{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:37:43Z","timestamp":1760143063177,"version":"build-2065373602"},"reference-count":32,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Background: As infective endocarditis has particular characteristics compared to other infectious diseases, it is not clear if sepsis scores are reported with good accuracy in these patients. The aim of this study is to evaluate the accuracy of the qSOFA and SOFA scores to predict mortality in patients with infective endocarditis. Methods: Between January 2010 and June 2019, 867 patients with suspected left-sided endocarditis were evaluated; 517 were included with left-sided infective endocarditis defined as \u201cpossible\u201d or \u201cdefinite\u201d endocarditis, according to the Modified Duke Criteria. ROC curves were constructed to assess the accuracy of qSOFA and SOFA sepsis scores for the prediction of in-hospital mortality. Results: The median age was 57 years, 65% were male, 435 (84%) had pre-existing heart valve disease, and the overall mortality was 28%. The most frequent etiologies were Streptococcus spp. (36%), Enterococcus spp. (10%), and Staphylococcus aureus (9%). The sepsis scores from the ROC curves used to predict in-hospital mortality were qSOFA 0.601 (CI95% 0.522\u20130.681) and SOFA score 0.679 (CI95% 0.602\u20130.756). A sub-group analysis in patients with and without pre-existing valve disease for SOFA \u2265 2 showed ROC curves of 0.627 (CI95% 0.563\u20130.690) and 0.775 (CI95% 0.594\u20130.956), respectively. Conclusions: qSOFA and SOFA scores were associated with increased in-hospital mortality in patients with infective endocarditis. However, as accuracy was relatively lower compared to other sites of bacterial infections, we believe that this score may have lower accuracy when predicting the prognosis of patients with IE, because, in this disease, the patient\u2019s death may be more frequently linked to valvular and cardiac dysfunction, as well as embolic events, and less frequently directly associated with sepsis.<\/jats:p>","DOI":"10.3390\/tropicalmed9010023","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T08:12:37Z","timestamp":1705392757000},"page":"23","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Predictive Value of Sepsis Scores for In-Hospital Mortality in Patients with Left-Sided Infective Endocarditis"],"prefix":"10.3390","volume":"9","author":[{"given":"Bianca Leal de","family":"Almeida","sequence":"first","affiliation":[{"name":"Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-010, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania Mara Varejao","family":"Strabelli","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor) do Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcio Sommer","family":"Bittencourt","sequence":"additional","affiliation":[{"name":"Center for Clinical and Epidemiological Research, University Hospital, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-010, SP, Brazil"},{"name":"Hospital Israelita Albert Einstein, S\u00e3o Paulo 05653-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00edtor Falc\u00e3o de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-010, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danielle Menosi","family":"Gualandro","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor) do Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6904-3039","authenticated-orcid":false,"given":"Alfredo Jose","family":"Mansur","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor) do Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Tarasouchi","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor) do Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6116-3765","authenticated-orcid":false,"given":"Lucas","family":"Pocebon","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-010, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena","family":"Paix\u00e3o","sequence":"additional","affiliation":[{"name":"Instituto do Coracao (InCor) do Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3183-234X","authenticated-orcid":false,"given":"Flora","family":"Goldemberg","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-010, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1149-4598","authenticated-orcid":false,"given":"Reinaldo","family":"Salom\u00e3o","sequence":"additional","affiliation":[{"name":"Escola Paulista de Medicina, Universidade Federal de S\u00e3o Paulo, S\u00e3o Paulo 04023-900, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rinaldo Focaccia","family":"Siciliano","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, University of S\u00e3o Paulo Medical School, S\u00e3o Paulo 05403-010, SP, Brazil"},{"name":"Instituto do Coracao (InCor) do Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05403-000, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/S0140-6736(15)00067-7","article-title":"Infective endocarditis","volume":"387","author":"Cahill","year":"2016","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"16059","DOI":"10.1038\/nrdp.2016.59","article-title":"Infective endocarditis","volume":"2","author":"Holland","year":"2016","journal-title":"Nat. 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Open"}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/9\/1\/23\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T13:47:55Z","timestamp":1760104075000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/9\/1\/23"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,16]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1]]}},"alternative-id":["tropicalmed9010023"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed9010023","relation":{},"ISSN":["2414-6366"],"issn-type":[{"type":"electronic","value":"2414-6366"}],"subject":[],"published":{"date-parts":[[2024,1,16]]}}}