{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T19:12:38Z","timestamp":1760209958968,"version":"build-2065373602"},"reference-count":73,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T00:00:00Z","timestamp":1513987200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Viruses"],"abstract":"<jats:p>Since the official declaration of smallpox eradication in 1980, the general population vaccination has ceased worldwide. Therefore, people under 40 year old are generally not vaccinated against smallpox and have no cross protection against orthopoxvirus infections. This na\u00efve population may be exposed to natural or intentional orthopoxvirus emergences. The virology unit of the Institut de Recherche Biom\u00e9dicale des Arm\u00e9es (France) has developed research programs on orthopoxviruses since 2000. Its missions were conceived to improve the diagnosis capabilities, to foster vaccine development, and to develop antivirals targeting specific viral proteins. The role of the virology unit was asserted in 2012 when the responsibility of the National Reference Center for the Orthopoxviruses was given to the unit. This article presents the evolution of the unit activity since 2000, and the past and current research focusing on orthopoxviruses.<\/jats:p>","DOI":"10.3390\/v10010003","type":"journal-article","created":{"date-parts":[[2017,12,26]],"date-time":"2017-12-26T03:06:38Z","timestamp":1514257598000},"page":"3","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The French Armed Forces Virology Unit: A Chronological Record of Ongoing Research on Orthopoxvirus"],"prefix":"10.3390","volume":"10","author":[{"given":"D\u00e9borah","family":"Delaune","sequence":"first","affiliation":[{"name":"Unit\u00e9 de virologie, Centre National de R\u00e9f\u00e9rence-Laboratoire Expert Orthopoxvirus, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Iseni","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de virologie, Centre National de R\u00e9f\u00e9rence-Laboratoire Expert Orthopoxvirus, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Ferrier-Rembert","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de virologie, Centre National de R\u00e9f\u00e9rence-Laboratoire Expert Orthopoxvirus, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christophe","family":"Peyrefitte","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de virologie, Centre National de R\u00e9f\u00e9rence-Laboratoire Expert Orthopoxvirus, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Ferraris","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de virologie, Centre National de R\u00e9f\u00e9rence-Laboratoire Expert Orthopoxvirus, Institut de Recherche Biom\u00e9dicale des Arm\u00e9es, 91220 Br\u00e9tigny-sur-Orge, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2017,12,23]]},"reference":[{"key":"ref_1","unstructured":"World Health Assembly (1980). 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