{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T14:24:22Z","timestamp":1762957462886,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ricerca Corrente of the Italian Ministry of Health"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Neurocysticercosis (NCC) is caused by the larval stage of Taenia solium. This parasitic disease is endemic in many areas of the world and is emerging in Europe. NCC can affect different brain regions, but simultaneous involvement of the parenchymal, subarachnoid, and ventricular regions is rare. We report the case of a 39-year-old woman from Honduras, resident in Rome for 10 years, who presented to the Emergency Department complaining of headaches, transient hemianopsia, and bilateral papilledema. MRI showed a concomitant parenchymal, subarachnoid, and ventricular involvement in the brain. T. solium IgG antibodies were detected in the blood. The etiological diagnosis of NCC was obtained by identifying T. solium in cerebrospinal fluid using Next Generation Sequencing. Endoscopic neurosurgery with the placement of a ventricular shunt and medical long-term anti-parasitic treatment with a cumulative number of 463 days of albendazole and 80 days of praziquantel were performed. A successful 4-year follow-up is reported. NCC is one of the most common parasitic infections of the human CNS, but it is still a neglected tropical disease and is considered to be an emerging disease in Europe. Its diagnosis and clinical management remain a challenge, especially for European clinicians.<\/jats:p>","DOI":"10.3390\/tropicalmed9080187","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T04:26:57Z","timestamp":1724300817000},"page":"187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Concomitant Parenchymal, Subarachnoid, and Ventricular Neurocysticercosis in Rome, Italy: A Case Report with a 4-Year Follow-Up"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2481-6621","authenticated-orcid":false,"given":"Maria Letizia","family":"Giancola","sequence":"first","affiliation":[{"name":"Clinical Department, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5569-4121","authenticated-orcid":false,"given":"Shalom","family":"Haggiag","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6235-3934","authenticated-orcid":false,"given":"Angela","family":"Corpolongo","sequence":"additional","affiliation":[{"name":"Clinical Department, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Stasolla","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Mariano","sequence":"additional","affiliation":[{"name":"Clinical Department, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agazio","family":"Menniti","sequence":"additional","affiliation":[{"name":"Neurosurgery Unit, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7275-7358","authenticated-orcid":false,"given":"Paolo","family":"Campioni","sequence":"additional","affiliation":[{"name":"Radiology Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3882-3996","authenticated-orcid":false,"given":"Barbara","family":"Bartolini","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Biological Bank, National Institute of Infectious Diseases \u201cL. Spallanzani\u201d, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Galizia","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Vulcano","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Biological Bank, National Institute of Infectious Diseases \u201cL. Spallanzani\u201d, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2198-1947","authenticated-orcid":false,"given":"Carla","family":"Fontana","sequence":"additional","affiliation":[{"name":"Laboratory of Microbiology and Biological Bank, National Institute of Infectious Diseases \u201cL. Spallanzani\u201d, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00149 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Gasperini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Azienda Ospedaliera San Camillo Forlanini, 00152 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise","family":"O\u2019Connell","sequence":"additional","affiliation":[{"name":"Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Building 4, Bethesda, MD 20892, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hector H.","family":"Garcia","sequence":"additional","affiliation":[{"name":"Center for Global Health, Universidad Peruana Cayetano Heredia, and Cysticercosis Unit, Instituto Nacional de Ciencias Neurologicas, Av. 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Available online: https:\/\/www.paho.org\/en\/topics\/taenia-solium-taeniasiscysticercosis."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Ndimubanzi, P.C., Carabin, H., Budke, C.M., Nguyen, H., Qian, Y.J., Rainwater, E., Dickey, M., Reynolds, S., and Stoner, J.A. (2010). A systematic review of the frequency of neurocyticercosis with a focus on people with epilepsy. PLoS Negl. Trop. Dis., 4.","DOI":"10.1371\/journal.pntd.0000870"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Debacq, G., Moyano, L.M., Garcia, H.H., Boumediene, F., Marin, B., Ngoungou, E.B., and Preux, P.-M. (2017). Systematic review and meta-analysis estimating association of cysticercosis and neurocysticercosis with epilepsy. PLoS Negl. Trop. Dis., 11.","DOI":"10.1371\/journal.pntd.0005153"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"969","DOI":"10.3201\/eid2106.141324","article-title":"Hospitalization frequency and charges for neurocysticercosis, United States, 2003\u20132012","volume":"21","author":"Flecker","year":"2015","journal-title":"Emerg. Infect. Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13071-017-2280-8","article-title":"Epidemiology of taeniosis\/cysticercosis in Europe, a systematic review: Western Europe","volume":"10","author":"Devleesschauwer","year":"2017","journal-title":"Parasit. Vectors"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"taac102","DOI":"10.1093\/jtm\/taac102","article-title":"Clinical characteristics and characteristics and management of neurocysticercosis patients: A retrospective assessment of case reports from Europe","volume":"30","author":"Stelzle","year":"2023","journal-title":"J. Travel Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1007\/PL00006501","article-title":"Contributions to the phylogeny of the Cyclophyllidea (Cestoda) inferred from mitochondrial 12S rDNA","volume":"48","author":"Lucius","year":"1999","journal-title":"J. Mol. Evol."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Djikeng, A., Halpin, R., Kuzmickas, R., Depasse, J., Feldblyum, J., Sengamalay, N., Afonso, C., Zhang, X., Anderson, N.G., and Ghedin, E. (2008). Viral genome sequencing by random priming methods. BMC Genom., 9.","DOI":"10.1186\/1471-2164-9-5"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/cid\/ciz541","article-title":"A Novel, Highly Sensitive Quantitative Polymerase Chain Reaction Assay for the Diagnosis of Subarachnoid and Ventricular Neurocysticercosis and for Assessing Responses to Treatment","volume":"70","author":"Harrison","year":"2020","journal-title":"Clin. Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.4269\/ajtmh.18-0085","article-title":"Intraventricular Neurocysticercosis: Experience and Long-Term Outcome from a Tertiary Referral Center in the United States","volume":"98","author":"Nash","year":"2018","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"78","DOI":"10.4269\/ajtmh.19-0436","article-title":"Natural History of Treated Subarachnoid Neurocysticercosis","volume":"102","author":"Nash","year":"2020","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Hamamoto Filho, P.T., Norcia, L.F., Fleury, A., and Zanini, M.A. (2024). Current Role of Surgery in the Treatment of Neurocysticercosis. Pathogens, 13.","DOI":"10.3390\/pathogens13030218"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/tmi.13964","article-title":"Neurocysticercosis: The Duration of Its Preclinical Phase Relies on the Parasite Location","volume":"29","author":"Fleury","year":"2024","journal-title":"Trop. Med. Int. Health"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101683","DOI":"10.1016\/j.tmaid.2020.101683","article-title":"REDIVI Study Group. Imported cysticercosis in Spain: A retrospective case series from the +REDIVI Collaborative Network","volume":"37","author":"Herrador","year":"2020","journal-title":"Travel Med. Infect. Dis."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4338","DOI":"10.1128\/JCM.05839-11","article-title":"Confirmation and follow-up of neurocysticercosis by real-time PCR in cerebrospinal fluid samples of patients living in France","volume":"49","author":"Yera","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"ref_16","first-page":"471","article-title":"Clin Next-generation sequencing of cerebrospinal fluid for the diagnosis of neurocysticercosis","volume":"9","author":"Fei","year":"2020","journal-title":"Neurol. Neurosurg."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Fleury, A., Garcia, E., Hern\u00e1ndez, M., Carrillo, R., Govezensky, T., Fragoso, G., Sciutto, E., Harrison, L.J., and Parkhouse, R.M. (2013). Neurocysticercosis: HP10 antigen detection is useful for the follow-up of the severe patients. PLoS Negl. Trop. Dis., 7.","DOI":"10.1371\/journal.pntd.0002096"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.actatropica.2015.08.017","article-title":"Relevance of 3D Magnetic Resonance Imaging Sequences in Diagnosing Basal Subarachnoid Neurocysticercosis","volume":"152","author":"Arroyo","year":"2015","journal-title":"Acta. Trop."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"f6604","DOI":"10.1136\/bmj.f6604","article-title":"Consider tuberculoma and cysticercosis in the differential diagnosis of brain tumour in tropical countries","volume":"347","author":"Gothi","year":"2013","journal-title":"BMJ"},{"key":"ref_20","first-page":"945","article-title":"Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH)","volume":"98","author":"White","year":"2018","journal-title":"Clin. Infect. Dis."}],"container-title":["Tropical Medicine and Infectious Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2414-6366\/9\/8\/187\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:40:03Z","timestamp":1760110803000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2414-6366\/9\/8\/187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,21]]},"references-count":20,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8]]}},"alternative-id":["tropicalmed9080187"],"URL":"https:\/\/doi.org\/10.3390\/tropicalmed9080187","relation":{},"ISSN":["2414-6366"],"issn-type":[{"type":"electronic","value":"2414-6366"}],"subject":[],"published":{"date-parts":[[2024,8,21]]}}}