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The in vitro effect of Rsv on parasites was assessed via optical and electron microscopy, RT-qPCR and immunohistochemistry. In vivo efficacy was evaluated in murine models of cystic (CE) and alveolar echinococcosis (AE). The impact of infection and drug treatment on the mouse bone marrow hematopoietic stem cell (HSC) population and its differentiation into dendritic cells (BMDCs) was investigated via flow cytometry and RT-qPCR. In vitro treatment with Rsv reduced E. granulosus metacestode and protoscolex viability in a concentration-dependent manner, caused ultrastructural damage, increased autophagy gene transcription, and raised Eg-Atg8 expression while suppressing Eg-TOR. However, the intraperitoneal administration of Rsv was not only ineffective, but also promoted parasite development in mice with CE and AE. In the early infection model of AE treated with Rsv, an expansion of HSCs was observed followed by their differentiation towards BMCDs. The latter showed an anti-inflammatory phenotype and reduced LPS-stimulated activation compared to control BMDCs. We suggest that Rsv ineffectiveness could have been caused by the low intracystic concentration achieved in vivo and the drug\u2019s hormetic effect, with opposite anti-parasitic and immunomodulatory responses in different doses.<\/jats:p>","DOI":"10.3390\/tropicalmed8100460","type":"journal-article","created":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T03:49:14Z","timestamp":1695786554000},"page":"460","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Resveratrol against Echinococcus sp.: Discrepancies between In Vitro and In Vivo Responses"],"prefix":"10.3390","volume":"8","author":[{"given":"Julia A.","family":"Loos","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Producci\u00f3n, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, Nivel Cero, Mar del Plata 7600, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mar del Plata 7600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Micaela","family":"Franco","sequence":"additional","affiliation":[{"name":"Hospital Interzonal General de Agudos \u201cDr. Oscar E Alende\u201d, Mar del Plata 7600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maia","family":"Chop","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mar del Plata 7600, Argentina"},{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, Nivel 2, Mar del Plata 7600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Rodriguez Rodrigues","sequence":"additional","affiliation":[{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mar del Plata 7600, Argentina"},{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, Nivel 2, Mar del Plata 7600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Cumino","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Producci\u00f3n, Sanidad y Ambiente (IIPROSAM), Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, Nivel Cero, Mar del Plata 7600, Argentina"},{"name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Mar del Plata 7600, Argentina"},{"name":"Departamento de Qu\u00edmica, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata (UNMdP), Funes 3350, Nivel 2, Mar del Plata 7600, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e3866","DOI":"10.1136\/bmj.e3866","article-title":"Diagnosis, treatment, and management of echinococcosis","volume":"11","author":"McManus","year":"2012","journal-title":"BMJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/bs.apar.2016.09.006","article-title":"The Echinococcoses: Diagnosis, Clinical Management and Burden of Disease","volume":"96","author":"Kern","year":"2017","journal-title":"Adv. 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