with albendazole 400 mg\/twice daily was started in 2012 for 15 cycles (each cycle consisted of three 28-day treatments at 14-day intervals) over 10 years for a total of 1260 days of treatment. Serum anti-Echinococcus antibody titers and imaging (echography, TC) were evaluated to monitor the evolution of the disease. Imaging techniques documented the regression of all cyst lesions, but it was less evident for the peritoneal localizations that still are in follow-up. In this case, the prolonged treatment with albendazole was effective, safe and free of side effects. Until today, the patient displays a good clinical condition.<\/jats:p>","DOI":"10.3390\/tropicalmed8090449","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T04:06:13Z","timestamp":1694750773000},"page":"449","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Very Prolonged Treatment with Albendazole of a Case of Disseminated Abdominal Cystic Echinococcosis"],"prefix":"10.3390","volume":"8","author":[{"given":"Carola","family":"Buscemi","sequence":"first","affiliation":[{"name":"Unit of Internal Medicine, V. Cervello Hospital, I-90100 Palermo, Italy"},{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, I-90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiana","family":"Randazzo","sequence":"additional","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, I-90100 Palermo, Italy"},{"name":"Unit of Clinical Nutrition, AOU Policlinico \u201cP. Giaccone\u201d, I-90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5791-1502","authenticated-orcid":false,"given":"Paolo","family":"Buscemi","sequence":"additional","affiliation":[{"name":"Postgraduate School in Radiology, University of Palermo, I-90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Caldarella","sequence":"additional","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, I-90100 Palermo, Italy"},{"name":"Unit of Laboratory Medicine, AOU Policlinico \u201cP. Giaccone\u201d, I-90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Lombardo","sequence":"additional","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, I-90100 Palermo, Italy"},{"name":"Unit of Clinical Nutrition, AOU Policlinico \u201cP. Giaccone\u201d, I-90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0730-7649","authenticated-orcid":false,"given":"Silvio","family":"Buscemi","sequence":"additional","affiliation":[{"name":"Dipartimento di Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, I-90100 Palermo, Italy"},{"name":"Unit of Clinical Nutrition, AOU Policlinico \u201cP. Giaccone\u201d, I-90100 Palermo, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1128\/JCM.02420-15","article-title":"Cystic Echinococcosis","volume":"54","author":"Brunetti","year":"2016","journal-title":"J. Clin. Microbiol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/bs.apar.2016.11.001","article-title":"Global Distribution of Alveolar and Cystic Echinococcosis","volume":"95","author":"Deplazes","year":"2017","journal-title":"Adv. Parasitol."},{"key":"ref_3","first-page":"39","article-title":"Idatidosi cistica umana in Italia: Un problema di salute pubblica? Passato e presente [Human cystic hydatidosis in Italy: A public health emergency? 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Hyg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1148\/radiographics.20.3.g00ma06795","article-title":"Hydatid disease: Radiologic and pathologic features and complications","volume":"20","author":"Pedrosa","year":"2000","journal-title":"Radiographics"}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/8\/9\/449\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:51:32Z","timestamp":1760129492000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/8\/9\/449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,15]]},"references-count":17,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["tropicalmed8090449"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed8090449","relation":{},"ISSN":["2414-6366"],"issn-type":[{"value":"2414-6366","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,15]]}}}