{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T02:12:51Z","timestamp":1772244771651,"version":"3.50.1"},"reference-count":35,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T00:00:00Z","timestamp":1732838400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Brazilian Hospital Services Company (EBSERH)","award":["06\/2024"],"award-info":[{"award-number":["06\/2024"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TropicalMed"],"abstract":"<jats:p>Background: Studies of infective endocarditis (IE) are generally limited to institutions, underlining the need for more comprehensive epidemiological research. Objective: The aim of this study was to determine the mortality profile of IE-related deaths and related causes in Brazil at the national level and across regions. Method: We conducted a population-based study using data from the country\u2019s mortality information system for the period 2000 to 2019. We identified IE-related deaths and related causes based on the ICD-10 codes. Cluster analysis was performed to determine the relationship between the variables. Results: There were 52,055 IE-related deaths during the study period. Deaths occurred predominantly among men and people aged between 60 and 79 years. The Southeast accounted for the largest proportion of deaths. The most frequent ICD-10 chapter mentioned in relation to IE-related deaths was diseases of the circulatory system. We identified three distinctive profiles: 1\u2014an age of 80 years and over and women, where the most frequent chapters were endocrine, circulatory and metabolic diseases and the South and Southeast accounted for the largest proportion of deaths; 2\u2014an age between 30 and 79 years and men, where the most frequent chapters were infectious and genitourinary diseases and the South and Southeast accounted for the largest proportion of deaths; and 3\u2014an age between 0 and 29 years without any difference between sexes, where the most frequent chapter was diseases of the respiratory system and the North, Northeast and Midwest accounted for the largest proportion of deaths. Conclusions: The findings of the cluster analysis revealed distinctive IE-related mortality profiles, indicating regional differences.<\/jats:p>","DOI":"10.3390\/tropicalmed9120291","type":"journal-article","created":{"date-parts":[[2024,11,29]],"date-time":"2024-11-29T05:02:22Z","timestamp":1732856542000},"page":"291","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Mortality Profile of Deaths Related to Infective Endocarditis in Brazil and Regions: A Population-Based Analysis of Death Records"],"prefix":"10.3390","volume":"9","author":[{"given":"Jo\u00e3o Vitor Fazzio de Andrade","family":"Cordeiro","sequence":"first","affiliation":[{"name":"School of Medicine and Surgery, Federal University of the State of Rio de Janeiro, Rua Silva Ramos, 32, Tijuca, Rio de Janeiro 20270-330, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0613-5582","authenticated-orcid":false,"given":"Let\u00edcia Martins","family":"Raposo","sequence":"additional","affiliation":[{"name":"Department of Quantitative Methods, School of Mathematics, Federal University of the State of Rio de Janeiro, Av. Pasteur, 296\u2014Urca, Rio de Janeiro 22290-240, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Henrique","family":"Godoy","sequence":"additional","affiliation":[{"name":"Department of Specialized Medicine\u2014Cardiology Discipline, School of Medicine and Surgery, Federal University of the State of Rio de Janeiro, Rua Silva Ramos, 32, Tijuca, Rio de Janeiro 20270-330, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,11,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1093\/eurheartj\/ehad193","article-title":"2023 ESC Guidelines for the Management of Endocarditis: Developed by the Task Force on the Management of Endocarditis of the European Society of Cardiology (ESC) Endorsed by the European Association for Cardio-Thoracic Surgery (EACTS) and the European Association of Nuclear Medicine (EANM)","volume":"44","author":"Delgado","year":"2023","journal-title":"Eur. 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