{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:25:01Z","timestamp":1760145901003,"version":"build-2065373602"},"reference-count":51,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T00:00:00Z","timestamp":1726704000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006162","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco (FACEPE)","doi-asserted-by":"publisher","award":["IBPG-2281-2.10\/22","001","310426\/2022-7"],"award-info":[{"award-number":["IBPG-2281-2.10\/22","001","310426\/2022-7"]}],"id":[{"id":"10.13039\/501100006162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior\u2014Brasil (CAPES)","doi-asserted-by":"publisher","award":["IBPG-2281-2.10\/22","001","310426\/2022-7"],"award-info":[{"award-number":["IBPG-2281-2.10\/22","001","310426\/2022-7"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Council for Scientific and Technological Development (CNPq)","award":["IBPG-2281-2.10\/22","001","310426\/2022-7"],"award-info":[{"award-number":["IBPG-2281-2.10\/22","001","310426\/2022-7"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Visceral leishmaniasis (VL) is a neglected tropical disease that is potentially fatal when untreated. Current diagnostic methods have limitations that contribute to ongoing transmission and poor prognosis. Thus, new tests are needed to provide quick, accurate diagnoses and evaluate clinical progression and treatment efficacy. The monokine induced by interferon-gamma (MIG) and interferon-gamma-inducible protein 10 (IP-10) has been associated with the host susceptibility to VL with potential diagnostic and prognostic purposes. We performed a systematic review using four search databases (Scopus, PubMed, Web of Science, and MEDLINE) to identify studies assessing MIG and IP-10 as potential biomarkers in patients with VL across various clinical conditions. A total of 13 studies were potentially eligible and included in this review. The articles, in general, reveal that the chemokines MIG and IP-10 are elevated in response to infection by Leishmania spp., acting on the host\u2019s resistance to the development of the disease. They are associated with asymptomatic conditions and after VL treatment, and this relationship can be observed in both immunocompetent and immunocompromised individuals. Consequently, these chemokines hold relevance in the diagnoses and appropriate management of individuals with VL.<\/jats:p>","DOI":"10.3390\/tropicalmed9090219","type":"journal-article","created":{"date-parts":[[2024,9,19]],"date-time":"2024-09-19T04:59:54Z","timestamp":1726721994000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Chemokines MIG and IP-10 as Immunological Biomarkers of Human Visceral Leishmaniasis: A Systematic Review"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9999-7036","authenticated-orcid":false,"given":"Bruna Eduarda Freitas","family":"Monteiro","sequence":"first","affiliation":[{"name":"Graduate Program in Health Biosciences and Biotechnology, Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (Fiocruz), Recife 50670-420, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elis Dion\u00edsio","family":"da Silva","sequence":"additional","affiliation":[{"name":"Health and Biotechnology Institute, Federal University of Amazonas, Coari 69460-000, AM, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter Lins","family":"Barbosa J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (Fiocruz), Recife 50670-420, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda Virginia Batista","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (Fiocruz), Recife 50670-420, PE, Brazil"},{"name":"Graduate Program in Health Sciences, University of Pernambuco, Recife 50100-130, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta dos Santos","family":"Souza","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (Fiocruz), Recife 50670-420, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Karollyne dos Santos","family":"Paiva","sequence":"additional","affiliation":[{"name":"Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (Fiocruz), Recife 50670-420, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8734-3468","authenticated-orcid":false,"given":"Pablo Cantalice Santos","family":"Farias","sequence":"additional","affiliation":[{"name":"Department of Genetics, Federal University of Pernambuco, Recife 50670-420, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1907-315X","authenticated-orcid":false,"given":"Diego Lins","family":"Guedes","sequence":"additional","affiliation":[{"name":"Faculty of Medical Sciences, University of Pernambuco, Recife 50100-130, PE, Brazil"},{"name":"Life Sciences Center, Academic Center of Agreste, Federal University of Pernambuco, Caruaru 55014-900, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7434-3223","authenticated-orcid":false,"given":"Gilberto Silva Nunes","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Department of Nursing & Healthcare, Technological University of the Shannon: Midlands Midwest, N37 HD68 Athlone, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zulma Maria","family":"de Medeiros","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Biosciences and Biotechnology, Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (Fiocruz), Recife 50670-420, PE, Brazil"},{"name":"Department of Parasitology, Aggeu Magalh\u00e3es Institute, Oswaldo Cruz Foundation (Fiocruz), Recife 50670-420, PE, Brazil"},{"name":"Institute of Biological Sciences, University of Pernambuco, Recife 50100-130, PE, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,9,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.apjtm.2016.06.021","article-title":"Worldwide risk factors in Leishmaniasis","volume":"9","author":"Oryan","year":"2016","journal-title":"Asian Pac. 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